Bursnall, Matthew, Dr

Dr Matthew Bursnall

Population Health, School of Medicine and Population Health

Medical Statistician, Research Fellow

m.bursnall@sheffield.ac.uk
+44 114 222 0889

2028, Regent Court (ScHARR)

Full contact details

Dr Matthew Bursnall
Population Health, School of Medicine and Population Health
2028
Regent Court (ScHARR)
30 Regent Street
91ֱ��
S1 4DA

Profile: I joined the CTRU in 2018, having previously worked as a statistician in the Department for Education and as an econometrician at the National Institute for Economic and Social Research. I mainly work on the statistical design and analysis of Randomised Controlled Trials (RCTs) but am also involved in observational studies and quantitative social research. Most of my experience has been in the areas of mental health and wellbeing of adults and children, Rare diseases, Inflammatory Bowel Disease and Stem Cell therapy.

Qualifications: PhD in Statistics, University of 91ֱ�� 2001
MSc in Statistics, University of 91ֱ�� 1995
BSc in Mathematics, University of 91ֱ�� 1994

Research interests

I have an interest in the following research:

Design and analysis methods for trials for rare diseases
Sample size estimation for studies with clustering in a single arm
Assumptions for the inter-class correlation coefficient in cluster trials in the absence of previous evidence
Unbiased estimation of treatment effects in step-up trials where group-based treatment intensity is increased depending on a post-randomisation interim outcome.
Simulating trials using Causal analysis within a Target Trial Framework

Current projects

I am currently involved in the delivery of the following projects as part of the statistical team

Changing Clinical Practice for Rare Diseases Through Innovative Trial Designs

MissionEB A double blinded placebo control study of Mesenchymal Intravenous Stromal cell Infusions in children with recessive dystrophic Epidermolysis Bullosa. This is a collaboration with Great Ormond Street Hospital and the Birmingham Children’s Hospital.

The trial aims to compare the efficacy and safety profile of Autologous Haematopoietic Stem Cell Transplantation (aHSCT) vs ‘highly effective’ Disease Modifying Therapies (DMTs) – Ocrelizumab, Alemtuzumab, Cladribine and Ofatumumab. This is a collaboration with 91ֱ�� Teaching Hospitals NHS Foundation Trust.

A randomised CONtrolled trial of Tailored Acceptance and Commitment Therapy for older people with treatment resistant Generalised Anxiety Disorder. This is a collaboration with University College London.

ORION RadiO fRequency ablatION for haemorrhoids (ORION). A Pragmatic multicentre patient-/assessor-blind parallel-group individual participant randomised (1:1 allocation) randomised controlled trial. This is a collaboration with 91ֱ�� Teaching Hospitals NHS Foundation Trust.

The project is working to re-design services and deliver improved outcomes for people living with Crohn’s and Colitis.  This is a collaboration with Crohn’s and Colitis UK.

Recent projects

ESEE Steps - Enhancing Social-Emotional Health and Wellbeing in the Early Years
ISOCIALISE - Investigating SOcial Competence and Isolation in children with Autism taking part in Lego®-based therapy clubs In School Environments
PRIEST - Pre-hospital Pandemic Respiratory Infection Emergency System Triage
VTEAM - Venous Thromboembolism Assessment Model Study

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Horner D, Rex S, Reynard C, Bursnall M, Bradburn M, de Wit K, Goodacre S & Hunt BJ (2023) . BMJ Open, 13(2).
Gould RL, Thompson BJ, Rawlinson C, Kumar P, White D, Serfaty MA, Graham CD, McCracken LM, Bursnall M, Bradburn M , Young T et al (2022) . BMC Neurology, 22(1).
Bywater T, Berry V, Blower S, Bursnall M, Cox E, Mason-Jones A, McGilloway S, McKendrick K, Mitchell S, Pickett K , Richardson G et al (2022) . PLoS ONE, 17(4).
Bursnall M, Thomas B, Berntsson H, Strong E, Brayne M & Hind D (2022) . Journal of Psychosocial Rehabilitation and Mental Health.
Thomas B, Goodacre S, Lee E, Sutton L, Bursnall M, Loban A, Waterhouse S, Simmonds R, Biggs K, Marincowitz C , Schutter J et al (2021) . Emergency Medicine Journal, 38(8), 587-593.
Butcher B & Bursnall M (2013) . National Institute Economic Review, 225, F4-F14.

