Dr Sophie Whyte

MMath (Warwick), PhD (Birmingham)

Population Health, School of Medicine and Population Health

Senior Research Fellow

sophie.whyte@sheffield.ac.uk
+44 114 222 0859

Full contact details

Dr Sophie Whyte
Population Health, School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
91直播
S1 4DA
Profile

I joined the HEDS section of ScHARR as a mathematical modeller in September 2007. Previous to this, I obtained a Masters in Mathematics from the University of Warwick and a PhD in Pure Mathematics (Group Theory) from Birmingham University.

Research interests

My broad research is focused on mathematical modelling within health economics. I have gained significant expertise and experience in two related areas:

  • Bayesian calibration of cancer natural history models: This is my main methodological research theme, please see MDM publication  and Example Excel model using the Metropolis Hastings algorithm to calibrate a state transition model available to down load from the Downloads box)
  • Early diagnosis of bowel cancer: I have substantial experience in early diagnosis of cancer generally having worked on more than 15 projects in this area of applied research. My main expertise lies in the modelling bowel cancer screening to inform national bowel cancer screening policy.

In addition to these main research themes I have undertaken research to inform policy making: Health Technology Assessment (HTA) for NICE, and research as part of the Policy Research Unit in Economic Evaluation of Health and Care Interventions (EEPRU) for DH ()

Publications

Show: Featured publications All publications

Journal articles

  • Whyte S, Thomas C, Chilcott J & Kearns B (2022) . Value in Health, 25(6), 954-964. RIS download Bibtex download
  • Rutter MD, East J, Rees CJ, Cripps N, Docherty J, Dolwani S, Kaye PV, Monahan KJ, Novelli MR, Plumb A , Saunders BP et al (2019) . Gut, 69(2), 201-223. RIS download Bibtex download
  • Kearns B, Chilcott J, Relton C, Whyte S, Woods HB, Nickerson C & Loban A (2018) . Cancer Management and Research, 10, 637-645. RIS download Bibtex download
  • Asaria M, Griffin S, Cookson R, Whyte S & Tappenden P (2015) . Health Economics, 24(6), 742-754. RIS download Bibtex download
  • Kearns B, Whyte S, Chilcott J & Patnick J (2014) . British Journal of Cancer, 111(9), 1734-1741. RIS download Bibtex download
  • Whyte S & Harnan S (2014) . Cancer Causes Control, 25(6), 647-658. RIS download Bibtex download
  • Whyte S, Pandor A & Stevenson M (2012) . Pharmacoeconomics, 30(12), 1119-1132. RIS download Bibtex download
  • Whyte S, Chilcott J & Halloran S (2012) . Colorectal Dis, 14(9), e547-e561. RIS download Bibtex download
  • Sharp L, Tilson L, Whyte S, O'Ceilleachair A, Walsh C, Usher C, Tappenden P, Chilcott J, Staines A, Barry M & Comber H (2012) . Br J Cancer, 106(5), 805-816. RIS download Bibtex download
  • Madan J, Stevenson MD, Cooper KL, Ades AE, Whyte S & Akehurst R (2011) . Value Health, 14(6), 953-960. RIS download Bibtex download
  • Whyte S, Cooper KL, Stevenson MD, Madan J & Akehurst R (2011) . Value Health, 14(4), 465-474. RIS download Bibtex download
  • Whyte S, Walsh C & Chilcott J (2011) . Medical Decision Making, 31(4), 625-641. RIS download Bibtex download
  • Whyte S, Pandor A, Stevenson M & Rees A (2010) . Health Technol Assess, 14(Suppl. 2), 47-53. RIS download Bibtex download
  • Whyte S, Walsh C, Sharp L, O'Ceilleachair A, Tilson L, Usher C, Chilcott J, Tappenden P, Staines A, Comber H & Barry M (2009) . Value in Health, 12(7), A395-A395. RIS download Bibtex download

Reports

  • Whyte S, Chilcott J, Essat M, Stevens J, Wong R & Kalita N (2011) Reappraisal of the options for colorectal cancer screening RIS download Bibtex download

