Professor Steven Sourbron
Clinical Medicine, School of Medicine and Population Health
Professor in Medical Imaging Physics
+44 114 215 9155
Full contact details
Clinical Medicine, School of Medicine and Population Health
Polaris
18 Claremont Crescent
91直播
S10 2TA
- Profile
-
For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
I am a medical physicist with expertise in quantitative Magnetic Resonance Imaging (MRI). Since November 2019, I am Professor in Medical Imaging in the University of 91直播. Prior to that I was Lecturer in Magnetic Resonance Imaging in the University of Leeds (2010-2019) and post-doctoral researcher in the Radiology department of the Ludwig-Maximilian University Munich (2005-2010). I obtained a PhD in the radiology department of the Vrije Universiteit Brussel in 2005, and Bachelor and Master degree also at the Vrije Universiteit Brussel in 1999.
- Research interests
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My main research interest is in the development of quantitative imaging biomarkers (QIBs) and applications thereof in clinical studies, drug development and basic research. QIBs are measurements extracted from medical images that can be used as indicators of normal biological processes, disease progression or treatment response. Unlike other sources of biomarkers such as biological fluids (blood, urine, 鈥), QIBs can track these processes in-vivo and in-situ, which can significantly impact on future clinical practice.
QIB development in MRI is a highly interdisciplinary area and sits on the interface between (bio)physics, engineering, computation, biology and medicine. An example of current work is the development and validation of QIBs that measure liver function, and using these to identify patients that are likely to suffer from toxic side effects of drugs . Another application is in predicting which patients can tolerate surgery for liver cancer, which may in future allow us to offer this life-saving treatment to more patients (HEPARIM project).
We are also very active in Chronic Kidney Disease, where we are looking at larger panels of QIBs to identify patients that are at risk of progression and therefore are in need of more aggressive management . Beyond liver and kidney, we are working on other application areas such as predicting outcomes of mechanical thrombectomy in acute stroke, studying mechanisms neurodegenerative disease progression in the spinal cord, or evaluating the effect of cancer treatment on the heart. QIBs promise to become essential tools in future medical practice just as blood- and urine tests today.
Realising this potential however is an enormous undertaking that requires a highly interdisciplinary and coordinated approach to research. I am therefore increasingly active in national and international networks aiming to improve reproducibility of research and societal impact. An example is the EU-wide networking project , the open-source project , and the UK-wide partnership project of the UK Renal Imaging Network (UKRIN-MAPS).
91直播 medical imaging research strands:
- Abdominal imaging (lead)
- Imaging biomarkers (lead)
- Cardiovascular imaging (member)
Current projects:
- 10/2020 - 10/2024. . NIHR - Efficacy and Mechanism Evaluation Programme. Role: CoI and lead of the central image processing facility.
- 09/2020-09/2027. PET-MRI of the spinal cord for translational neuroscience applications. Medical Research Council 鈥 General Electric iCASE studentship. DiMeN Doctoral Training Programme. Role: Lead supervisor.
- 09/2019 鈥 09/2022. . EPSRC-CASE PhD studentship co-funded by Bayer AG. Role: supervisor.
- 09/2018 鈥 09/2021. , Medical Research Council, Partnership Grant. Role: CoI and lead of the work package on image processing and quality assurance.
- 01/2018 - 01/2021. (HEPARIM study), Medical Research Council. Role: PI
- 04/2017 鈥 04/2021. .COST 鈥 European Cooperation in Science and Technology. Role: Primary proposer and chair.
- 01/2017 - 01/2022. . Innovative Medicines Initiative. Role: lead of clinical MRI development.
- 09/2016 鈥 09/2021. . Medicines Initiative. Role: work package lead.
- 01/2019 鈥 01/2022. Targeting 尾-cell failure in lean patients with type 2 diabetes; Diabetes UK, CoI (Eylem Levelt, Sven Plein, Steven Sourbron, Ramzi Ajjan, Mark Kearney, Richard Cubbon). Role: CoI.
- 06/2017 鈥 06/2020. ; EPSRC. Role: CoI.
- 01/2017 鈥 01/2021. ,FRINATEK 鈥 Norwegian Research Council. Role: CoI.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 131-140.
- . Alzheimer's & Dementia, 15(6), 840-858.
- . Nephrology Dialysis Transplantation, 33(Sup 2), ii4-ii14.
- .
Chapters
All publications
Journal articles
- . Journal of the American Society of Nephrology, 35(10S).
- . Nephrology Dialysis Transplantation, 39(Supplement_1).