Conference proceedings papers

Martin RJ, Bursnall MC & Stillman EC (2001) (pp 225-239)

All publications

Journal articles

Rawlinson C, Gould RL, McDermott CJ, Thompson B, Weeks K, Gossage-Worrall R, Serfaty MA, Graham CD, McCracken L, White D , Howard RJ et al (2024) . The Cognitive Behaviour Therapist, 17.
Gould RL, McDermott CJ, Thompson BJ, Rawlinson CV, Bursnall M, Bradburn M, Kumar P, Turton EJ, White DA, Serfaty MA , Graham CD et al (2024) . The Lancet.
Keetharuth AD, Gould R, McDermott C, Thompson B, Rawlinson C, Bradburn M, Bursnall M, Kumar P, Turton E, Tappenden P , White D et al (2024) . European Journal of Neurology.
Brittain G, Petrie J, Duffy KEM, Glover R, Hullock K, Papaioannou D, Roldan E, Beecher C, Bursnall M, Ciccarelli O , Coles AJ et al (2024) . BMJ Open, 14(2), e083582-e083582.
Gould RL, Rawlinson C, Thompson B, Weeks K, Gossage-Worrall R, Cantrill H, Serfaty MA, Graham CD, McCracken LM, White D , Howard RJ et al (2023) . Pilot and Feasibility Studies, 9.
Sheldon EM, Bursnall M, Hawkins R, Roman SC, Randall K, Winsor G, WAKEMAN R, Hind D & Lobo AJ (2023) . Gastroenterology, 164(6), S-679.
Wright B, Kingsley E, Cooper C, Biggs K, Bursnall M, Wang H-I, Chater T, Coates E, Teare MD, McKendrick K , Gomez de la Cuesta G et al (2023) . Autism.
Horner D, Rex S, Reynard C, Bursnall M, Bradburn M, de Wit K, Goodacre S & Hunt BJ (2023) . BMJ Open, 13(2).
Sheldon E, Roman S, Bursnall M, Hawkins R, Lobo A, Hind D, Randall K, Wakeman R & Ainley R (2023) . Journal of Crohn's and Colitis, 17(Supplement_1), i431-i432.
Gould RL, Thompson BJ, Rawlinson C, Kumar P, White D, Serfaty MA, Graham CD, McCracken LM, Bursnall M, Bradburn M , Young T et al (2022) . BMC Neurology, 22(1).
Girling C, Lee MJ, Vimalchandran D, Jayne DJ, Stancliffe S, Wailoo A, Bradburn M, Hind D, Bursnall M, Robinson LK & Brown SR (2022) . Techniques in Coloproctology.
Bywater T, Berry V, Blower S, Bursnall M, Cox E, Mason-Jones A, McGilloway S, McKendrick K, Mitchell S, Pickett K , Richardson G et al (2022) . PLoS ONE, 17(4).
Anders J, Foliano F, Bursnall M, Dorsett R, Hudson N, Runge J & Speckesser S (2022) . Journal of Research on Educational Effectiveness.
Bursnall M, Thomas B, Berntsson H, Strong E, Brayne M & Hind D (2022) . Journal of Psychosocial Rehabilitation and Mental Health.
Wang H-I, Wright BD, Bursnall M, Cooper C, Kingsley E, Le Couteur A, Teare D, Biggs K, McKendrick K, de la Cuesta GG , Chater T et al (2022) . BMJ Open, 12(1).
Blower SL, Berry VL, Bursnall MC, Cohen J, Gridley N, Loban A, Mandefield L, Mason-Jones AJ, McGilloway S, McKendrick KL , Mitchell SB et al (2021) . Journal of Child and Family Studies, 30(8), 1933-1949.
Thomas B, Goodacre S, Lee E, Sutton L, Bursnall M, Loban A, Waterhouse S, Simmonds R, Biggs K, Marincowitz C , Schutter J et al (2021) . Emergency Medicine Journal, 38(8), 587-593.
Wyld L, Reed MWR, Collins K, Burton M, Lifford K, Edwards A, Ward S, Holmes G, Morgan J, Bradburn M , Walters SJ et al (2021) . British Journal of Surgery, 108(5), 499-510.
Stevens R, Bursnall M, Chadwick C, Davies H, Flowers M, Blundell C & Davies M (2020) . Foot and Ankle International, 41(1), 31-36.
Butcher B & Bursnall M (2013) . National Institute Economic Review, 225, F4-F14.
MARTIN RJ, BURSNALL MC & STILLMAN EC (1999) . Statistics and Computing, 9(3), 229-237.
Horner DE, Davis S, Pandor A, Shulver H, Goodacre S, Hind D, Rex S, Gillett M, Bursnall M, Griffin X , Holland M et al () . Health Technology Assessment, 1-166.
Kingsley E, Biggs K, Solaiman K, Packham A, Nekooi R, Bursnall M, McKendrick K, Cooper CL & Wright B () . Research Methods in Medicine & Health Sciences.
Wright B, Kingsley E, Cooper C, Biggs K, Bursnall M, Wang H-I, Chater T, Coates E, Teare MD, McKendrick K , Gomez de la Cuesta G et al () . Public Health Research, 1-137.
Bywater T, Berry V, Blower S, Bursnall M, Cox E, Mason-Jones A, McGilloway S, McKendrick K, Mitchell S, Pickett K , Richardson G et al () . Public Health Research, 10(8), 1-162.

