Dr Daniel Blackburn
BSc, MBChB, MRCP, PhD
Neuroscience, School of Medicine and Population Health
Senior Lecturer
Honorary Consultant Neurologist
+44 114 215 9101
Full contact details
Neuroscience, School of Medicine and Population Health
91直播 Institute for Translational Neuroscience (SITraN)
385a Glossop Road
91直播
S10 2HQ
- Profile
-
I completed my undergraduate medical degree in Liverpool in 1998 and did my medical training in London. I have worked as a neurology SpR in Singapore and Nottingham prior to joining the University of 91直播 as a PhD student in 2005.
I worked as a clinical lecturer in Neurology from 2010-2013.I have been a senior lecturer since 2018. My main subspecialty interest is in dementia.
- Research interests
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My research interests are into developing non-invasive scalable diagnostic tests for early dementia or cognitive impairment. I am investigating novel mechanisms of diagnosis of Alzheimer鈥檚 disease, post-stroke dementia and other dementias using automated assessment of language & electroencephalography (EEG).
I co-lead the development of CognoSpeakTM () with Heidi Christensen from UoS Department of Computer Science (/dcs). This is an automated assessment of Cognition that can be undertaken in people鈥檚 own homes. We have several on-going grants to develop this for use in Memory Assessment Pathways (MAP) and in the post-stroke population
I am working on novel resting state EEG processing approach to detect cognitive impairment.
I am investigating the utility of telematics to assess driving safety.
I also have a research interest in the role of astrocytes in neurodegeneration. My PhD investigated this in MND and I am part of a team investigating an in-vitro model of sporadic AD using inducible Neural Precursor Technology to grow astrocytes and neurones from people with sporadic AD and assay metabolic markers.
Current Projects
PI: University of 91直播, Participatory Research. Feb-July 2023. Co-evaluation of partnership working to develop AI dementia detection health technology. 拢14,030
PI:INIHR i4i grant. CognoSpeak: a Cognitive Health Assessment Tool (CcHAT). 拢1.47惭. 36 months. Start date 01.02.2022
COEN6011: Investigating neuronal hyperactivity as a link between amyloid-尾 and tau spreading in Alzheimer鈥檚 disease (NeurActAmy) Submitted Dec 2022- Successful
KE Funding application, 拢22,904 of EPSRC funding awarded to support project: 鈥Establishing medical device regulatory appropriate software development at TUoS: Establish and trial an eQMS solution for CognoSpeak (CognoSpeak-eQMS)鈥. Dec 2022-June 2023.
Alzheimer Research UK Local Network grant, Investigating Barriers to Accessing Memory Pathways for people from South Asian background and exploring acceptability of CognoSpeak (automated cognitive assessment tool). Hina Khan, Dr Gregor Russell and Iftikhar Khan (Bradford District Care NHS Foundation Trust) & Dr Daniel Blackburn 拢5000. March 2023- Feb 2024
NIHR HSDR: Improving triadic decision making involving people with dementia. Led by Traci Walker (co-applicants Markus Reuber, Simon Bell, Alistair Wardrope). Start date 01.10.2022- 30.09.202. 拢525,092.89.
NIHR Three Schools: Dementia Research Programme. Improving the lives of people living with dementia and carers 2021-2024. Dementia Career Development Awards: Establishing a dementia related research career and writing a research funding proposal focused on developing a complex intervention to support the wellbeing of people with mild cognitive impairment, using a public health approach. Start date 01.06.2022- 31.06.2023; 拢36,145
Equal, diverse and inclusive primary care research delivery (EDI-PCR delivery). Jon Dickson, Professor Liddy Goyder, Professor Adewale Adebajo MBE, Jodie Keyworth, Dr Dan Blackburn, Steve Knight, Professor Simon Heller, Dr Dipak Patel, Professor Chris Newman, Karen French, Ian Baxter. Start date March 2022- End date July 2022. 拢30碍
UKRI ISCF Healthy Ageing Catalyst Award 2020; Understanding elderly drivers' behaviour and fitness to drive. 拢62,500
Rosetrees Charity INTERDISCIPLINARY PRIZE 2019
MEDICINE WITH MATHEMATICS / COMPUTING / ARTIFICIAL INTELLIGENCE COMPutational Assessment of Stroke Survivors (COMPASS) 拢250,000 (co-funded with Knowledge Exchange,(UoS), Clinical Research Network Yorkshire & Humber,Health & Care Partnership, 91直播. Remote monitoring people with Mild Cognitive Impairment using combined technology of the Digital Doctor and ViVA 拢24,774 2019-2021.