All publications

Journal articles

  • Needham KJ, Tappenden P, Gillespie D & Whyte S (2023) . Journal of Thoracic Oncology, 18(11), S134-S134. RIS download Bibtex download
  • Whyte S, Thomas C, Chilcott J & Kearns B (2022) . Value in Health, 25(6), 954-964. RIS download Bibtex download
  • Thomas C, Mandrik O, Saunders CL, Thompson D, Whyte S, Griffin S & Usher-Smith JA (2021) . Cancer Prevention Research, 14(8), 811-822. RIS download Bibtex download
  • Rubin G, Walter FM, Emery J, Hamilton W, Hoare Z, Howse J, Nixon C, Srivastava T, Thomas C, Ukoumunne OC , Usher-Smith JA et al (2021) . BMJ Open, 11(3). RIS download Bibtex download
  • Rutter MD, Bretthauer M, Hassan C, Jover R, Adami H-O, Corley DA, Cubiella J, Cross AJ, Evelien Dekker PD, Gupta S , Kalager M et al (2020) . Gastroenterology, 158(6), 1529-1533.e4. RIS download Bibtex download
  • Rutter MD, East J, Rees CJ, Cripps N, Docherty J, Dolwani S, Kaye PV, Monahan KJ, Novelli MR, Plumb A , Saunders BP et al (2019) . Gut, 69(2), 201-223. RIS download Bibtex download
  • Thomas C, Whyte S, Kearns B & Chilcott JB (2019) . Value in Health, 22(10), 1154-1161. RIS download Bibtex download
  • Kearns B, Chilcott J, Relton C, Whyte S, Woods HB, Nickerson C & Loban A (2018) . Cancer Management and Research, 10, 637-645. RIS download Bibtex download
  • Picot J, Rose M, Cooper K, Pickett K, Lord J, Harris P, Whyte S, B枚hning D & Shepherd J (2017) . Health Technology Assessment, 21(79), 1-308. RIS download Bibtex download
  • Ren S, Minton J, Whyte S, Latimer N & Stevenson M (2017) . PharmacoEconomics. RIS download Bibtex download
  • Uttley L, Whyte S, Gomersall T, Ren S, Wong R, Chambers D & Tappenden P (2017) . PharmacoEconomics, 35(7), 717-726. RIS download Bibtex download
  • Faria R, Walker S, Whyte S, Dixon S, Palmer S & Sculpher M (2017) . Medical Decision Making, 37(2), 148-161. RIS download Bibtex download
  • Kearns B, Chilcott J, Whyte S, Preston L & Sadler S (2017) . BMC Medicine, 15(1). RIS download Bibtex download
  • Kearns B, Chilcott J, Whyte S, Preston L & Sadler S (2016) . BMC Medicine, 14(1), 200-200. RIS download Bibtex download
  • Moore HJ, Nixon C, Tariq A, Emery J, Hamilton W, Hoare Z, Kershenbaum A, Neal RD, Ukoumunne OC, Usher-Smith J , Walter FM et al (2016) . Trials, 17(1). RIS download Bibtex download
  • Whyte S, Dixon S, Faria R, Walker S, Palmer S, Sculpher M & Radford S (2016) . Value in Health, 19(2), 138-144. RIS download Bibtex download
  • Kearns B, Whyte S, Seaman HE, Snowball J, Halloran SP, Butler P, Patnick J, Nickerson C & Chilcott J (2016) . British Journal of Cancer, 114(3), 327-333. RIS download Bibtex download
  • Rowen D, Brazier J, Mukuria C, Keetharuth A, Risa Hole A, Tsuchiya A, Whyte S & Shackley P (2016) . Medical Decision Making, 36(2), 210-222. RIS download Bibtex download
  • Hinde S, McKenna C, Whyte S, Peake MD, Callister MEJ, Rogers T & Sculpher M (2015) . British Journal of Cancer, 113(1), 135-141. RIS download Bibtex download
  • Asaria M, Griffin S, Cookson R, Whyte S & Tappenden P (2015) . Health Economics, 24(6), 742-754. RIS download Bibtex download
  • Kearns B, Whyte S, Chilcott J & Patnick J (2014) . British Journal of Cancer, 111(9), 1734-1741. RIS download Bibtex download
  • Whyte S & Harnan S (2014) . Cancer Causes Control, 25(6), 647-658. RIS download Bibtex download
