Totton, Nikki

Nikki Totton

BSc, MSc

Population Health, School of Medicine and Population Health

PhD Student

Ntotton1@sheffield.ac.uk

Room 1.03, The Innovation Centre

Full contact details

Nikki Totton
Population Health, School of Medicine and Population Health
Room 1.03
The Innovation Centre
217 Portobello
91ֱ��
S1 4DP

Profile

After completing a BSc in Mathematics and an MSc in Statistics and Management Science at the University of the West of England, Bristol, I began my career as a clinical trial statistician. Firstly, at Bangor University before moving over to 91ֱ��. I have a range of experience designing and analysing clinical trials as well as other study designs. I also work ad-hoc for the Research Design Service where I offer general study design advice as well as specific statistical aspects such as sample size calculations.

I started an ESRC White Rose funded doctoral fellowship with an MA in Social Research followed by the PhD project which started in October 2021.

Qualifications

BSc in Mathematics (University of the West of England)
MSc in Statistics and Management Science (University of the West of England)
MA in Social Research (University of 91ֱ��)

Research interests

PhD Title: How can benefit-risk methods be used when setting the non-inferiority margin within non-inferiority clinical trials to account for the benefit of a secondary outcome of importance?

My PhD project combines my research interests of non-inferiority clinical trials and benefit-risk assessment. Other research interests of mine are pilot and feasibility studies as well as the importance of including patients and the public within research and the difficulties surrounding this.

Current Projects:

AWARE-IBD: Putting people with inflammatory bowel disease (IBD) in control of their care.
Bracing Adolescent Idiopathic Scoliosis
BRAINS: Benefit-Risk Assessment to Inform Non-Inferiority and Superiority Study Designs
Involving patients and the public In sTatistIcal Analysis pLans.

Publications

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Featured publications

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All publications

Journal articles

Totton N, Waddingham E, Owen R, Julious S, Hughes D & Cook J (2024) . Trials, 25.
Goulão B, Morris TP, Blazeby J, Gamble C, Gillies K, Laidlaw L, Ramsay C, Soulsby I, Stewart D & Totton N (2023) . PLOS ONE, 18(12).
Bolt R, Hyslop MC, Herbert E, Papaioannou DE, Totton N, Wilson MJ, Clarkson J, Evans C, Ireland N, Kettle J , Marshman Z et al (2023) . British Journal of Anaesthesia, S0007-0912(23)00565.
Sheldon EM, Lillington G, Simpson K, Gibson K, Chambers L, D'Afflitto M, Greig N, Stearn T, Hind D, Ainley R , Winsor G et al (2022) . Health Expectations.
Bevan A, Hoo ZH, Totton N, Girling C, Davids IR, Whelan P, Antrobus S, Ainsworth J, Buchan I, Anderson A , Bourke S et al (2022) . Journal of Cystic Fibrosis.
Totton N, Bradburn M, Hoo ZH, Lewis J, Hind D, Girling C, Shepherd E, Nightingale J, Daniels T, Dewar J , Dawson S et al (2021) . Health Science Reports, 4(4).
Bevan A, Hoo ZH, Totton N, Girling C, Davids IR, Whelan P, Antrobus S, Ainsworth J, Buchan I, Anderson A , Bourke S et al (2021) . Journal of Cystic Fibrosis.
Hoo ZH, Totton N, Waterhouse S, Lewis J, Girling C, Bradburn M, Arden MA, Whelan P, Ainsworth J, Dawson S , Millward S et al (2021) . Chest.
Ali A, Tabassum D, Baig SS, Moyle B, Redgrave J, Nichols S, McGregor G, Evans K, Totton N, Cooper C & Majid A (2021) . Stroke.
Totton N, Julious S, Hughes D, Cook J, Biggs K, Coates L, Cook A, Hewitt C & Day S (2021) . Trials, 22.
Coates E, Amiel S, Baird W, Benaissa M, Brennan A, Campbell M, Chadwick P, Chater T, Choudhary P, Cooke D , Cooper C et al (2021) . BMJ Open, 11(1).
Rees CJ, Brand A, Ngu WS, Stokes C, Hoare Z, Totton N, Bhandari P, Sharp L, Bastable A, Rutter MD , Verma AM et al (2020) . Gut, 69(11), 1959-1965.
Walters SJ, Jacques RM, dos Anjos Henriques-Cadby IB, Candlish J, Totton N & Xian MTS (2019) . Trials, 20(1).
Walters SJ, Jacques RM, dos Anjos Henriques-Cadby IB, Candlish J, Totton N & Xian MTS (2019) . Trials, 20(1).
Ngu WS, Bevan R, Tsiamoulos ZP, Bassett P, Hoare Z, Rutter MD, Clifford G, Totton N, Lee TJ, Ramadas A , Silcock JG et al (2019) . Gut, 68(2), 280-288.
Roberts JL, Pritchard AW, Williams M, Totton N, Morrison V, DIn NU & Williams NH (2018) . BMJ Open, 8(8).
Ngu W, Walls M, Bhandari P, Stokes C, Totton N, Hoare Z, Bastable L & Rees C (2018) . Endoscopy International Open, 06(07), E872-E877.
Williams NH, Mawdesley K, Roberts JL, Din NU, Totton N, Charles JM, Hoare Z & Edwards RT (2018) . Pilot and Feasibility Studies, 4(1).
Morrison V, Spencer LH, Totton N, Pye K, Yeo ST, Butterworth C, Hall L, Whitaker R, Edwards RT, Timmis LJ , Hoare Z et al (2018) . International Journal of Gynecological Cancer, 28(2), 401-411.
Pye K, Totton N, Stuart N, Whitaker R, Morrison V, Edwards RT, Yeo ST, Timmis LJ, Butterworth C, Hall L , Rai T et al (2016) . Pilot and Feasibility Studies, 2(1).
Williams NH, Roberts JL, Din NU, Totton N, Charles JM, Hawkes CA, Morrison V, Hoare Z, Williams M, Pritchard AW , Alexander S et al (2016) . BMJ Open, 6(10).
Totton N, Lin J, Julious S, Chowdhury M & Brand A () . Pilot and Feasibility Studies, 9(1).
Swaby L, Perry DC, Walker K, Hind D, Mills A, Jayasuriya R, Totton N, Desoysa L, Chatters R, Young B , Sherratt F et al () . Bone & Joint Open, 4(11), 873-880.
Totton N, Julious SA, Coates E, Hughes DA, Cook JA, Biggs K, Hewitt C, Day S & Cook A () . Health Technology Assessment, 1-58.
Coates E, Wickramasekera N, Barr A, Shackley P, Lee M, Hind D, Probert C, Sebastian S, Totton N, Blackwell S , Bedford H et al () . Health Technology Assessment, 26(41), 1-118.
Williams NH, Roberts JL, Din NU, Charles JM, Totton N, Williams M, Mawdesley K, Hawkes CA, Morrison V, Lemmey A , Edwards RT et al () . Health Technology Assessment, 21(44), 1-528.