Health Education England/NIHR Integrated Clinical Academic Programme Internship Scheme 2019/20. 拢8000. Zoe Unwin, EEG physiologist.
Global Challenge Research Fund (GCRF) Pump Priming Award Notification (拢7,000), 2018. Investigating potential of QEEG and digital doctor in memory assessment pathways in Kenya
Medical Research Council Confidence in Concept. COCOA (COmputerised Cognitive Assessment) 鈥 proof-of-concept. 2018-19. 拢49,513
4wardNorth Wellcome Academy PhD Training Fellowship to fund Dr Simon Bell鈥檚 PhD project- Characterising astrocyte metabolic deficits in sporadic and familial AD to identify new therapeutic targets. 2018-2020.
Neuroscience Research fund- Ryder Briggs (拢32,000) March 2017-19. Developing qEEG as biomarker in fronto-temporal dementia.
ARUK: ARUK-PPG2018A-009: Neutrophil derived microvesicles: linking systemic inflammation and dementia. PI Julie Simpson. 2018-19.
Neuroscience small grant from 91直播 teaching Hospital鈥檚- to fund Academic Clinical Fellow Ronan O鈥橫alley develop the Avatar project to analyse semantic and letter fluency using Automatic Speech Recognition- 2018. (拢3200)
Alzheimer research UK Preparatory Clinical Research Fellowship (ARUK-PCRF2016A-1: 拢69998- Jan 2016). Creating an Astrocyte model of Alzheimer鈥檚 disease using induced Neural Progenitor Cell Technology PI is Simon Bell who is my academic clinical fellow I am supervising. Collaboration with Professor Stephen Wharton, Drs Laura Ferraiuolo and Heather Mortiboys.
NIHR Health Technology Assessment Programme. 14/140/80 Journeying through dementia; randomised controlled trial of clinical and cost effectiveness. 2015-2019. (拢2,017,925). Collaboration with ScHARR and 91直播 Health and Social Care Trust
NIHR Research Design Service Yorkshire and Humber (RDS YH) public involvement in grant application to develop Public and patient acceptability and co-design input on the Avatar project (拢480) 2018.
Medical Research Council Proximity to Discovery (MRC P2D: 拢4,988). Development of a novel biomarker for dementia diagnosis based on quantitative electroencephalography (qEEG). 2015-2016. Collaboration between neurophysiology and a commercial partner the BlackBox Toolkit company
Alzheimer鈥檚 Research United Kingdom (ARUK-PPG20114B-25) 2014-2016 (拢29,805). Plus Yorkshire branch of the Alzheimer鈥檚 Research Trust Network. 2015 (拢4000). Both ARUK grants are for 鈥楧eveloping a new biomarker for the early diagnosis of dementia; a novel non-linear signal processing approach using resting state EEG鈥
NIHR Research for Patient Benefit (RfPB) Programme: PB-PG-0211-24079 鈥 Using Conversation Analysis in the Differential Diagnosis of Memory Problems: a pilot study. 2013-2015. (拢230,000).
- Publications
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Journal articles
- . Research on Language and Social Interaction, 57(4), 399-416.
- . The American Journal of Human Genetics.
- . Language and Health.
- . Computers in Biology and Medicine, 168, 107701-107701.
- . Alzheimer's & Dementia, 19(S14).
- . Alzheimer's & Dementia, 19(S20).
- . Alzheimer's & Dementia, 19(S13).
- . Journal of Interactional Research in Communication Disorders, 14(3), 408-429.
- . IEEE Trans Neural Syst Rehabil Eng, PP.
- . Clinical Linguistics & Phonetics.
- . Alzheimer's & Dementia, 19(S4).
- . Neuroscience.
- . Neuroscience, 521, 77-88.
- . Nature Medicine, 1-11.
- . IEEE Transactions on Neural Systems and Rehabilitation Engineering, 30, 2651-2660.
- . Journal of Neurology, Neurosurgery & Psychiatry, 93(9), e2.246-e2.246.
- . Journal of Neural Engineering, 19(4), 046034-046034.
- . Journal of Medical Engineering & Technology.
- . Frontiers in Psychiatry, 13.
- . Alzheimer's & Dementia, 17(S7).
- . Alzheimer's & Dementia, 17(S5).
