Professor Endre Kiss-Toth
Clinical Medicine, School of Medicine and Population Health
School Director of Innovation
Professor of Cell Signalling
+44 114 215 9534
Full contact details
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
91直播
S10 2RX
- Profile
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For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
I joined the University of 91直播 in 1988 as a postdoctoral researcher and was working on the development and implementation of a novel genetic screening approach.
This is based on detecting the bioactivity of proteins, which are transiently over expressed in mammalian cells. We used this approach to identify novel components of signalling pathways key in innate immunity. I have kept interest and association with this screening platform ever since and have recently been leading research identifying novel inflammatory regulators of macrophages.
In 2000, I was awarded a Career Development Fellowship by the Arthritis Research Campaign (now AR-UK) to characterise the mode of action of a novel family of proteins, tribbles.
In 2002, I joined the Cardiovascular Research Group as a Lecturer and developed my interest in tribbles further, by investigating their biological importance in vascular cells.
I became a Reader in 2013 and a Professor in 2017 with the same overall focus around regulation of innate immune signalling.
- Research interests
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My group is interested in identifying novel regulators of inflammatory signal transduction, characterising their basic mechanism of action, as well as validating some of these novel genes as potential drug targets for therapeutic intervention in chronic inflammatory diseases.
Much of our recent work has been focussing on studying the biological importance of the tribbles family of pseudokinases in cell types that are relevant to the development of cardiovascular disease.
We have established a global network of collaborators to pursue joint projects that aim to understand the importance of tribbles in cell biology, both in health and disease.
Current projects
- Discovery of novel regulators of inflammatory signalling.
- Defining the molecular mechanism of action for TMEM203, a novel inflammatory signalling regulator.
- Characterisation the biological importance of tribbles proteins in the development of lipid homeostasis, inflammation and metabolic syndromes
- Regulation of tribbles expression in vascular cells: development of novel anti-atherosclerotic drug targeting strategies.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . PLoS ONE, 8(9).
- . Biochim Biophys Acta, 1831(10), 1573-1578.
- . J Biol Chem, 288(14), 10051-10060.
- . PLoS One, 7(7), e42388.
- . Curr Opin Lipidol, 23(2), 122-126.
- . Biochem Soc Trans, 39(2), 684-687.
- TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappa B (vol 285, pg 7222, 2010). J BIOL CHEM, 285(23), 18122-18122.
- . Immunol Lett, 130(1-2), 115-124.
- . J Orthop Res, 28(9), 1127-1135.
- . Int Immunol, 20(12), 1543-1550.
- . J Biol Chem, 282(25), 18379-18387.
- . Cell Signal, 19(2), 238-250.
- . Cell Mol Life Sci, 63(14), 1632-1641.
- . Immunol Lett, 104(1-2), 171-177.
- . Cell Signal, 18(2), 202-214.
All publications
Journal articles
- . Atherosclerosis, 395, 118481-118481.
- . Cell Reports, 43(4), 114073-114073.
- . Molecular Metabolism, 78.
- . Frontiers in Immunology, 14.
- . International Journal of Molecular Sciences, 23(16).
- . Theranostics, 12(8), 3584-3600.
- . ERJ Open Research.
- . Cancers, 13(24).
- . Cancers, 12(9).
- . Frontiers in Veterinary Science, 7.
- . Atherosclerosis.
- . Nature Communications, 11(1).
- . Science Advances, 5(10).
- . Proceedings of the National Academy of Sciences.
- . Cardiovascular Research, 114(14), 1845-1847.
- . JACC - Journal of the American College of Cardiology bts, 2(4), 398-414.
- . Scientific Reports, 7.
- . J Inflamm (Lond), 14, 11-11.
- . Nature Communications, 8.
- Characterization and therapeutic application of canine adipose mesenchymal stem cells to treat elbow osteoarthritis. Canadian Journal of Veterinary Research, 8(1), 73-78.
- . Scientific Reports, 6.
- . Scientific Reports, 6.
- . PLOS One, 11(5).
- . The Journal of Bone and Joint Surgery, 98(4), 285-294.
- . Biochemical Society Transactions, 43(5), 1069-1074.
- . Biochemical Society Transactions, 43(5), 1049-1050.
- . Biochemical Society Transactions, 43(5), 1116-1121.
- . Biochemical Society Transactions, 43(5), 1122-1126.
- . Molecular & Cellular Oncology, 2(3).
- . Journal of Orthopaedic Research, 33(2), 193-198.
- . Cell Death & Differentiation, 22(1), 131-144.
- . Heart, 100 Suppl 3, A117.
- . PLoS ONE, 8(9).
- Characterization of four novel beta 3 integrin defects associated with Glanzmann's thrombasthenia. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, 224-224.
- . Biochim Biophys Acta, 1831(10), 1573-1578.
- . J Biol Chem, 288(14), 10051-10060.
- . Genesis, 51(1), 41-49.
- The Tribbles-1 protein in humans: roles and functions in health and disease.. Curr Mol Med, 13(1), 80-85.
- . Biology (Basel), 1(1), 43-57.
- Bioinformatics Analysis of the FREM1 Gene鈥擡volutionary Development of the IL-1R1 Co-Receptor, TILRR. Biology, 1(3), 484-494.
- . PLoS One, 7(7), e42388.
- . J Biol Chem, 287(15), 12348-12352.
- . Curr Opin Lipidol, 23(2), 122-126.
- . Biochem Soc Trans, 39(2), 684-687.
- . Cytokine, 56(3), 792-797.
- TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappa B (vol 285, pg 7222, 2010). J BIOL CHEM, 285(23), 18122-18122.
- . Immunol Lett, 130(1-2), 115-124.
