Professor Sheila Francis
BSc PhD SFHEA FRSB
Clinical Medicine, School of Medicine and Population Health
Faculty Director of One University Strategy Delivery (FDOU)
Professor of Cardiovascular Biology
+44 114 215 9501
Full contact details
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
91直播
S10 2RX
- Profile
-
For enquiries, please contact 鈥 ClinMed-Operational@sheffield.ac.uk
For One University Strategy enquiries in the Faculty of Health, please contact Isabel Andrews.
I joined the University of 91直播 in 1990 after a BBSRC CASE PhD studentship at the University of Manchester. After four years as a Postdoctoral Research Associate in Cardiac Surgery (with Angelini) and Molecular Medicine (with Duff), I held an Independent Open Competition Fellowship from the Lloyd麓s Tercentenary Foundation on the molecular and inflammatory basis of coronary artery disease.
After being appointed Lecturer in 1994, I spent a sabbatical period in the at MIT as a Fulbright Scholar. I am currently a Professor of Cardiovascular Biology at the University of 91直播.
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- Research interests
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I have a long-standing interest in the role of interleukin-1 (IL-1) and its naturally occurring antagonist, IL-1ra in modulating vascular cell function in experimental models and in human disease. Over the past 10-15 years, I have shown that IL-1 and IL-1ra are increased in diseased human arteries and in other experimental cardiovascular systems. I described the association of a genetic variant of IL-1ra with coronary artery disease and showed that this variant alters protein levels and the biology of endothelial cells.
Programme funding from the British Heart Foundation (with Professor David Crossman) allowed the use of strategies to inhibit IL-1 in several experimental models including atherosclerosis in mice. The impact of this early work alongside that of others has now been translated to man through the ILA-HEART and .
My current research areas of interest relate to the mechanisms by which IL-1 is released from vascular cells especially endothelial cells, IL-1 related molecules and their antagonists, and the role of IL-1 in complex vascular phenotypes such as inflammatory vascular plaques in the brain and the mixed models of atherosclerosis after chronic infection and also episodes of hypoglycaemia. More recently, I have become interested in the control of endothelial senescence and impacts upon age-related diseases working with colleague in HELSI.
I collaborate with colleagues in Infection, Immunity and Cardiovascular Disease, Metabolism, Psychology and Neuroscience at the University of 91直播 and with colleagues at the Universities of Manchester (Pinteaux, Allan), the University of Virginia (Owens, Abbate) and others.
Current projects
- Release of IL-1 from vascular cells especially endothelial cells.
- S.pneumoniae infection and atherosclerosis (with Bazaz and Dockrell (Edinburgh)).
- Hypoglycaemia and risk of atherosclerosis (with Iqbal and Heller).
- Interleukin-1 alpha versus interleukin-1 beta in atherosclerosis, hypertension and stroke (with Pinteaux and Allan, Manchester)).
- Macrophage phenotypes in human carotid atherosclerosis (with Kiss-Toth and Redgrave).
- Neurovascular function in atherosclerosis (with Wharton, Berwick and Howarth).
- Approaches to alter endothelial senescence and ageing (with Bellantuono).
- PKC alpha/TGF beta axis in atherosclerosis and medical calcification (with Brennan, Canfield and Borland, Manchester)
- Vascular Brain pathology (with Simpson and Wharton)
- Inflammation, atherosclerosis and molecular manipulation of the microbiome (with Jon Shaw)
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Journal of the American Heart Association, e032987.
- . Disease Models & Mechanisms, 16(7).
- . Frontiers in Cellular and Infection Microbiology, 13.
- . Alzheimer's & Dementia, 18(S6).
- . Vascular Biology, 4(1), 11-18.
- . Science Advances, 8(35).
- . Frontiers in Cardiovascular Medicine, 9.
- . eLife, 2022(11).
- . Mechanisms of Ageing and Development, 192, 111361-111361.
- . Journal of Molecular Medicine, 98(7), 923-930.
- . Science Advances, 5(10).
- . JCI Insight, 4(17).
- . Proceedings of the National Academy of Sciences, 116(26), 13067-13076.