  • Asaria M, Griffin S, Cookson R, Tappenden P & Whyte S (2013) . VALUE IN HEALTH, 16(7), A426-A426. RIS download Bibtex download
  • Sharp L, Tilson L, Whyte S, Ceilleachair AO, Walsh C, Usher C, Tappenden P, Chilcott J, Staines A, Barry M & Comber H (2013) . BMC Health Serv Res, 13, 105. RIS download Bibtex download
  • Sharp L, Walsh C, Whyte S, Tilson L, O'Ceilleachair A, Usher C, Tappenden P, Chilcott J, Staines A, Barry M & Comber H (2013) . British Journal of Cancer, 108(5), 1211-1212. RIS download Bibtex download
  • Whyte S, Pandor A & Stevenson M (2012) . Pharmacoeconomics, 30(12), 1119-1132. RIS download Bibtex download
  • Whyte S, Chilcott J & Halloran S (2012) . Colorectal Dis, 14(9), e547-e561. RIS download Bibtex download
  • Sharp L, Tilson L, Whyte S, O'Ceilleachair A, Walsh C, Usher C, Tappenden P, Chilcott J, Staines A, Barry M & Comber H (2012) . Br J Cancer, 106(5), 805-816. RIS download Bibtex download
  • Tilson L, Sharp L, Usher C, Walsh C, Whyte S, O'Ceilleachair A, Stuart C, Mehigan B, Kennedy MJ, Tappenden P , Chilcott J et al (2012) . European Journal of Health Economics, 13(4), 511-524. RIS download Bibtex download
  • Madan J, Stevenson MD, Cooper KL, Ades AE, Whyte S & Akehurst R (2011) . Value Health, 14(6), 953-960. RIS download Bibtex download
  • Whyte S, Cooper KL, Stevenson MD, Madan J & Akehurst R (2011) . Value Health, 14(4), 465-474. RIS download Bibtex download
  • Cooper KL, Madan J, Whyte S, Stevenson MD & Akehurst RL (2011) . BMC Cancer, 11. RIS download Bibtex download
  • Whyte S, Walsh C & Chilcott J (2011) . Medical Decision Making, 31(4), 625-641. RIS download Bibtex download
  • Whyte S, Pandor A, Stevenson M & Rees A (2010) . Health Technol Assess, 14(Suppl. 2), 47-53. RIS download Bibtex download
  • Whyte S, Walsh C, Sharp L, O'Ceilleachair A, Tilson L, Usher C, Chilcott J, Tappenden P, Staines A, Comber H & Barry M (2009) . Value in Health, 12(7), A395-A395. RIS download Bibtex download
  • Sharp L, Tilson L, Whyte S, O'Ceilleachair A, Walsh C, Usher C, Tappenden P, Chilcott J, Staines A, Comber H & Barry M (2009) COST-EFFECTIVENESS OF A POPULATION-BASED COLORECTAL CANCER SCREENING PROGRAMME IN IRELAND. VALUE HEALTH, 12(7), A280-A280. RIS download Bibtex download
  • Harnan S, Hamilton J, Simpson E, Clowes M, Navega Biz A, Whyte S, Ren S, Cooper K, Abulafi M, Ball A , Beton S et al () Faecal Immunochemical Tests For Patients With Symptoms Suggestive Of Colorectal Cancer: An Updated Systematic Review And Multiple-Threshold Meta-Analysis of Diagnostic Test Accuracy Studies. Colorectal Disease. RIS download Bibtex download
  • Thomas C, Mandrik O & Whyte S () Modelling cost-effective strategies for minimising socioeconomic inequalities in colorectal cancer screening outcomes in England. Preventive Medicine. RIS download Bibtex download
  • Thomas C, Mandrik O, Whyte S, Saunders CL, Griffin SJ & Usher鈥怱mith JA () . Cancer Reports. RIS download Bibtex download
  • Whyte S, Pandor A, Stevenson M & Rees A () . Health Technology Assessment, 14(Suppl 2), 47-53. RIS download Bibtex download
  • Mandrik O, Thomas C, Whyte S & Chilcott J () CALIBRATING NATURAL HISTORY OF CANCER MODELS IN THE PRESENCE OF DATA INCOMPATIBILITY; PROBLEMS AND SOLUTIONS. PharmacoEconomics. RIS download Bibtex download