- . Journal of the American Society of Nephrology, 34(11S), 852-852.
- . Magnetic Resonance in Medicine.
- . Magnetic Resonance in Medicine.
- . Nephrology Dialysis Transplantation, 38(Supplement_1).
- . iScience, 26(5), 106686-106686.
- . Pharmaceutics, 15(3).
- . Circulation, 146(4), 364-367.
- . Journal of Magnetic Resonance Imaging.
- . BMC Cancer, 21(1).
- . Journal of the American Society of Nephrology, 32(10S), b12-b12.
- . EJNMMI Physics, 8.
- . Methods in molecular biology (Clifton, N.J.), 2216, 3-23.
- . NMR in Biomedicine, 34(1).
- . Insights into Imaging, 11(1).
- . Journal of Magnetic Resonance Imaging.
- . BMC Nephrology, 21(1).
- . Nephrology Dialysis Transplantation, 35(6), 915-919.
- . Quantitative Imaging in Medicine and Surgery, 10(6), 1298-1306.
- . 101. Deutscher R枚ntgenkongress und 9. Gemeinsamer Kongress der DRG und 脰RG.
- . Journal of the American College of Cardiology, 75(11), 1672-1672.
- . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 131-140.
- . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 177-195.
- . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 1-2.
- . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 141-161.
- . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 199-215.
- . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 163-176.
- . Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 197-198.
- . Insights into Imaging, 10(1).
- . Drug Metabolism and Pharmacokinetics, 35(1), S96-S96.
- . IEEE Transactions on Radiation and Plasma Medical Sciences, 4(4), 422-432.
- . Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11, 191-204.
- . European Journal of Radiology, 117, 209-215.
- . Alzheimer's & Dementia, 15(6), 840-858.
- . Magnetic Resonance Imaging, 59, 121-129.
- . Magnetic Resonance Imaging, 59, 53-60.
- . Nephrology Dialysis Transplantation, 33(Sup 2), ii4-ii14.
- . Journal of the Belgian Society of Radiology, 102(1).
- . Magnetic Resonance in Medicine, 77(6), 2414-2423.
- . Acta Radiologica, 58(6), 748-757.
- . Journal of Magnetic Resonance Imaging, 45(4), 1177-1185.
- . Investigative Radiology, 52(3), 135-141.
- . Magnetic Resonance in Medicine, 76(3), 998-1006.
- . Journal of Cardiovascular Magnetic Resonance, 18(1).
- . HPB, 18, e697-e697.
- . Journal of Magnetic Resonance Imaging, 43(3), 566-573.
- . BMC Medical Imaging, 16(1).
- . Heart, 101(Suppl 4), A78-A79.
- . Heart, 101(Suppl 4), A48.2-A49.
- . Radiology, 275(2), 393-402.
- . BMC Cancer, 15(1).
- . Journal of Cardiovascular Magnetic Resonance, 17(1), 4-4.
- . Journal of Computer Assisted Tomography, 39(5), 643-648.
- . Investigative Radiology, 50(9), 584-593.
- . Magnetic Resonance in Medicine, 73(1), 244-253.
- . Heart, 100(Suppl 3), A60.3-A61.
- . Journal of Cardiovascular Magnetic Resonance, 16(1), 19-19.
- . IEEE Transactions on Medical Imaging, 33(4), 935-946.
- . Journal of Cardiovascular Magnetic Resonance, 16(S1).
- . Journal of Cardiovascular Magnetic Resonance, 16(S1).
- . Journal of Cardiovascular Magnetic Resonance, 16(S1).
- . Journal of Cardiovascular Magnetic Resonance, 16(S1).
- . Journal of Cardiovascular Magnetic Resonance, 16(S1).
- . Investigative Radiology, 49(1), 7-14.
- . European Radiology, 24(1), 112-119.
- . Journal of Magnetic Resonance Imaging, 40(2), 457-466.
- . Magnetic Resonance in Medicine, 72(3), 902-902.
- . Journal of Magnetic Resonance Imaging, 38(6), 1554-1563.
- . Magnetic Resonance in Medicine, 70(6), 1591-1597.
- . The International Journal of Cardiovascular Imaging, 29(7), 1527-1536.
- . American Journal of Physiology-Renal Physiology, 305(5), F672-F678.
- . Clinical Radiology, 68(9), 887-894.
- . NMR in Biomedicine, 26(8), 1004-1027.
- . American Journal of Roentgenology, 200(6), W635-W643.
- . Journal of Pharmacokinetics and Pharmacodynamics, 40(3), 281-300.