- . Brain Behavior and Immunity, 76, 126-138.
- . Nature Medicine, 24(9), 1418-1429.
- . Journal of the American Heart Association, 7(13).
- . Pulmonary Circulation.
- . JACC - Journal of the American College of Cardiology bts, 2(4), 398-414.
- . Oncotarget, 7, 75571-75584.
- . Circulation Research, 119, 450-462.
- . Journal of Clinical Investigation, 126(7), 2495-2508.
- . Journal of Biological Chemistry, 290, 24067-24078.
- . Annals of Neurology, 75(5), 670-683.
Preprints
All publications
Journal articles
- . Journal of the American Heart Association, e032987.
- . Disease Models & Mechanisms, 16(7).
- . Frontiers in Cellular and Infection Microbiology, 13.
- . Alzheimer's & Dementia, 18(S6).
- . Vascular Biology, 4(1), 11-18.
- . Science Advances, 8(35).
- . Frontiers in Cardiovascular Medicine, 9.
- . eLife, 2022(11).
- . Optica, 8(12), 1588-1595.
- . npj Breast Cancer, 7(1).
- . Journal of Clinical Investigation, 131(11).
- . Journal of Cardiovascular Pharmacology, Publish Ahead of Print.
- . Mechanisms of Ageing and Development, 192, 111361-111361.
- . Journal of Molecular Medicine, 98(7), 923-930.
- . Scientific Reports, 10(1).
- . Scientific Reports, 10(1).
- . Nature Communications, 11(1).
- . Nature Communications, 10(1).
- . Science Advances, 5(10).
- . Open Forum Infectious Diseases, 6(Supplement_2), S207-S207.
- . JCI Insight, 4(17).
- . Proceedings of the National Academy of Sciences, 116(29), 14782-14782.
- . Proceedings of the National Academy of Sciences, 116(26), 13067-13076.
- . Basic Science.
- . Basic Science.
- . Basic Science.
- . Journal of Clinical Endocrinology and Metabolism, 104(4), 1187-1199.
- . Brain Behavior and Immunity, 76, 126-138.
- . BMC Neuroscience, 19.
- . Cardiovascular Research, 114(14), 1845-1847.
- . Cardiovascular Research, 114(suppl_2), S2-S2.
- . Nature Medicine, 24(9), 1418-1429.
- . Journal of the American Heart Association, 7(13).
- . European Journal of Preventive Cardiology, 25(9), 948-955.
- . Pulmonary Circulation, 8(1), 1-11.
- . Cardiovascular Research, 113(13), 1639-1652.
- . Pulmonary Circulation.
- . JACC - Journal of the American College of Cardiology bts, 2(4), 398-414.
- . Scientific Reports, 7.
- . Oncotarget, 7, 75571-75584.
- . Circulation Research, 119, 450-462.
- . Journal of Clinical Investigation, 126(7), 2495-2508.
- . Annals of Biomedical Engineering, 44(2), 453-465.
- . Circulation, 132(suppl_3).
- . Circulation, 132(suppl_3).
- . Journal of Biological Chemistry, 290, 24067-24078.
- . Biochemical Society Transactions, 43(5), 1069-1074.
- . Molecular & Cellular Oncology, 2(3).
- . Cell Death & Differentiation, 22(1), 131-144.
- . EuroIntervention, 10(6), 709-716.
- Neutrophil elastase enhances IL-1 beta secretion from coronary endothelium via an endolysosomal mediated mechanism, without caspase-1 activation. ANGIOGENESIS, 17(4), 941-941.
- . Atherosclerosis, 235(2), 613-618.
- . Heart, 100(Suppl 3), A88.2-A89.
- . Heart, 100 Suppl 3, A116-A117.
- . Heart, 100.
- . Annals of Neurology, 75(5), 670-683.
- . PLoS ONE, 9(3).
- . PLoS One, 9(2), e88767.
- . Cardiovasc Res, 102(3), 429-435.
- . PLoS One, 9(2), e88388.
- . Prog Mol Biol Transl Sci, 124, 1-18.
- . Heart, 100 Suppl 1, A2.