Conference proceedings papers

  • Needham KJ, Tappenden P, Gillespie D & Whyte S (2023) Model-based Evaluations of the Cost-effectiveness of Interventions for Lung Cancer: A Systematic Review. JOURNAL OF THORACIC ONCOLOGY, Vol. 18(11) (pp S134-S134) RIS download Bibtex download
  • Kearns B, Chilcott & whyte (2016) Flexible parametric survival models and time-series analysis for extrapolating time-varying treatment effects in health technology assessment. Flexible parametric survival models and time-series analysis for extrapolating time-varying treatment effects in health technology assessment, 5 September 2016 - 8 September 2016. RIS download Bibtex download
  • Faria R, Walker S, Whyte S, Dixon S, Sculpher M & Palmer S (2015) The value of implementation: how to invest in getting cost-effective technologies into practice. Framework and application to novel oral anticoagulants in the prevention of stroke and systemic embolism. HESG. Leeds RIS download Bibtex download
  • Faria R, Whyte S, Palmer S & Hoomans T (2014) WORKSHOP 2999: From evaluation to implementation: how to ensure efficient investment in implementation of cost-effective technologies in clinical practice?. ISPOR. Amsterdam, 9 November 2014 - 12 November 2014. RIS download Bibtex download
  • Rowen D, Brazier J, Mukuria C, Whyte S, Keetharuth A, Risa Hole A, Tsuchiya A & Shackley P (2014) Rowen D, Brazier J, Mukuria C, Whyte S, Keetharuth A, Risa Hole A, Tsuchiya A, Shackley P. Eliciting societal preferences for burden of illness, therapeutic improvement and end of life for value based pricing.. HESG. 91直播, UK, 8 January 2014. RIS download Bibtex download
  • Asaria M, Griffin S, Cookson R, Whyte S & Tappenden P (2013) A framework for the cost-equality analysis of health care programmes. ISPOR. Dublin RIS download Bibtex download
  • Bessey A, Whyte S, Minton J & Chilcott J (2013) Economic evaluation of an electrical impedance spectroscopy (EIS) device used as an adjunct to colposcopy. VALUE IN HEALTH, Vol. 16(7) (pp A407-A407) RIS download Bibtex download
  • Whyte S (2013) Cost effectiveness analysis of an early awareness campaign for colorectal cancer. Cancer Outcomes Conference. Brighton RIS download Bibtex download
  • Whyte S (2013) Effectiveness and cost effectiveness of an awareness campaign for colorectal cancer: A mathematical modelling study. Cancer Research UK NAEDI conference. Cambridge, UK RIS download Bibtex download
  • Whyte S (2012) The cost effectiveness of an early awareness campaign for colorectal cancer. SMDM. Oslo, Norway, 10 June 2012 - 12 June 2012. RIS download Bibtex download
  • Whyte S, Scope A & Tappenden P (2012) The cost effectiveness of an early awareness campaign for colorectal cancer. SMDM. Oslo, Norway RIS download Bibtex download
  • Whyte S & Chilcott J (2010) Using a natural history model in combination with screening data to estimate the test characteristics of the FOB test in the English bowel cancer screening programme. Methods for evaluating medical tests and biomarkers. Birmingham, UK RIS download Bibtex download
  • Whyte S (2009) Bayesian calibration of a natural history model for colorectal cancer. ISPOR. Paris RIS download Bibtex download
  • Whyte S, Dixon S, Faria R, Walker S, Sculpher M & Palmer S () RIS download Bibtex download