Conference proceedings papers

Coates E, Barr A, Totton N, Hind D, Shackley P, Blackwell S, Dames N, Bedford H, Lee M, Sebastian S , Probert C et al (2021) . Posters
Wildman M, Totton NV & Hoo Z (2020) NOBODY LEFT BEHIND: THE UK NATIONAL EQUITY INDICATOR USING REAL TIME DATA FROM THE CFHEALTHHUB DIGITAL LEARNING HEALTH SYSTEM TO UNDERSTAND THE REACH OF SELF-CARE SUPPORT ACROSS ADULT CENTRES. PEDIATRIC PULMONOLOGY, Vol. 55 (pp S319-S319)
Totton N, Julious S, Hughes D & Cook J (2019) . Trials, Vol. 20(Supplement 1) (pp 93-93). Brighton, UK, 6 October 2019 - 9 October 2019.
Walls M, Brand A, Ngu WS, Stokes C, Sharp L, Hoare Z, Totton N, Bastable A, Bhandari P & Rees C (2019) . Endoscopy

Posters

Hoo ZH, Totton N, Waterhouse S, Hind D, Girling C, Bradburn M, Shepherd E, Nightingale JA, Daniels TV, Dewar J , Saini G et al (2019) ePS5.05 Understanding objective adherence to preventative inhaled therapies at a centre level for quality improvement - a CFHealthHub (CFHH) improvement collaborative study.

Presentations

Preprints

Totton N, Julious S, Walters S & Coates E (2023) , Research Square Platform LLC.
Totton N, Julious S, Hughes D, Cook J, Biggs K, Coates L, Cook A, Hewitt C & Day S () .
Totton N, Julious S, Hughes D, Cook J, Biggs K, Coates L, Cook A, Hewitt C & Day S () .
Totton N, Julious S, Hughes D, Cook J, Biggs K, Coates L, Cook A, Hewitt C & Day S () .

Teaching activities

I have previous tutored on HAR6036 – Application of Statistics in the Medical and Health Sciences, HAR6045 – Further Statistics for Health Science Researchers and Critical Numbers.

I have supervised Masters projects as well as ran Research Attachment projects for the Intercalated Medical Students.

Professional activities and memberships: I am a member of the for 91ֱ��, as well as on the steering committee for the , leading the benefit-risk working group.