- The role of vessel wall P2Y12 in early atherogenesis is not blocked by ticagrelor or clopidogrel. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, 156-156.
- . European Heart Journal, 34(22), 1636-1643.
- . Biochim Biophys Acta, 1831(10), 1573-1578.
- . PLoS One, 8(1), e54636.
- . J Infect, 66(1), 1-17.
- . Biology (Basel), 1(1), 43-57.
- . J Exp Med, 209(11), 1919-1935.
- . Journal of the American Heart Association, 1(3).
- . Heart, 98(Suppl 3), A6.1-A6.
- . Journal of Innate Immunity, 4(3), 260-272.
- . Pulm Circ, 2(1), 21-27.
- . Heart, 97(20), e7-e7.
- . Heart, 97(20), e7-e7.
- . Arteriosclerosis Thrombosis and Vascular Biology, 31, 1988-1990.
- . J Leukoc Biol, 90(5), 855-865.
- TRAIL attenuates the development of atherosclerosis in apolipoprotein E deficient mice. Atherosclerosis.
- . Am J Pathol, 179(4), 1693-1705.
- . Brain, Behavior, and Immunity, 25(6), 1113-1122.
- . Atherosclerosis, 215(2), 348-354.
- Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain, Behavior, and Immunity.
- . PLoS Pathog, 7(1), e1001262.
- Sustained P2Y12 Receptor Inhibition is Required to Effectively Inhibit Neointima Formation in a Murine Vascular Injury Model. CIRCULATION, 122(21).
- . Arterioscler Thromb Vasc Biol, 30(12), 2385-2391.
- . Heart, 96(17), e27-e27.
- . Heart, 96(17), e18-e18.
- . J Biol Chem, 285(30), 23147-23158.
- . TRANSFUS APHER SCI, 42(1), 97-99.
- . Immunology, 128(1), 58-68.
- . Cardiovasc Res, 85, 38-44.
- . Atherosclerosis Supplements, 10(2), e463-e463.
- . Clin Exp Immunol, 156(3), 386-394.
- . Circulation, 119(1), 116-122.
- . Int Immunol, 20(12), 1543-1550.
- . FEBS Lett, 582(6), 886-890.
- . Immunol Lett, 116(2), 178-183.
- . The American Journal of Pathology, 172(1), 256-264.
- . Circulation, 116(suppl_16).
- Deletion of tumour necrosis factor-related apoptosis-inducing ligand attenuates development of atherosclerosis in ApoE null mice. EUROPEAN HEART JOURNAL, 28, 110-110.
- . Journal of Thrombosis and Haemostasis, 5.
- . J Biol Chem, 282(25), 18379-18387.
- . Br J Pharmacol, 151(1), 115-127.
- . Vascular Pharmacology, 45(3), e28-e28.
- . Immunol Lett, 104(1-2), 171-177.
- . The American Journal of Pathology, 168(4), 1396-1403.
- . Cytokine, 33(5), 274-280.
- . Cardiovasc Res, 68(3), 493-501.
- . Am Heart J, 150(3), 488-499.
- . Gene Ther, 12(14), 1154-1157.
- . Journal of Thrombosis and Haemostasis, 3(2), 287-291.
- . Journal of Thrombosis and Haemostasis, 2(11), 2053-2054.
- . The American Journal of Human Genetics, 75(3), 436-447.
- . J Immunol, 173(2), 1202-1208.
- . Heart, 90(6), 591-592.
- . Cardiovascular Pathology, 13(3), 93-93.
- . Cardiovascular Pathology, 13(3), 117-117.
- . Cardiovascular Pathology, 13(3), 95-95.
- . Cardiovascular Pathology, 13(3), 116-117.
- . Cardiovascular Pathology, 13(3), 127-127.
- . Clinical Science, 106(s50), 2P-2P.
- . Ultrasound Med Biol, 29(10), 1453-1461.
- . Lab Invest, 83(10), 1497-1508.
- . Circ Res, 92(12), 1285-1287.
- . Biochemical Society Transactions, 30(5), A130-A130.
- . Clin Sci (Lond), 103(3), 303-310.
- . Arterioscler Thromb Vasc Biol, 22(6), 927-933.