- Study protocol: SOcial LImitations Turn Up DEmentia (SOLITUDE)鈥擨mpact of COVID鈥19 social isolation on patients鈥 cognition and mental health and on carers鈥 wellbeing. Alzheimer's & dementia : the journal of the Alzheimer's Association, 17(Suppl 7).
- . IEEE Journal of Biomedical and Health Informatics.
- . Brain.
- . Frontiers in Aging Neuroscience, 13.
- . Practical Neurology, 21(4), 351-353.
- How can automated linguistic analysis help to discern functional cognitive disorder from healthy controls and mild cognitive impairment?. BJPsych open, 7(Suppl 1), S7-S7.
- . BJPsych Open, 7(S1), S7-S7.
- . Biomedical Signal Processing and Control, 67.
- . Biomedicines, 9(1).
- . Patient Education and Counseling.
- . Journal of Neurology, Neurosurgery & Psychiatry, 92(1), 12-15.
- . Alzheimer's & Dementia, 16(S4).
- . Alzheimer's & Dementia, 16(S6).
- . Alzheimer's & Dementia, 16(S6).
- . Current Alzheimer Research, 17.
- . Neurology, 95(24), e3288-e3302.
- . Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration.
- . Brain.
- . Journal of Neurology, Neurosurgery & Psychiatry, 91(8), e18.2-e19.
- . Clinical Linguistics & Phonetics.
- . Neurological Sciences.
- . The Lancet Psychiatry, 7(6), 491-505.
- . Journal of Personalized Medicine, 10(2).
- . Neurology, 94(15_supplement).
- . Neurology, 94(15_supplement).
- . Journal of Neurology Neurosurgery & Psychiatry, 90(12), a21.
- . Journal of Neurology Neurosurgery & Psychiatry, 90(12), a2.
- . Cerebellum & Ataxias, 6(5).
- . Journal of Neurology Neurosurgery & Psychiatry, 90(12).
- . Journal of Neurology Neurosurgery & Psychiatry, 90(12).
- . IEEE Transactions on Medical Imaging.
- . Epilepsia, 60(11), 2182-2193.
- . Cortex, 119, 100-110.
- . Postgraduate Medicine, 131(7), 546-549.
- . PLoS ONE, 14(5).
- . IEEE Transactions on Neural Systems and Rehabilitation Engineering.
- . Neuromodulation: Technology at the Neural Interface.
- . Computer Speech and Language, 53, 65-79.
- . Journal of Molecular Biology, 430(21), 3942-3953.
- . Journal of Music Therapy, 55(4), 439-462.
- . Dementia.
- . Sociology of Health and Illness.
- . Brain Sciences, 8(7), 134-134.
- . Physics in Medicine and Biology, 63(14), 14nt01-14nt01.
- . Alzheimer Disease and Associated Disorders, 32(3), 197-206.
- . Clinical Neurophysiology, 129(7), 1372-1373.
- . British Journal of General Practice, 68(667), e123-e138.
- . Alzheimer's & Dementia, 14(3), 280-292.
- . Journal of Neurology, Neurosurgery & Psychiatry, 88(Suppl 1), A19.4-A20.
- . Journal of Neurology, Neurosurgery & Psychiatry, 88(Suppl 1), A17.1-A17.
- . Acta Neuropsychiatrica.
- . Alzheimer's & Dementia, 13(7S_Part_26), P1269-P1269.
- . Alzheimer's & Dementia, 13(7S_Part_21), P1042-P1043.
- . Journal of Alzheimer's Disease, 58(2), 373-387.
- . Psychogeriatrics.
- . PLOS ONE, 12(1).
- . Alzheimer's & Dementia, 13(6), 624-633.
- . Psychogeriatrics, 17(2), 146-146.
- . Alzheimer's & Dementia, 12, P753-P754.
- . Alzheimer's & Dementia, 12, P691-P691.
- Papillary Thyroid Cancer in Subjects Who Were Children at the time of the Chernobyl Nuclear Accident: Some Lessons for The Management of Fukushima鈥檚 Aftermaths. Jacobs Journal of Radiation Oncology, 3(2).
- . Practical Neurology, 16(2), 153-156.
- . Aging and Mental Health, 20(5), 500-509.
- . Pilot and Feasibility Studies, 1.
- . FRONTIERS IN CELLULAR NEUROSCIENCE, 9.
- . Journal of Alzheimer's Disease, 48(s1), S5-S17.