- . Academic Radiology, 20(6), 685-693.
- . Heart, 99(suppl 2), A55-A56.
- . Heart, 99(suppl 2), A56.2-A57.
- . Journal of Magnetic Resonance Imaging, 37(5), 1109-1114.
- . Magnetic Resonance in Medicine, 69(5), 1430-1437.
- . Investigative Radiology, 48(2), 92-97.
- Regional variation in myocardial blood flow in patients with left bundle branch block evaluated with quantitative perfusion CMR. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 15(Suppl 1), P205-P205.
- Associated factors for a false negative cardiovascular magnetic resonance perfusion study: a CE-MARC substudy. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 15(Suppl 1), P214-P214.
- Quantitative whole-heart three-dimensional magnetic resonance myocardial perfusion imaging in systole and diastole at 3.0T. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 15(Suppl 1), P206-P206.
- . Journal of Cardiovascular Magnetic Resonance, 15(S1).
- . Journal of Cardiovascular Magnetic Resonance, 15(S1).
- . Journal of Digital Imaging, 26(2), 344-352.
- . Journal of Cardiovascular Magnetic Resonance, 15(Suppl 1), P195-P195.
- . Journal of Cardiovascular Magnetic Resonance, 15(S1).
- . Journal of Cardiovascular Magnetic Resonance, 14(S1).
- . Journal of Neuroradiology, 39(4), 227-235.
- . Radiology, 263(3), 874-883.
- . Physics in Medicine and Biology, 57(11), 3609-3628.
- . Investigative Radiology, 47(6), 332-338.
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 184(S 01).
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 184(S 01).
- . Investigative Radiology, 47(4), 252-258.
- . Abdominal Imaging, 37(2), 164-179.
- . American Journal of Roentgenology, 198(2), 384-391.
- . Physics in Medicine and Biology, 57(2), R1-R33.
- . European Radiology, 22(1), 73-82.
- . Journal of Cardiovascular Magnetic Resonance, 13(S1).
- . Journal of Cardiovascular Magnetic Resonance, 13(S1).
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 183(12).
- . Magnetic Resonance in Medicine, 66(3), 735-745.
- . Investigative Radiology, 46(9), 594-599.
- . Journal of Magnetic Resonance Imaging, 34(3), 595-607.
- . Magnetic Resonance in Medicine, 65(5), 1491-1497.
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 183(S 01).
- . Journal of Magnetic Resonance Imaging, 33(3), 676-683.
- . European Journal of Radiology, 77(3), 528-528.
- . Journal of Biomedical Science and Engineering, 04(04), 315-319.
- . Interface Focus, 1(1), 101-116.
- . European Journal of Radiology, 77(2), 312-318.
- . Acta Radiologica, 51(10), 1163-1171.
- . Physics in Medicine and Biology, 55(21), 6431-6443.
- Determination of glomerular filtration rate using dynamic CT-angiography: simultaneous acquisition of morphological and functional information (vol 45, pg 387, 2010). INVESTIGATIVE RADIOLOGY, 45(8), 506-506.
- . Investigative Radiology, 45(7), 387-392.
- . European Journal of Radiology, 76(3), 298-303.
- . European Journal of Radiology, 76(3), 337-347.
- . Zeitschrift f眉r Medizinische Physik, 20(2), 101-114.
- . European Journal of Radiology, 76(3), 323-328.
- . European Journal of Radiology, 76(3), 304-313.
- . Academic Radiology, 17(4), 441-449.
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 182(S 01).
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 182(S 01).
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 182(S 01).
- . Journal of Magnetic Resonance Imaging, 31(3), 556-561.
- . Magnetic Resonance in Medicine, 63(3), 691-700.
- . Journal of Magnetic Resonance Imaging, 31(2), 490-501.
- . Magnetic Resonance in Medicine, 64(1), 115-124.
- . Investigative Radiology, 45(1), 7-14.
- . Journal of Magnetic Resonance Imaging, 31(1), 125-133.
- . European Journal of Cancer Supplements, 7(3), 18-18.
- . Magnetic Resonance in Medicine, 62(3), 672-681.
- . Magnetic Resonance in Medicine, 62(1), 205-217.
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 181(S 01).
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 181(S 01).
- . European Journal of Radiology, 69(3), 542-549.
- . Journal of Magnetic Resonance Imaging, 29(2), 398-403.
- Perfusion MRI for monitoring therapy effects in experimental chronic limb ischemia. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 11(Suppl 1).
- Differences in MR perfusion of malignant and benign cardiac tumors. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 11(Suppl 1).