- . Cold Spring Harbor Symposia on Quantitative Biology, 67, 143-153.
- . Arterioscler Thromb Vasc Biol, 21(11), 1727-1732.
- Differential regulation of endothelial function and systemic inflammation by gene variation at the IL-1 locus during acute coronary syndromes. CIRCULATION, 104(17), 390-391.
- Polymorphism at the IL-1 locus determines the endothelial but not the systemic response in acute coronary syndromes. EUR HEART J, 22, 373-373.
- . Heart, 86(3), 336-340.
- . Cardiovasc Res, 50(1), 125-136.
- . Circulation, 103(8), 1135-1141.
- A cell kinetic analysis of human umbilical vein endothelial cells. MECH AGEING DEV, 120(1-3), 23-32.
- . Gene Ther, 7(23), 2023-2027.
- . Arteriosclerosis, Thrombosis, and Vascular Biology, 20(11), 2394-2400.
- Possible different involvement of interleukin-1 receptor antagonist gene polymorphism in coronary single vessel disease and myocardial infarction - Response. CIRCULATION, 101(18), E193-E193.
- Mammalian suppressor of sgv-1 (MSS1), a putative transcription factor and differentiation related gene, is upregulated in explant derived compared with enzyme dispersed human aortic vascular smooth muscle cells in vitro. J AM COLL CARDIOL, 35(2), 49A-49A.
- VEGF promoter polymorphisms and the risk of ischaemic heart disease. J AM COLL CARDIOL, 35(2), 306A-306A.
- Antisense oligonucleotide to c-myb induces apoptosis in vascular smooth muscle cells in vitro and in vivo. Heart, 83(SUPPL. 1).
- . Cardiovasc Res, 44(2), 436-448.
- . Cardiovascular Research, 44(1), 156-165.
- . Circulation, 99(20), 2617-2620.
- . Circulation, 99(7), 861-866.
- . Methods Mol Med, 30, 39-46.
- Interleukin-1 receptor antagonist (IL-1RA) in human diseased arteries: Association of allele 2 of IL-1RN (+2016) human gene polymorphism with reduced expression in endothelial cells. Heart, 81(SUPPL. 1).
- . Clinical Science, 95(6), 659-659.
- Transforming growth factor-beta gene polymorphisms and coronary artery disease. CLIN SCI, 95(6), 659-667.
- . Heart, 80(5), 509-516.
- . Perfusion, 13(6), 409-417.
- . Circulation, 98(16), 1657-1665.
- 1MHz ultrasound enhances transfection of porcine aortic endothelial cells in vitro and oligonucleotide uptake in an organ culture model.. AM J CARDIOL, 82(7A), 29S-29S.
- Aorto-ostial stent: Procedural, angiographic and histological evaluation in porcine coronary arteries.. AM J CARDIOL, 82(7A), 68S-68S.
- . Clinical Science, 95(3), 311-315.
- Methylenetetrahydrofolate reductase polymorphism (C-677T) and coronary artery disease. CLIN SCI, 95(3), 311-315.
- Apoptosis and cell proliferation following porcine angioplasty. J AM COLL CARDIOL, 31(2), 22A-22A.
- Nigh frequency ultrasound enhances transfection of porcine vascular smooth muscle cells in vitro. J AM COLL CARDIOL, 31(2), 25A-25A.
- . J Mol Cell Cardiol, 30(2), 215-223.
- Interleukin-1 (IL-1) gene polymorphisms: Risk of coronary arterial disease. Heart, 79(SUPPL. 1).
- The BioDivYsio(R) stent: Morphometric superiority to the Palmaz-Schatz stent in the porcine coronary model. AMERICAN JOURNAL OF CARDIOLOGY, 80, TCT95-TCT95.
- . Circ Res, 80(4), 520-531.
- Modulation of Bcl-2 and the related proteins Bak and Bax during in vitro ageing of HUVEC. Heart, 77(SUPPL. 1).
- In-stent restenosis: More metal and more symmetry required?. Heart, 77(SUPPL. 1).