Conference proceedings papers

Ezaydi N, McCormick S, Bursnall M, Sheldon E, Ainley R, Hind D & Lobo A (2024) . Poster Presentations
Totton N, Sheldon E, Ezaydi N, Bursnall M, Hind D, Wakeman R & Lobo A (2024) . Journal of Crohn's and Colitis, Vol. 18(Supplement 1) (pp I837-I837). Stockholm, Sweden, 21 February 2024 - 21 February 2024.
Sheldon E, Bursnall M, Ainley R, Roman S, Randall K, Hind D & Lobo A (2023) . Poster presentations
Martin RJ, Bursnall MC & Stillman EC (2001) (pp 225-239)

Website content

Bursnall MC SAP changing mindsets EEF.
Bursnall M Embedding Formative Assessment SAP.

Scholarly editions

Bursnall M, Nafilyan V & Speckesser S An analysis of the duration and achievement of apprenticeships in England.

Preprints

Goodacre S, Thomas B, Sutton L, Bursnall M, Lee E, Bradburn M, Loban A, Waterhouse S, Simmonds R, Biggs K , Marincowitz C et al (2020) , Cold Spring Harbor Laboratory.
Biggs K, Thomas B, Goodacre S, Lee E, Sutton L, Bursnall M, Loban A, Waterhouse S, Simmonds R, Marincowitz C , Schutter J et al () , Cold Spring Harbor Laboratory.

Professional activities and memberships

I am the independent statistician on the Data Monitoring Committee or Trial Steering Committees for three trials:

TBI Sertraline - A multi-centre, placebo-controlled, double-blind, randomised controlled trial of the clinical and cost-effectiveness of sertraline in preventing depression in adults following a traumatic brain injury.
iACT4CARERS –A randomised controlled trial of the clinical and cost effectiveness of internet-delivered self-help Acceptance and Commitment Therapy for family carers of people with dementia.
PROSPECT - A multi-centre, two-arm Phase III single-blind randomised controlled trial (RCT) of the clinical cost-effectiveness of targeted psychological therapy for suicidal male prisoners by enhancing access to therapies.