Reports

  • Srivastava T, Chambers D, Thomas C & Whyte S (2019) ECASS health economic feasibility study RIS download Bibtex download
  • Whyte S, Thomas C, Kearns B, Webster M & Chilcott J (2017) Optimising Bowel Cancer Screening Phase 1: Optimising the cost effectiveness of repeated FIT screening and screening strategies combining bowel scope and FIT screening RIS download Bibtex download
  • Pollard D, Cree I & Whyte S (2016) Generic Cancer Screen - Economic modelling report RIS download Bibtex download
  • Whyte S, Chambers D & Wong R (2015) Degarelix for treating advanced hormone-dependent Prostate cancer [ID590] Spinal cord compression associated with hormonal therapy in men with hormone-dependent metastatic prostate cancer: a systematic review and economic assessment RIS download Bibtex download
  • Faria R, Walker S, Whyte S, Dixon S, Palmer S & Sculpher M (2014) Getting cost-effective technologies into practice: the value of implementation An application to novel anticoagulants in the prevention of stroke and systemic embolism RIS download Bibtex download
  • Whyte S, Dixon S, Faria R, Walker S, Palmer S & Sculpher M (2014) Getting cost-effective technologies into practice: the value of implementation. An application to B-type natriuretic peptide (BNP) testing in diagnosing chronic heart failure RIS download Bibtex download
  • Walker S, Faria R, Whyte S, Dixon S, Palmer S & Sculpher M (2014) Getting cost-effective technologies into practice: the value of implementation. Report on framework for valuing implementation initiatives RIS download Bibtex download
  • Rowen D, Brazier J, Mukuria C, Keetharuth A, Rise Hole A, Tsuchiya A, Whyte S & Shackley P (2014) Update: Eliciting societal preferences for weighting QALY's according to burden of illness, size of gain and end of life RIS download Bibtex download
  • Whyte S, Brazier J, Rowen D, Mukuria C, Keetharuth A, RiseHole A, Tsuchiya A & Shackley P (2013) Eliciting societal preferences for burden of illness, therapeutic improvement and end of life for value based pricing: a report of the main survey RIS download Bibtex download
  • Hinde S, McKenna C, Whyte S, Peake M, Callister M, Rogers T & Sculpher M (2012) Modelling the cost-effectiveness of early awareness interventions for the early detection of lung cancer RIS download Bibtex download
  • Whyte S, Harnan S, Scope A, Simpson E, Tappenden P, Duffy S, Rachet B, Sculpher M, Hinde S, McKenna C & Wong R (2012) Early awareness interventions for cancer: Colorectal cancer RIS download Bibtex download
  • Whyte S, Cooper KL, Stevenson MD, Madan J & Akehurst R (2011) Cost-effectiveness of granulocyte colony-stimulating factor prophylaxis for febrile neutropenia in breast cancer in the United Kingdom RIS download Bibtex download
  • Whyte S, Cooper KL, Stevenson MD & Akehurst R (2011) Cost-effectiveness of granulocyte colony-stimulating factor prophylaxis for febrile neutropenia in patients with non-Hodgkin's lymphoma in the United Kingdom (UK) RIS download Bibtex download
  • Whyte S, Chilcott J, Essat M, Stevens J, Wong R & Kalita N (2011) Reappraisal of the options for colorectal cancer screening RIS download Bibtex download
  • Madan J, Cooper KL, Stevenson MD, Whyte S & Akehurst R (2009) Consistency between direct trial evidence and Bayesian Mixed Treatment Comparison: Is head-to-head evidence always more reliable? RIS download Bibtex download
  • Cooper KL, Madan J, Whyte S, Stevenson MD & Akehurst R (2009) Granulocyte colony-stimulating factors for prevention of febrile neutropenia following chemotherapy: systematic review and meta-analysis RIS download Bibtex download
  • Sharp L, Whyte S, Ceillachair A, Comber H, Tilson L, Usher C, Walsh C, Barry M, Tappenden P, Chilcott J & Staines A (2009) Options for a population-based colorectal cancer screening programme in Ireland: a health technology assessment RIS download Bibtex download
  • Whyte S, Chilcott J & Headley J (2008) Health economics of Colonix: A new diagnostic test in colorectal cancer RIS download Bibtex download

Posters

  • Whyte S, Dixon S, Faria R, Walker S, Sculpher M & Palmer S The value of investing in implementation activities: A case study in natriuretic peptide testing for diagnosing suspected heart failure (SMDM 15th Biennial European Meeting 8-10 June 2015). RIS download Bibtex download

Preprints

  • Mandrik O, Thomas C, Strong M & Whyte S (2021) Calibration and Validation of the Microsimulation Model in Cancer of the Bowel (MiMiC-Bowel), an Individual Patient Simulation Model for Investigation of the Cost-effectiveness of Personalised Screening and Surveillance Strategies.. RIS download Bibtex download
Research group

If you are interested in pursuing a PhD which may fit with my research areas described above please contact me regarding PhD supervision.

Teaching interests

I am module lead for the Dissertation on the MSc in Health Economics and Decision Modelling.