- Z-VAD but not Z-DEVD inhibits serum withdrawal induced apoptosis of HUVEC in vitro. Heart, 77(SUPPL. 1).
- . Arterioscler Thromb Vasc Biol, 16(8), 1000-1006.
- Neutrophils are a source of interleukin-6 in human cardiopulmonary bypass surgery. HEART, 75(5), 100-100.
- c-fms proto-oncogene expression is increased in endothelial and smooth muscle cells following vascular grafting. HEART, 75(5), 161-161.
- Early response gene expression and vascular cell proliferation in human saphenous vein prepared for coronary bypass grafting. HEART, 75(5), 279-279.
- Apoptosis of human umbilical vein endothelial cells (HUVEC) - Role of interleukin-1 beta converting enzyme (ICE) and associated proteases. HEART, 75(5), 11-11.
- Restenosis after balloon angioplasty: Intimal hyperplasia or vessel remodelling?. HEART, 75(5), 88-88.
- UP-REGULATION OF THE EARLY RESPONSE GENES C-FOS, C-JUN AND C-MYC IN SURGICALLY PREPARED HUMAN SAPHENOUS-VEIN. CIRCULATION, 92(8), 3080-3080.
- INTRA-CORONARY DRUG-DELIVERY VIA POROUS BALLOON - LOCAL OR REGIONAL. CIRCULATION, 92(8), 3220-3220.
- . Journal of the American College of Cardiology, 25(2), 376A-377A.
- . Cardiovasc Surg, 3(2), 171-174.
- Release of platelet-derived growth factor activity from pig venous arterial grafts.. J Thorac Cardiovasc Surg, 108(3), 540-548.
- . Cardiovasc Res, 28(8), 1170-1175.
- DETECTION OF IL-1 IN HUMAN ATHEROSCLEROSIS. J CELL BIOCHEM, 285-285.
- INTERLEUKIN-10 IN HUMAN ARTERIES AND VEINS. J CELL BIOCHEM, 284-284.
- . Nucleic Acids Res, 21(12), 2944.
- . Ann Thorac Surg, 55(6), 1522-1528.
- . Biochimica et Biophysica Acta (BBA) - Biomembranes, 1147(2), 251-261.
- . International Journal of Angiology, 2(03), 105-111.
- . Cardiovasc Res, 26(12), 1189-1194.
- SERUM-FREE ORGAN-CULTURE OF VASCULAR TISSUES. IN VITRO CELL DEV-AN, 28A(11-12), 693-694.
- ANOTHER CAUTIONARY NOTE ON THE USE OF PCNA. J PATHOL, 166(4), 418-418.
- HEPARIN AND NEOINTIMAL THICKENING IN AN ORGAN-CULTURE OF HUMAN SAPHENOUS-VEIN. ATHEROSCLEROSIS, 93(1-2), 155-156.
- . Colloids and Surfaces, 62(1-2), 177-184.
- . The Journal of Pathology, 166(4), 417-420.
- . Biochimica et Biophysica Acta (BBA) - Biomembranes, 1062(2), 117-122.
- . Biochimica et Biophysica Acta (BBA) - Biomembranes, 987(2), 212-216.
- . Biochemical Society Transactions, 17(3), 558-559.
- . Biochimica et Biophysica Acta (BBA) - Biomembranes, 978(1), 17-24.
- . Scientific Reports, 14(1).
- . International Journal of Molecular Sciences, 21(12), 4538-4538.
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- . PLoS ONE, 9(5), e97392-e97392.
- . PLoS ONE, 4(4), e5073-e5073.
- . International Journal of Angiology, 2(03), 105-111.
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- Interleukin-1尾 promotes an atheroprotective distribution of smooth muscle cells and macrophages in late stage murine atherosclerotic lesions. Nature Medicine.