- . Patient Education and Counseling, 98(9), 1071-1077.
- . Practical Neurology, 15(2), 124-126.
- . Age and Ageing, 44(2), 344-345.
- . Trials, 16.
- . Age and Ageing, 43(eLetters Supplement).
- . British Medical Bulletin, 112(1), 71-81.
- . Alzheimer's & Dementia, 10, P721-P721.
- . Trials, 14.
- . Alzheimer's & Dementia, 9, P493-P493.
- . Alzheimer's & Dementia, 9, P526-P526.
- . Practical Neurology, 13(2), 114-119.
- . Practical Neurology, 13(3), 193-195.
- . Practical Neurology, 13(4), 263-267.
- Repeat cognitive screening (MoCA, MMSE & ACE-R, IQCODE) in a high risk post-stroke population: data from the 'Prevention Of Decline in Cognition After Stroke Trial' (POD-CAST). CEREBROVASCULAR DISEASES, 35, 519-519.
- . Journal of Neurology, 260(3), 914-916.
- . Age and Ageing, 42(1), 113-116.
- . The Spine Journal, 12(7), 629-630.
- . BMC Neuroscience, 12(1).
- . Stroke, 42(11).
- . Journal of Neurology, Neurosurgery & Psychiatry, 82(9), e4-e4.
- . Journal of Neurology, Neurosurgery & Psychiatry, 82(9), e4-e4.
- . NeuroReport, 20(16), 1450-1455.
- . APMIS, 117(10), 768-772.
- . Glia, 57(12), 1251-1264.
- . Practical Neurology, 7(5), 282-284.
- . The Journal of Spinal Cord Medicine, 1-7.
- . Molecular Psychiatry.
- . Frontiers in Dementia, 2, 1207546.
- . Nature Medicine.
- . The Cerebellum.
- . Journal of Medical Ethics.
- . International Journal of Molecular Sciences, 23(11), 5913-5913.
- . Acta Neuropsychiatrica, 1-19.
- . International Journal of Geriatric Psychiatry.
- .
- . Journal of Alzheimer's Disease Reports, 1-13.
- . International Journal of Molecular Sciences, 21(23), 8924-8924.
- . International Journal of Clinical Practice.
- . Journal of Neurology, Neurosurgery & Psychiatry.
- . Journal of Neurology.
- .
- . PLOS ONE, 10(9), e0134574-e0134574.
- . Journal of Neurology, Neurosurgery & Psychiatry, 77(3), 420-421.
- Patients who are not driving 6 weeks after TIA have higher levels of anxiety. Psychogeriatrics..
Conference proceedings papers
- . 2023 IEEE Automatic Speech Recognition and Understanding Workshop (ASRU), 16 December 2023 - 20 December 2023.
- . 2023 IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2 December 2023 - 2 December 2023.
- (pp 263-274)
- . 2023 IEEE 17th International Conference on Automatic Face and Gesture Recognition (FG), 5 January 2023 - 8 January 2023.
- . 2022 IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 3 December 2022 - 3 December 2022.
- . 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 11 July 2022 - 15 July 2022.
- . ICASSP 2021 - 2021 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 6 June 2021 - 11 June 2021.
- . Lecture Notes in Networks and Systems, Vol. 285 (pp 58-69)
- . 2021 9th International Conference on Affective Computing and Intelligent Interaction, ACII 2021
- . ICASSP 2019 - 2019 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 12 May 2019 - 17 May 2019.
- . Journal of the Neurological Sciences, Vol. 381 (pp 319-319)
- . Journal of the Neurological Sciences, Vol. 381 (pp 319-319)
- . Interspeech 2017 (pp 3147-3151)
- . Alzheimer's & Dementia, Vol. 13(7) (pp P1238-P1238), 15 July 2017 - 20 July 2017.
- . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 87(12) (pp e1.192-e1)
- . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 87(12) (pp e1.191-e1)
- . Proceedings of Interspeech 2016 (pp 1220-1224)
- . Alzheimer's & Dementia, Vol. 12 (pp P353-P354)
- . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.162-e4)
- . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.137-e4)
- . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.171-e4)
- . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 83(Suppl 2) (pp A16.2-A16)
- . Interspeech 2022
- . Interspeech 2022
- . Interspeech 2021
- . Interspeech 2021
- . Interspeech 2020
- . Interspeech 2020
- . Interspeech 2020
- . Interspeech 2020
- . Interspeech 2019
- . Interspeech 2018
Preprints
- , arXiv.
