Erdmann, Kai, Dr

Dr Kai Erdmann

School of Biosciences

Senior Lecturer in Molecular Cell Biology

Director of Postgraduate Research

K.Erdmann@sheffield.ac.uk
+44 114 222 4698

Profile

2012-present: Senior Lecturer, School of Biosciences, 91ֱ��
2006-2012: Group leader, Ruhr-University Bochum, Germany
2005-2006: Research Associate, Yale University School of Medicine, USA
2003-2005: Feodor Lynen Fellow (Alexander von Humboldt foundation), Yale University School of Medicine, USA
1998-2003: Junior group leader, Ruhr-University Bochum, Germany
1996-1998: Postdoctoral work, Ruhr-University Bochum, Germany
1993-1996: PhD, Ruhr-University Bochum, Germany

Research interests

Molecular and Cellular Mechanobiology: Mechanisms of Mechanotransduction

Mechanical cues like extracellular matrix stiffness, fluid flow shear stress or spatial confinement play an important role in development, cell and tissue homeostasis as well as in disease initiation or progression (e.g., cancer or fibrosis). Our group is interested in how such mechanical signals are translated into cellular biochemical changes (a process called mechanotransduction) and how these changes contribute to regulate key cellular behaviour like cell proliferation and migration. Importantly, we also investigate the role of mechanotransduction in disease progression with a special focus on its role in fibrosis and cancer. We have used the well-established mechanotransducer YAP (Figure 1) as a model to develop molecular screens to identify novel proteins with a role in mechanotransduction.

Kai Erdmann - Research Image 1 — Figure 1: It is well established that the subcellular localisation of the transcription regulator YAP is controlled by ECM stiffness (A) and spatial confinement/cell spreading (B) (first reported by Dupont et al. Nature 2011).

Note: We are aiming to identify proteins that are controlled in a similar manner and investigate their role in mechanotransduction.

Membrane trafficking: Regulation of receptor cell surface expression

Cell surface expression levels of receptors are controlled by a tight balance of receptor endocytosis and recycling. We are investigating underpinning membrane trafficking mechanisms that regulate receptor cell surface expression. In particular we are interested in the cell surface regulation of the apoptosis receptor Fas/CD95 and have recently identified a novel crosstalk between regulation of Fas/CD95 membrane trafficking and apoptotic signalling (Figure 2). More recently we have started to investigate the effect of mechanical cues like ECM stiffness on the regulation of membrane trafficking as part of the cellular mechanoresponse.

BMS - Kai Ermann - Research Image 02 — Figure 2: Model of impaired Fas endolysosomal sorting, which leads to a positive feedback loop of apoptotic signalling (Sharma et al. Nature Commun. 2019).

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Sharma S, Carmona A, Skowronek A, Yu F, Collins MO, Naik S, Murzeau CM, Tseng P-L & Erdmann KS (2019) . Nature Communications, 10(1).
Yu F, Sharma S, Skowronek A & Erdmann KS (2016) . Scientific Reports, 6.
Hagemann N, Ackermann N, Christmann J, Brier S, Yu F & Erdmann KS (2012) . Oncogene.
Hou X, Hagemann N, Schoebel S, Blankenfeldt W, Goody RS, Erdmann KS & Itzen A (2011) . EMBO Journal, 30(8), 1659-1670.
Stenzel N, Fetzer CP, Heumann R & Erdmann KS (2009) . Journal of Cell Science, 122(18), 3374-3384.
Erdmann KS, Mao Y, McCrea HJ, Zoncu R, Lee S, Paradise S, Modregger J, Biemesderfer D, Toomre D & De Camilli P (2007) . Dev Cell, 13(3), 377-390.