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Chapters
Conference proceedings papers
- . 13.01 - Pulmonary hypertension
- . A14. THIS IS GETTING COMPLICATED: EPIGENETICS, -OMICS, AND CELL SIGNALING IN PULMONARY HYPERTENSION
- . Heart, Vol. 107(Suppl 1) (pp a172-a173)
- . Heart, Vol. 107(Suppl 1) (pp a156-a156)
- The effect of systemic atherosclerosis on the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 21-21)
- . A107. BYSTANDERS NO MORE: INFLAMMATION, IMMUNITY AND THROMBOSIS IN PULMONARY VASCULAR AND LUNG DISEASE
- Myeloid TRIB1 Controls Metabolic Tissue Resident Macrophage Phenotype Associated with Immuno-Metabolic Diseases. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 271-271)
- The effect of systemic atherosclerosis in the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 45 (pp 31-31)
- Acute hypoglycaemia results in increased activation of responses to an inflammatory challenge induced 48 hours later in human subjects. DIABETOLOGIA, Vol. 61 (pp S446-S446)
- . Cardiovascular Research, Vol. 114(suppl_2) (pp S5-S6)
- . Cardiovascular Research, Vol. 114(suppl_2) (pp S4-S4)
- CONSEQUENCES OF TRIB3 DEFICIENCY ON EXPERIMENTAL ATHEROSCLEROSIS AND MACROPHAGE PHENOTYPE. CARDIOVASCULAR RESEARCH, Vol. 114 (pp S2-S2)
- . Heart, Vol. 104(Suppl 6) (pp A102-A103), 4 June 2018 - 6 June 2018.
- . Basic Science
- . Basic Science
- . Basic Science
- . Atherosclerosis Supplements, Vol. 32 (pp 11-11)
- Expression of SMURF1 is Increased in Patients With Pulmonary Arterial Hypertension and SiRNA Inhibition of SMURF1 Reduces Pulmonary Artery Smooth Muscle Cell Proliferation. CIRCULATION, Vol. 138
- Development of a Novel Human Anti-OPG Antibody That Attenuates Experimental Pulmonary Arterial Hypertension. CIRCULATION, Vol. 136
- Hypoglycaemia increases platelet reactivity and promotes formation of proatherogenic platelet-leucocyte aggregates. DIABETOLOGIA, Vol. 60 (pp S532-S532)
- . Heart, Vol. 103(Suppl 5) (pp A113.2-A113)
- . Heart, Vol. 103(Suppl 5) (pp A139.2-A140)
- . Heart, Vol. 102(Suppl 6) (pp A123.2-A124), 6 June 2016 - 8 June 2016.
- . Heart, Vol. 102(Suppl 6) (pp A140.1-A140), 6 June 2016 - 8 June 2016.
- . Heart, Vol. 102(Suppl 6) (pp A116.2-A117)
- . Heart, Vol. 102(Suppl 6) (pp A147-A147)
- . Heart, Vol. 102(Suppl 6) (pp A114.2-A114), 6 June 2016 - 8 August 2016.
- . Thorax, Vol. 70(Suppl 3) (pp A5.3-A6)
- . Thorax, Vol. 70(Suppl 3) (pp A3.1-A3)
- . Atherosclerosis, Vol. 241(1) (pp e34-e34)
- . Heart, Vol. 101(Suppl 4) (pp A107.2-A107)
- . Heart, Vol. 101(Suppl 4) (pp A118.2-A119)
- . Heart, Vol. 101(Suppl 4) (pp A104.2-A105)
- . Heart, Vol. 101(Suppl 4) (pp A117.2-A118)
- . Thorax, Vol. 69(Suppl 2) (pp A2-A3)
- . Atherosclerosis, Vol. 237(2) (pp e2-e2)
- . Heart, Vol. 100(Suppl 3) (pp A104.2-A105)
- Bone Marrow Derived Osteoprotegerin Drives Experimental Pulmonary Arterial Hypertension In The Murine Sugen/hypoxia Model. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- . Heart, Vol. 99(suppl 2) (pp A7-A7)
- . Heart, Vol. 99(suppl 2) (pp A99.2-A99)
- . The Lancet, Vol. 381, Supplement 1 (pp S47 --S47 -)
- . HEART, Vol. 98 (pp A1-A1)
- . B26. PULMONARY VASCULAR SIGNALING IN PULMONARY HYPERTENSION
- . D97. PULMONARY HYPERTENSION: NEW INSIGHTS INTO CAUSES AND TREATMENTS?
