Scientists from the University of 91直播 have discovered a compound that could be more effective in treating certain cancers than standard chemotherapy.
Chemotherapy is still the first line of defence for most cancer tumours and is often highly effective. However, many cancers are naturally resistant, or develop resistance, to commonly used first-line chemotherapy drugs like cisplatin.
Researchers from the University of 91直播鈥檚 Departments of Biomedical Science and Chemistry collaborated to identify new drug-candidates that would work against these types of treatment resistant cancers.
In the paper, published in the Journal of the American Chemical Society, scientists screened new compounds made in the lab against a "panel" of cancers that were sensitive and resistant to standard cancer therapy.
The researchers also tested the compounds with non-malignant cells to see how toxic they were to normal cells. They found two lead compounds that had low toxicity to non-malignant cells but were highly active against cancer cells sensitive or resistant to standard treatment.
Professor Jim Thomas, from the University鈥檚 Department of Chemistry, said: 鈥淢any cancer cells - about 20 per cent - become resistant to common treatments by learning to ignore the internal signals that tell them to undergo programed cell death, known as apoptosis.
鈥淲e have identified a compound that kills cancer cells that avoids the need for apoptosis, and so the usual resistance mechanism doesn't work against our compound.
鈥淭he compound is as potent as common current chemotherapeutics, but crucially retains its potency against treatment-resistant cancers. By looking at the cellular response from the cancers we found the new drug lead works by two different mechanisms simultaneously, making it much more difficult for cancers to develop resistance toward them during treatment.
鈥淲e think this compound could be particularly effective against ovarian cancer.鈥
The team used a technique called 鈥減roteomics鈥 to determine how thousands of proteins in the cells responded to exposure to the drug lead.
Professor Carl Smythe, from the University鈥檚 Department of Biomedical Science, said: 鈥淧roteomics is a remarkably powerful approach we have in 91直播 to identify how living things respond to new drug candidates. The multiple mechanisms of action of the new molecules was an unexpected and exciting result.鈥
Researchers now want to carry out further studies to find out if the compound can be used in combination with current treatments to improve their performance.
Professor Thomas added: 鈥淲e also want to discover if we can identify derivatives that further enhance the effectiveness of the drugs without being harmful to 鈥榥ormal鈥 non-malignant cells and discover against what types of cancers the compounds are most effective.鈥