- . J Orthop Res, 28(9), 1127-1135.
- . J Biol Chem, 285(10), 7222-7232.
- . Arthritis Rheum, 60(12), 3856-3857.
- . Vaccine, 27(41), 5589-5598.
- . Int Immunol, 20(12), 1543-1550.
- . Arthritis Rheum, 58(10), 3157-3165.
- . Immunol Lett, 116(2), 178-183.
- . J Immunol Methods, 330(1-2), 96-108.
- . Adv Biochem Eng Biotechnol, 110, 1-24.
- . J Biol Chem, 282(25), 18379-18387.
- . Cell Signal, 19(2), 238-250.
- . Methods Mol Biol, 411, 111-119.
- . Cell Immunol, 244(2), 158-161.
- . Cell Mol Life Sci, 63(14), 1632-1641.
- . Immunol Lett, 104(1-2), 171-177.
- . Cell Signal, 18(2), 202-214.
- . Biochemical Society Transactions, 33(6), 1405-1405.
- . Ann N Y Acad Sci, 1051, 515-528.
- . J Biol Chem, 279(41), 42703-42708.
- . Cytokine Growth Factor Rev, 15(2-3), 97-102.
- . Ultrasound Med Biol, 29(10), 1453-1461.
- . Current Genomics, 3(3), 139-148.
- . Immunity, 15(5), 825-835.
- . J Biol Chem, 276(9), 6280-6288.
- . Anal Biochem, 288(2), 230-232.
- . J Immunol, 165(12), 7125-7132.
- . Proc Natl Acad Sci U S A, 97(18), 10162-10167.
- . J Immunol Methods, 239(1-2), 125-135.
- Evidence for an accessory protein function for the Toll-like receptor TLR1 in lipopolysaccharide responses. FASEB J, 14(6), A1032-A1032.
- . Eur J Immunol, 28(5), 1701-1707.
- . Nucleic Acids Res, 22(23), 4872-4875.
- . Biochem Biophys Res Commun, 202(3), 1553-1561.
- . Nucleic Acids Res, 21(16), 3677-3682.
- . Molecular Microbiology.
- . Journal of Translational Genetics and Genomics, 8(2), 225-43.
- . eLife, 13.
- . Genes, 15(1), 26-26.
- . Biological Procedures Online, 25(1).
- . Nature Communications, 14(1).
- . Frontiers in Cardiovascular Medicine, 9.
- . International Journal of Molecular Sciences, 23(13), 6983-6983.
- . Frontiers in Immunology, 11.
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Chapters
Conference proceedings papers
- . Basic science
- . Basic science
- . Basic Science
- . Basic Science
- . Heart, Vol. 107(Suppl 1) (pp a156-a156)
- . Atherosclerosis, Vol. 241(1) (pp e34-e34)
- . Heart, Vol. 101(Suppl 4) (pp A121.2-A121)
- . Heart, Vol. 101(Suppl 4) (pp A101.2-A102)
- . Heart, Vol. 101(Suppl 4) (pp A104.2-A105)
- . HEART, Vol. 99 (pp A126-A126)
- Tribbles-1 is expressed by regulatory T cells and interacts with FOXP3. IMMUNOLOGY, Vol. 137 (pp 418-418)
- Tribbles-1 Is Expressed by Regulatory T Cells and Interacts with Foxp3. AMERICAN JOURNAL OF TRANSPLANTATION, Vol. 12 (pp 445-445)
- Tribbles-1 Is Expressed by Regulatory T Cells and Interacts with FOXP3. AMERICAN JOURNAL OF TRANSPLANTATION, Vol. 10 (pp 363-363)
- . HEART, Vol. 95(22)
- Low-density lipoprotein controls IL-8 production in monocytes via tribbles-2. HEART, Vol. 94 (pp A44-A44)
- . CYTOKINE, Vol. 39(1) (pp 13-13)
- Tribbles-1, a mitogen activated protein kinase (MAPK) scaffold regulates inflammation in vascular smooth muscle cells (VSMC) and atherosclerosis. HEART, Vol. 91 (pp A15-A15)
- A single nucleotide polymorphism at-238 in the TNF gene influences promoter activity in-vitro. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 17 (pp S237-S237)
- Detectability of prunus necrotic ringspot and plum pox viruses by RT-PCR, multiplex RT-PCR, ELISA and indexing on woody indicators. 17TH INTERNATIONAL SYMPOSIUM ON VIRUS AND VIRUS-LIKE DISEASES OF TEMPERATE FRUIT CROPS: FRUIT TREE DISEASES, VOLS 1 AND 2(472) (pp 243-247)
- Detection of plum pox virus by different methods. DIAGNOSIS AND IDENTIFICATION OF PLANT PATHOGENS, Vol. 11 (pp 317-319)
- REGULATION OF THE BOVINE LEUKEMIA-VIRUS BASAL TRANSCRIPTION. JOURNAL OF CELLULAR BIOCHEMISTRY (pp 48-48)
- THE INVIVO ROLE OF CREB-ALPHA ON HTLV-I AND BLV PROMOTERS. JOURNAL OF CELLULAR BIOCHEMISTRY (pp 24-24)
- PROTEIN AND DNA ELEMENTS INVOLVED IN THE TRANSCRIPTIONAL TRANSACTIVATION OF BLV. JOURNAL OF CELLULAR BIOCHEMISTRY (pp 131-131)
Preprints
- Research group
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- Kajus Baidzajevas
- Eva Hadadi
- Zabran Ilyas
- Jessica Johnston
- Li Yang
- Teaching interests
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I lecture on technologies and approaches designed to identify novel genes with a particular function. My other main area of teaching involves bioinformatics for molecular biology and functional genomics applications.