- . THORAX, Vol. 66 (pp A3-A3)
- . Thorax, Vol. 66(Suppl 4) (pp A34-A34)
- . Heart, Vol. 97(20) (pp e7-e7)
- . HEART, Vol. 97(20) (pp 10-10)
- . B61. PULMONARY HYPERTENSION: EXPERIMENTAL MODELS I
- . THORAX, Vol. 65 (pp A68-A68)
- . A96. INFLAMMATION AND BONE MARROW DERIVED CELLS IN PULMONARY ARTERIAL HYPERTENSION
- . THORAX, Vol. 64 (pp A9-A10)
- . THORAX, Vol. 64 (pp A58-A59)
- . THORAX, Vol. 64 (pp A8-A8)
- . THORAX, Vol. 64 (pp A9-A9)
- . THORAX, Vol. 64 (pp A9-A9)
- . HEART, Vol. 95(22)
- Fat Fed ApoE/IL-1R1 Double Deficient Mice Are Protected From Atherosclerosis but Develop Severe Pulmonary Hypertension. CIRCULATION, Vol. 120(18) (pp S751-S751)
- OPG:TRAIL Ratio as a Potential Biomarker for Pulmonary Arterial Hypertension. CIRCULATION, Vol. 120(18) (pp S806-S806)
- IL-1 MODULATES BLOOD PRESSURE IN MICE AND MAN. ATHEROSCLEROSIS SUPPLEMENTS, Vol. 10(2)
- IL-1 MODULATES BLOOD PRESSURE IN MICE AND MAN. ATHEROSCLEROSIS SUPPLEMENTS, Vol. 10(2). Boston, MA, 14 June 2009 - 18 June 2009.
- A NOVEL MURINE MODEL OF STENTING. HEART, Vol. 95 (pp A37-A38)
- THE OSTEOPROTEGERIN-TNF-RELATED APOPTOSIS-INDUCING LIGAND AXIS IN PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 63 (pp A28-A28)
- Low-density lipoprotein controls IL-8 production in monocytes via tribbles-2. HEART, Vol. 94 (pp A44-A44)
- Leucodepletion filters do not eliminate circulating endothelial cells (CECs) in human whole blood donations. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 141 (pp 113-113)
- The platelet P2Y12 receptor influences the vessel wall response to arterial injury and thrombosis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 51(10) (pp A291-A291)
- A potential role for TRAIL in the pathogenesis of pulmonary arterial hypertension. CIRCULATION, Vol. 116(16) (pp 59-59)
- . Atherosclerosis, Vol. 193(2) (pp S5-S5)
- A potential role for osteoprotegerin in idiopathic pulmonary arterial hypertension. HEART, Vol. 93 (pp A23-A24)
- Bidirectional signalling between monocytes and endothelial cells regulate responses to TLR4 agonists in coculture models of vascular inflammation. JOURNAL OF LEUKOCYTE BIOLOGY (pp 51-51)
- . Vascular Pharmacology, Vol. 45(3) (pp e106-e106)
- Interaction between tumour necrosis factor-related apoptosis inducing ligand & osteoprotegerin in acute coronary syndromes. EUROPEAN HEART JOURNAL, Vol. 27 (pp 229-229)
- The effect of Interleukin-1 receptor antagonist on restenosis - continued suppression of neointima at 90 days. EUROPEAN HEART JOURNAL, Vol. 27 (pp 230-231)
- The P2Y12 receptor regulates the vessel wall response to arterial injury and thrombosis. EUROPEAN HEART JOURNAL, Vol. 27 (pp 753-753)
- The P2Y12 receptor regulates the vessel wall response to arterial injury and thrombosis. HEART, Vol. 92 (pp A111-A111)
- Soluble tumour necrosis factor-related apoptosis inducing ligand is low early in the presentation of acute coronary syndromes and is inversely correlated with C-reactive protein and troponin T. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 47(4) (pp 194A-194A)
- A new murine model of arterial stenting. HEART, Vol. 91 (pp A51-A51)
- Tribbles-1, a mitogen activated protein kinase (MAPK) scaffold regulates inflammation in vascular smooth muscle cells (VSMC) and atherosclerosis. HEART, Vol. 91 (pp A15-A15)
- Investigation of P2X7 dependent mechanisms of interleukin-1 beta (IL-1 beta) release from human endothelial cells. HEART, Vol. 91 (pp A13-A13)
- Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model. CIRCULATION, Vol. 110(17) (pp 161-161)