All publications

Journal articles

Naik S, Wood AR, Ongenaert M, Saidiyan P, Elstak ED, Lanz HL, Stallen J, Janssen R, Smythe E & Erdmann KS (2021) . International Journal of Molecular Sciences, 22(10).
Beaurivage C, Kanapeckaite A, Loomans C, Erdmann KS, Stallen J & Janssen RAJ (2020) . Scientific Reports, 10(1).
Naumovska E, Aalderink G, Wong Valencia C, Kosim K, Nicolas A, Brown S, Vulto P, Erdmann KS & Kurek D (2020) . International Journal of Molecular Sciences, 21(14).
Tait CM, Chinnaiya K, Manning E, Murtaza M, Ashton J-P, Furley N, Hill CJ, Alves CH, Wijnholds J, Erdmann KS , Furley A et al (2020) . PLOS Biology, 18(3).
Dicks M, Kock G, Kohl B, Zhong X, Pütz S, Heumann R, Erdmann KS & Stoll R (2019) . BMC Molecular and Cell Biology, 20(1).
Sharma S, Carmona A, Skowronek A, Yu F, Collins MO, Naik S, Murzeau CM, Tseng P-L & Erdmann KS (2019) . Nature Communications, 10(1).
Beaurivage C, Naumovska E, Chang Y, Elstak E, Nicolas A, Wouters H, van Moolenbroek G, Lanz H, Trietsch S, Joore J , Vulto P et al (2019) . International Journal of Molecular Sciences, 20(22).
Erdmann KS, Kock G, Dicks M, Yip KT, Kohl B, Puetz S, Heumann R & Stoll R (2018) . Journal of Molecular Biology.
Yu F, Sharma S, Skowronek A & Erdmann KS (2016) . Scientific Reports, 6.
Chen J, Balakrishnan-Renuka A, Hagemann N, Theiss C, Chankiewitz V, Chen J, Pu Q, Erdmann KS & Brand-Saberi B (2016) . Histochemistry and Cell Biology, 145(1), 5-16.
Sharma S, Skowronek A & Erdmann KS (2015) . Biological Chemistry, 396(12).
Lipinski S, Grabe N, Jacobs G, Billmann-Born S, Till A, Has ler R, Aden K, Paulsen M, Arlt A, Kraemer L , Hagemann N et al (2012) . Proceedings of the National Academy of Sciences of the United States of America, 109(52), 21426-21431.
Hagemann N, Ackermann N, Christmann J, Brier S, Yu F & Erdmann KS (2012) . Oncogene.
Hagemann N, Hou X, Goody RS, Itzen A & Erdmann KS (2012) . Small GTPases, 3(2), 107-110.
Hou X, Hagemann N, Schoebel S, Blankenfeldt W, Goody RS, Erdmann KS & Itzen A (2011) . EMBO Journal, 30(8), 1659-1670.
Kock G, Dicks M, Heumann R, Erdmann KS & Stoll R (2010) . Biomol NMR Assign, 4(2), 199-202.
Stenzel N, Fetzer CP, Heumann R & Erdmann KS (2009) . Journal of Cell Science, 122(18), 3374-3384.
Mao Y, Balkin DM, Zoncu R, Erdmann KS, Tomasini L, Hu F, Jin MM, Hodsdon ME & De Camilli P (2009) . EMBO J, 28(13), 1831-1842.
Oknianska AR, Welters HJ, Erdmann KS, Ryffel GU & Morgan NG (2008) The protein tyrosine phosphatase, PTP-BL, regulates pancreatic beta cell proliferation by interacting with components of the Writ signalling pathway. DIABETOLOGIA, 51, S191-S191.
Welters HJ, Oknianska A, Erdmann KS, Ryffel GU & Morgan NG (2008) . Journal of Endocrinology, 197(3), 543-552.
Fetzer CP, Sauvageau J, Kock G, Berghaus C, Bangert J-A, Dicks M, Heumann R, Erdmann KS & Stoll R (2007) . Biomol NMR Assign, 1(2), 151-153.
Erdmann KS, Mao Y, McCrea HJ, Zoncu R, Lee S, Paradise S, Modregger J, Biemesderfer D, Toomre D & De Camilli P (2007) . Dev Cell, 13(3), 377-390.
Itoh T, Erdmann KS, Roux A, Habermann B, Werner H & De Camilli P (2005) . Dev Cell, 9(6), 791-804.
Hartmann M, Brigadski T, Erdmann KS, Holtmann B, Sendtner M, Narz F & Leßmann V (2004) . Journal of Cell Science, 117(24), 5803-5814.
Erdmann KS (2003) . European Journal of Biochemistry, 270(24), 4789-4798.
Kachel N, Erdmann KS, Kremer W, Wolff P, Gronwald W, Heumann R & Kalbitzer HR (2003) . Journal of Molecular Biology, 334(1), 143-155.
Herrmann L, Dittmar T & Erdmann KS (2003) . Mol Biol Cell, 14(1), 230-240.
Palmer A, Zimmer M, Erdmann KS, Eulenburg V, Porthin A, Heumann R, Deutsch U & Klein R (2002) . Molecular Cell, 9(4), 725-737.
Klau M, Hartmann M, Erdmann KS, Heumann R & Lessmann V (2001) . Journal of Neuroscience Research, 66(3), 327-336.
Gross C, Heumann R & Erdmann KS (2001) . FEBS Letters, 496(2-3), 101-104.
Schultze W, Eulenburg V, Lessmann V, Herrmann L, Dittmar T, Gundelfinger ED, Heumann R & Erdmann KS (2001) . J Neurochem, 78(3), 482-489.
Erdmann KS, Kuhlmann J, Lessmann V, Herrmann L, Eulenburg V, Müller O & Heumann R (2000) . Oncogene, 19(34), 3894-3901.
Hartmann M, Narz F, Erdmann KS, Heumann R & Lessmann V (2000) Investigating TrkB receptor targeting in cortical neurons by means of a signaling-competent TrkB-EGFP fusion protein. EUROPEAN JOURNAL OF NEUROSCIENCE, 12, 3-3.
Erdmann KS, Eulenburg V & Heumann R (2000) The ephrinB-family interacts with the proteintyrosinephosphatase PTP-BL. EUROPEAN JOURNAL OF NEUROSCIENCE, 12, 180-180.
Will GK, Soukupova M, Hong X, Erdmann KS, Kiel JA, Dodt G, Kunau WH & Erdmann R (1999) . Mol Cell Biol, 19(3), 2265-2277.
Erdmann KS, Eulenburg V, Herrmann L, Alev C & Heumann R (1999) Interaction of the ephrinB-family with the proteintyrosine phosphatase PTPL1/PTP-BL. JOURNAL OF NEUROCHEMISTRY, 73, S125-S125.
Erdmann KS, Kaiser AD, Klinz FJ, Zhong J, Krautwald S & Heumann R (1998) . Biochem Biophys Res Commun, 249(3), 891-897.
Vinh NQ, Erdmann KS & Heumann R (1994) . Gene, 149(2), 383-384.