- , Cold Spring Harbor Laboratory.
- Bispectrum-based Cross-frequency Functional Connectivity: Classification of Alzheimer's disease, arXiv.
- Characterising Alzheimer's Disease with EEG-based Energy Landscape Analysis, arXiv.
- , Authorea.
- Data augmentation using generative networks to identify dementia, arXiv.
- Detecting Alzheimer's Disease by estimating attention and elicitation path through the alignment of spoken picture descriptions with the picture prompt.
- Detecting Alzheimer's Disease by estimating attention and elicitation path through the alignment of spoken picture descriptions with the picture prompt, arXiv.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- Research group
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I co-supervise the following students
1st Supervisor PhD
- Dr Ronan O鈥橫alley is working on the digital doctor project to explore how linguistic analysis of semantic dysfunction can be combined with imaging and AD biomarkers to best manage MCI and predict conversion to AD.
- Dr Leslie Ing: Developing CognoMND and automated assessment of Cognition based on language for people with MND (Y2). Co-supervisor Prof Chris McDermott and Prof Heidi Christensen
- Labhpreet Kaur investigating automated assessment of collateral history form acre-partners to aid detection and diagnosis of cognitive impairment (Y1) Co-supervisor Prof Heidi Christensen
2nd Supervisor PhD
- Sam Hollands 鈥淓arly onset cognitive impairment detection from speech and language signals鈥 1st supervise Heidi Christensen Funding Computer Science Doctoral Training Centre
- Meg Thomas- Roe of dysfuencies in cognitive impairment. 1st Supervisor Traci Walker. Computer Science Doctoral Training Centre
- Jin Ni- Individualised Adaptive P300-based Brain-computer Interface for TreatincCognitive Impairment Symptoms after Stroke. 1st supervisor Mahnaz Arvanah
- Mian Kou is the student's name.: Multimodal Intelligent Neural Interfaces for Early Detection and Treatment of Post-stroke Dementia. 1st supervisor Mahnaz Arvanah. Funding DiMEM.
Academic Clinical Lecturers
- Dr Simon Bell 鈥 has been funded by ARUK, NIHR 91直播 BRC and now Wellcome 4ward north Academy investigating models of sporadic AD using i-astrocytes created using INPC
- Dr Richard Bevan Jones. -investigating FTD and cognitive and behavioural disturbance in atypical Parkinsons鈥檚 disease.
Clinical Fellow
Dr Hina Khan, Investigating feasibility of cognitive assessment using CognoSpeak in South Asian communities
- Teaching interests
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I helped set up the Clinical Neurology MSc course. I was the course lead for 12 months and have led two modules . I provide lectures and supervise research projects and CNELM students.
I teach on Neurodegeneration to MSc, UG medical students and PG students
I am a faculty member of the Neurology Academy, (The Edge, 91直播) which provides masterclass teaching on Dementia for clinicians
- Professional activities and memberships
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- Chair of the Special Interest Group in Cognitive Disorders 鈥 Association of British Neurologists
- ARUK Clinical Policy Advisory Panel member
- I am co-lead for dementia, for the Yorkshire and Humber regional Clincial Research Network.
- Member of the South Yorkshire Interest Group in Dementia
- Member of UoS Senate Research and Innovation Committee
- I sit on the Dementia Translational Research Collaboration panel
- I am the lead for long term neurological conditions for Devices for Dignity NIHR MTC.
- Collaborators
- Professor Robert Perneckzy, Psychaity, UoS
- Professor Heidi Christensen- Professor of Spoken Language Technology, Computer Science, UoS
- Professor Markus Reuber- Neurology UoS
- Professor Oliver Bandmann, Professor of Movement disorders, UoS
- Dr Traci Walker- Lecturer Department of Human Communication Sciences, Uo
- Professor Chris McDermott, Professor of Translational Neurology
- Dr Mahnaz Arvaneh, Senior Lecturer, Department of Automatic Control and Systems Engineering
- Dr Jon Dickson, Academic GP, UoS
- Dr Sam Creaven, Academic GP, University of Bristol
- Dr Ptolemaios Sarrigiannis, Consultant Neurophysiologist
- Professor Ananlena Venneri- Neuropsychology & Imaging, Brunel University
- Dr Matteo De Marco- Neuropsychology & Imaging, Brunel University
- Professor Vanessa Raymond, University of Oxford
- Professor Paresh Malhotra, Imperial College London