- . Journal of Cardiovascular Magnetic Resonance, 11(S1).
- . Journal of Cardiovascular Magnetic Resonance, 11(S1).
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 181(01).
- . Investigative Radiology, 43(12), 877-892.
- . Radiology, 249(2), 471-482.
- . European Radiology, 18(6), 1260-1268.
- . Investigative Radiology, 43(2), 120-128.
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 180(S 1).
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 180(S 1).
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 180(S 1).
- . R枚Fo - Fortschritte auf dem Gebiet der R枚ntgenstrahlen und der bildgebenden Verfahren, 180(S 1).
- . Investigative Radiology, 43(1), 40-48.
- . European Journal of Radiology, 65(1), 59-65.
- . Physics in Medicine and Biology, 52(22), 6761-6778.
- . Abdominal Imaging, 32(6), 758-771.
- . Journal of Magnetic Resonance Imaging, 25(6), 1159-1167.
- . Topics in Magnetic Resonance Imaging, 18(2), 117-125.
- . Physics in Medicine and Biology, 52(2), 429-447.
- . Nieren- und Hochdruckkrankheiten, 36(12), 589-599.
- . Cancer Imaging, 5(Spec No A), s157-s172.
- . Magnetic Resonance in Medicine, 54(4), 841-849.
- ABSTRACTS : Scientific posters. Cancer imaging : the official publication of the International Cancer Imaging Society, 5(Spec No A), S157-S172.
- . Physics in Medicine and Biology, 49(14), 3307-3324.
- . Magnetic Resonance in Medicine, 52(1), 209-213.
- . Magnetic Resonance Imaging, 20(4), 327-336.
- . European Journal of Radiology, 38(1), 19-27.
- . Foundations of Physics Letters, 13(4), 357-367.
- . Magnetic Resonance Materials in Physics, Biology and Medicine.
- . Annals of Biomedical Engineering.
- . Physics in Medicine & Biology.
- . Journal of Magnetic Resonance Imaging.
- . Magnetic Resonance in Medicine.
- . Magnetic Resonance Materials in Physics, Biology and Medicine.
- . Magnetic Resonance in Medicine.
- . Magnetic Resonance in Medicine.
- . Journal of Magnetic Resonance Imaging.
- . Molecular Pharmaceutics.
- . Magnetic Resonance Materials in Physics, Biology and Medicine.
- . European Radiology.
- . Circulation.
- .
- . Journal of Nuclear Cardiology.
- . Diagnostics, 8(1), 3-3.
- . Cancer Imaging, 13(4), 557-566.
- . European Journal of Heart Failure.
Chapters
- , Advances in Magnetic Resonance Technology and Applications (pp. liii-lxxxvi). Elsevier
- , Methods in Pharmacology and Toxicology (pp. 627-651). Springer New York
- , Chirurgisches Forum und DGAV Forum 2010 (pp. 109-111). Springer Berlin Heidelberg
- , Clinical MR Neuroimaging (pp. 113-128). Cambridge University Press
Conference proceedings papers
- . 2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD), 4 November 2023 - 11 November 2023.
- . Heart, Vol. 101(Suppl 2) (pp A12.1-A12)
- . Heart, Vol. 101(Suppl 2) (pp A12.2-A13)
- . Heart, Vol. 99(suppl 2) (pp A60.2-A61)
- . Heart, Vol. 99(suppl 2) (pp A59-A60)
- (pp 356-358)
- . Medical Imaging 2008: Image Processing
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 3 July 2023 - 8 July 2023.
- . ISMRM Annual Meeting, 3 July 2023 - 8 July 2023.
- . ISMRM Annual Meeting, 3 July 2023 - 8 July 2023.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- Research group
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Post-doctoral fellows
- Kanishka Sharma (BEAt-DKD)
- Susmita Basak (HEPARIM)
Software engineers
- Joao de Souza (UKRIN-MAPS)
- Steve Shillitoe (TRISTAN)
PhD/MD students
- Eve Shalom (CFD in liver)
- Eve Lennie (spinal cord PET/MRI)
- Bashair al-Hummiany (CKD biomarkers)
- Fotis Tagkalakis (Motion correction)
- Mohamed El-Sharif (HEPARIM)
- Meaad Almusined (mechanical thrombectomy)
- Professional activities and memberships
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- Chair of the Open Source Initiative on Perfusion Imaging
- Chair of the COST Action CA16103 (PARENCHIMA) on Renal MRI Biomarkers
- Chair of the ISMRM perfusion study group
- Chair designate of the ISMRM annual meeting program committee
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