Conference proceedings papers

Yu F, Hagemann N, Ackermann N & Erdmann KS (2014) Protein tyrosine phosphatase PTPN13 and its interaction partner SDCCAG3 are involved in the regulation of cytokinesis. FEBS JOURNAL, Vol. 281 (pp 78-78)
Skowronek A, Hagemann N & Erdmann KS (2014) FERM and PDZ domain containing protein 2 regulates epithelial cell polariZation. FEBS JOURNAL, Vol. 281 (pp 197-197)

Preprints

Tseng P-L, Sun W, Salem A, Macfarlane S, Gad AKB, Collins MO & Erdmann KS (2024) , Cold Spring Harbor Laboratory.
Tait C, Chinnaiya K, Murtaza M, Ashton J-P, Furley N, Hill CJ, Henrique Alves C, Wijnholds J, Erdmann KS, Das RM , Rashbass P et al (2019) , Cold Spring Harbor Laboratory.

Research group

Andrew Wood (arwood1@sheffield.ac.uk)
Pei Li Tseng (pltseng1@sheffield.ac.uk)
Ahmed Salem (amasalem1@sheffield.ac.uk)
Mubarak Alaklobie (msalaklobie1@sheffield.ac.uk)
Weiwei Sun (wsun22@sheffield.ac.uk)

Previous lab members:

Fangyan Yu
Shruti Sharma
Agnieszka Skowronek
Claire Murzeau
Kinga Kosim
Sindhu N Naik
Antonio Carmona-Serrano
Elena Naumovska
Claudia Beaurivage

Collaborations:

Jochen Guck Technical University, Dresden, Germany

Grants

(Deutsche Forschungsgemeinschaft)

Teaching activities

Undergraduate and postgraduate taught modules

Undergraduate

BMS110 Research Topics in Biomedicine
BMS301 Membrane Receptors
BMS376 Membrane Trafficking
Level 3 Practical and Dissertation Modules

MSc (Masters)

BMS6082 Practical Cell Biology

Professional activities and memberships

Coordinator of the Marie Curie Initial Training Network (ITN)
Visiting scientist Yale University School of Medicine (Sept/Oct. 2011)
Eurotrans-Bio (ETB) Award (2011) (consortium)
Feodor Lynen postdoctoral fellow (Alexander von Humboldt foundation) (2003-2005)

Opportunities

We advertise PhD opportunities (Funded or Self-Funded) on FindAPhD.com

For further information about these projects and how to apply at 91ֱ��, see our PhD Opportunities page.