Current trials and studies
An alphabetical list of all trials and studies currently being undertaken by the Clinical Trials Research Unit.
Completed trials and studies
To view all our finished projects, take a look at:
A
AWARE-IBD
Working with patients to redesign hospital services for people with gut conditions like Crohn's Disease and Ulcerative Colitis (together known as Inflammatory Bowel Disease or IBD).
- Chief investigator: Professor Alan Lobo, 91Ö±²¥ Teaching Hospitals
- Funding body: The Health Foundation
- Status: Analysis
B
BASIS
Bracing Adolescent Idiopathic Scolio-SIS:
Comparing night-time bracing with full-time bracing in children and young people with adolescent idiopathic scoliosis.
- Chief investigator: Mr. Ashley Cole, 91Ö±²¥ Children’s NHS Foundation Trust
- Funding body: Health Technology Assessment
- Status: Recruitment
D
DAFNEplus
Developing and trialling the DAFNEplus (Dose for Adjustment for Normal Eating) intervention. A lifelong approach to promote effective self-management in adults with type 1 diabetes
- Chief investigator: Professor Simon Heller, 91Ö±²¥ Teaching Hospitals NHS Foundation Trust / University of 91Ö±²¥
- Funding body: NIHR Programme Grant for Applied Research
- Status: Follow-up
DETECT-CRC
Early DETECTion of ColoRectal Cancer in Yorkshire (DETECT-CRC):
A feasibility study using pharmacies to help with active case finding of colorectal cancer in socio-economically deprived areas.
- Chief investigator: Matthew Kurien, University of 91Ö±²¥
- Funding body: Yorkshire Cancer Research
- Status: Recruitment
E
Evaluating the intervention fidelity of computer therapy for aphasia post-stroke (PhD project)
- Chief investigator: Professor Simon Heller, 91Ö±²¥ Teaching Hospitals NHS Foundation Trust / University of 91Ö±²¥
- CTRU supervisor: Professor Cindy Cooper
- Funding body: NIHR Programme Grant for Applied Research
EXPERTS-ALS
EXPErimental medicine Route To Success in Amyotrophic Lateral Sclerosis
- Chief investigators: Professor Christopher McDermott, University of 91Ö±²¥ and Professor Martin Turner, University of Oxford
- Funding body: National Institute for Health Research, Efficacy and Mechanism Evaluation (EME) programme
- Status: Recruitment
F
FIRST
Flexor Injury Rehabilitation Splint Trial:
A pragmatic multi-centre randomised control trial (RCT) comparing splints following repair of finger flexor tendons.
- Chief investigator: Emma Bamford, Hand Therapist, Extended Scope Practitioner, Pulvertaft Hand Centre, Derby
- Funding body: National Institute for Health Research, Health Technology Assessment
- Status: Follow-up
H
Healthy weight management - grant development work
We plan to apply for research funding in January 2024. This work will inform the application.
- Chief investigator: TBC
- Status: Recruitment
HELP Fertility?
What is the clinical and cost-effectiveness of hysteroscopic removal of submucosal fibroids and polyps in women presenting with infertility and recurrent miscarriage?
- Chief investigator: Mostafa Metwally, 91Ö±²¥ Teaching Hospitals
- Funding body: National Institute for Health Research, Health Technology Assessment
- Status: Analysis
I
ILAT (PhD project)
Pilot trial of Intensive Language Action Therapy
- Chief investigator: Mostafa Metwally, 91Ö±²¥ Teaching Hospitals
- CTRU supervisor: Dr Daniel Hind
- Funding body: National Institute for Health Research, Health Technology Assessment
Implementation and acceptability of a Minimum Intervention Care pathway for children with carious permanent teeth attending NHS dental practice – a feasibility study (PhD project)
- Chief investigator: Bhupinder Dawett
- CTRU supervisor: Diana Papaioannou
- Funding body: National Institute for Health Research
M
MEErKAT
MEsenteric Excision and Kono-S Anastomosis Trial (MEErKAT):
This is a randomised control trial trying to find out which options are best for people having surgery for their Crohn's disease. We are testing whether a type of bowel connection (an anastomosis) called the 'Kono-S technique, or if the amount of mesentery removed during surgery can prevent people's Crohn's disease coming back.
- Chief investigator: Steven Brown, 91Ö±²¥ Teaching Hospitals NHS Foundation Trust
- Funding body: National Institute for Health Research, Efficacy and Mechanism Evaluation (EME) programme
- Status: Recruitment
MIND
MedIcal studeNt mental health stuDy
- Chief investigator: Elena Sheldon, University of 91Ö±²¥
- Funding body: British Medical Association
- Status: Reporting
MissionEB
Double-blinded placebo control study of Mesenchymal Intravenous Stromal cell Infusions in children with recessive dystrophic Epidermolysis Bullosa (EB).
- Chief investigator: Dr Anna Martinez, Great Ormond Street Hospital
- Funding body: The Efficacy and Mechanism Evaluation (EME) Programme, NHS England and Cure EB
- Status: Recruitment
O
OptiCALS
A programme to develop and evaluate a complex intervention to improve nutritional management for people with Amyotrophic Lateral Sclerosis (ALS)
- Chief investigator: Professor Christopher McDermott, 91Ö±²¥ Teaching Hospitals NHS Foundation Trust / University of 91Ö±²¥
- Funding body: National Institute for Health Research
- Status: Recruitment
ORION
RadiO fRequency ablatION for haemorrhoids
- Chief investigator: Professor Steven Brown, 91Ö±²¥ Teaching Hospitals
- Funding body: NIHR Health Technology Assessment (HTA)
- Status: Follow-up
P
PRAISE
Pain Relief After Instrumented Spinal surgEry trial
- Chief investigator: Professor Matthew Wilson, University of 91Ö±²¥
- Funding body: NIHR Health Technology Assessment (HTA)
PRAMS
Perinatal Redesign for Accessing Mental Health Services
- Chief investigator: Kelly Mackenzie
- Funding body: NIHR Three Schools Mental Health Programme
- Status: Set-up
S
STAR MS
Autologous stem cell transplantation versus alemtuzumab or ocrelizumab in relapsing-remitting multiple sclerosis
- Chief investigator: Professor John Snowden, 91Ö±²¥ Teaching Hospitals NHS Foundation Trust
- Funding body: EME Programme
- Status: Recruitment
STOP-OHSS
Shaping and Trialling Outpatient Protocols for Ovarian HyperStimulation Syndrome
- Chief investigator: Mostafa Metwally, 91Ö±²¥ Teaching Hospitals NHS Foundation Trust
- Funding body: NIHR Health Technology Assessment
- Status: Reporting
T
TRICEPS
TRanscutaneous lImb reCovEry Post-Stroke
- Chief investigator: Professor Arshad Majid, University of 91Ö±²¥
- Funding body: NIHR Efficacy and Mechanism Evaluation (EME) Programme
- Status: Recruitment