- Interleukin-1 receptor antagonist (IL-1ra) modulates the porcine coronary arterial response to stenting. ATHEROSCLEROSIS, Vol. 174(1) (pp S4-S4)
- Interleukin 1 receptor antagonist (IL 1ra) modulates the response to oversized balloon angioplasty and stenting in a porcine coronary artery model. HEART, Vol. 90 (pp A1-A2)
- Interleukin-1 receptor antagonist (IL-1ra) modulates the porcine coronary arterial response to oversized balloon angioplasty and stenting. CIRCULATION, Vol. 108(17) (pp 195-195)
- Adjunctive ultrasound exposure enhances gene delivery to vascular smooth muscle cells in vitro and to ex vivo and in vivo porcine saphenous vein grafts. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 92(6A) (pp 100L-100L)
- IL-1 RN (VNTR) gene polymorphism predicts clinical events up to 1 year after a non-ST-elevation acute coronary syndrome: An association independent of troponin T and C-reactive protein. EUROPEAN HEART JOURNAL, Vol. 24 (pp 70-70)
- IL-1RN (VNTR) gene polymorphism predicts a proinflammatory endothelial cell phenotype in HUVEC-Implications for atherogenesis and plaque rupture. EUROPEAN HEART JOURNAL, Vol. 23 (pp 594-594)
- Modulation of MSS1, a component of the 26S proteasome, in vascular smooth muscle cells in vitro and following experimental PTCA. EUR HEART J, Vol. 22 (pp 3-3)
- Ultrasound-enhanced reporter gene expression following naked DNA transfection is markedly enhanced by the presence of microbubble contrast agents.. AM J CARDIOL, Vol. 84(6A) (pp 64P-65P)
- IL-1 beta synthesis and neovascularisation following porcine coronary arterial injury. J VASC RES, Vol. 35(5) (pp 389-389)
- . Journal of the American College of Cardiology, Vol. 31 (pp 25-25)
- Is local drug delivery truly a low efficiency procedure?. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 80 (pp TC240-TC240)
- . Biochemical Society Transactions, Vol. 18(5) (pp 876-877)
- . Diseases, Vol. 2(3) (pp 260-273)
- Neutrophil elastase enhances IL-1 beta secretion from coronary endothelium via an endolysosomal mediated mechanism, without caspase-1 activation. ANGIOGENESIS, Vol. 17(4) (pp 941-941). California, USA, 18 October 2014 - 23 October 2014.
Preprints
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- High resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators, arXiv.
- , Research Square Platform LLC.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- .
- , Cold Spring Harbor Laboratory.
- .
- Research group
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- Dr Osman Shabir
- Dr Aya Elwazir
- Mr Kieran Bowden
- Miss Pooja Atul Patel
- Dr Janet Chamberlain
- Mr David Reid (with the Paul Evans group)
- Ms Priscila Hirschfield (with the Paul Evans group)
- Mr Oliver Heaney ( with the Shaw group)
- Mr Rahul Sidhu ( with the Howarth/Berwick group)
- Teaching interests
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I am a Senior Fellow of the Higher Education Academy. I teach the MSc in Molecular Medicine, where I lead Molecular Genetics of Human Diseases (MED6003). I also teach phase 2a (Cardiology) MBChB.
I co-founded an undergraduate BMS 3rd year module 鈥楥ardiovascular Pharmacology 鈥 personalising medicine鈥 now led by Dr Janet Chamberlain and Dr Nigel Wheeldon.
- Professional activities and memberships
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- Secretary of the (September 2018 - September 2023)
- European Atherosclerosis Society Distinguished Awards and Prizes Committee (2022 - present)
- Fellowships Committee, British Heart Foundation (July 2020 - present)
- Academy of Medical Sciences, Springboard Awards Committee (November 2022 - present)