Dr Steven Reynolds
Clinical Medicine, School of Medicine and Population Health
Preclinical MRI Facility Manager
+44 114 215 9596
Full contact details
Clinical Medicine, School of Medicine and Population Health
C Floor
Royal Hallamshire Hospital
Glossop Road
91直播
S10 2JF
- Profile
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For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
In 2009, I joined the University of 91直播 as a Senior Research fellow on a CRUK funded programme grant. Here I set up the lab to study cancer metabolism by Hyperpolarised Magnetic Resonance Imaging and Spectroscopy (MRI/S). Previously, I held positions in industry both as part of GE Healthcare (2001-2006), developing scientific instruments, and Oxford Instruments (2006 鈥 2009), where I led the MRS facility and was responsible for project delivery using the HyperSense hyperpolarisation instrument. It was from these roles that I developed an interest in hyperpolarised magnetic resonance experiments and metabolism.
I have a degree in chemistry from Aston University, where I also received my PhD. I have held research positions at the University of Surrey and the University of Cambridge.
- Research interests
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My main research interest is in the use of (MRS) to study cellular metabolism and metabolomics. This is augmented by the use of hyperpolarisation technology that allows in vivo and in vitro cellular metabolism to be studied in real time.
The studies the metabolism of these unique cells to learn more about male factor infertility. Sperm undergo a lot of changes before fertilising an egg. These changes require energy and our research examines how sperm metabolise at different stages of their journey through the female reproductive tract. We use MRS to track the conversion of substrates by different metabolic pathways to understand how sperm produce this energy. Alongside this, I have a longstanding collaboration with Prof Dilly Anumba in studying the metabolic triggers of preterm birth. We examine how the bacteria present in the vagina can influence pregnancy outcomes. These bacteria produce metabolites that can be quantified by MRS and could be used to predict the likelihood of preterm birth.
I also manage the 7T and 9.4T magnetic resonance spectroscopy and imaging facility at the University of 91直播. Here I have a number of collaborations to develop the use of high resolution MRI, including live zebrafish imaging.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . PLOS ONE, 14(9), 222455-222455.
- . Molecular Human Reproduction, 25(1), 30-41.
- . Magnetic Resonance in Medicine, 78(6), 2116-2126.
- . Molecular Human Reproduction, 23(7), 441-451.
- . Scientific Reports, 7.
- . Frontiers in Medicine, 3.
- . Metabolomics, 12(4), 67-67.
- . Radiotherapy and Oncology, 116(3), 392-399.
- . NMR Biomed, 27(5), 610-616.
- . J Magn Reson, 239, 1-8.
- . Magn Reson Med, 70(4), 943-953.
- . Magnetic Resonance in Medicine, 62(5), 1300-1304.
- . Applied Magnetic Resonance, 34(3-4), 495-508.
- . Journal of the American Chemical Society, 130(14), 4598-4599.
- . Technologies, 5(1), 6-6.
All publications
Journal articles
- . Molecular Metabolism, 78.
- . Reproduction and Fertility, 3(3), L6-L8.
- . Reproduction and Fertility.
- . Reproduction and Fertility, 2(4), L4-L6.
- . PLOS ONE, 14(9), 222455-222455.
- . Molecular Human Reproduction, 25(1), 30-41.
- . Magnetic Resonance in Medicine, 78(6), 2116-2126.
- . Frontiers in Physiology, 8.
- . Molecular Human Reproduction, 23(7), 441-451.
- . Scientific Reports, 7.
- . Frontiers in Medicine, 3.
- . Metabolomics, 12(4), 67-67.
- . Radiotherapy and Oncology, 116(3), 392-399.
- . NMR Biomed, 27(5), 610-616.
- . J Magn Reson, 239, 1-8.
- . Magn Reson Med, 70(4), 943-953.
- Fully MR-Compatible Syringe Pump for the Controllable Injection of Hyperpolarized Substrate in Animals. Applied Magnetic Resonance, 1-11.
- . Magnetic Resonance in Medicine, 62(5), 1300-1304.
- . Applied Magnetic Resonance, 34(3-4), 495-508.
- . Journal of the American Chemical Society, 130(14), 4598-4599.
- . Journal of Molecular Biology, 366(1), 132-139.
- . NMR in Biomedicine.
- . Human Molecular Genetics.
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- . Technologies, 5(1), 6-6.
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- . NMR in Biomedicine.
Chapters
Conference proceedings papers
- Metabolic Characteristics of Vaginal Dysbiosis Associated Bacteria: Mobiluncus curtisii and Lactobacillus iners. REPRODUCTIVE SCIENCES, Vol. 30 (pp 192A-192A)
- Metabolic Profiling of Gardenerella vaginalis: A Vaginal Dysbiosis and Preterm Birth-Associated Bacteria.. REPRODUCTIVE SCIENCES, Vol. 28(SUPPL 1) (pp 215A-216A)
- Differential Vaginal Lactobacillus Species Metabolism of Glucose, L- and D-lactate by(13)C-Nuclear Magnetic Resonance Spectroscopy.. REPRODUCTIVE SCIENCES, Vol. 28(SUPPL 1) (pp 216A-216A)
- Differential Metabolic Profiles of Lactobacillus Species and Preterm Birth-associated Bacteria.. REPRODUCTIVE SCIENCES, Vol. 27(SUPPL 1) (pp 122A-122A)
- Discriminative Capacity of H-1-MRS Spectrum Binning for Preterm Delivery-Associated Lactobacilli-Dominated Vaginal Microbiota.. REPRODUCTIVE SCIENCES, Vol. 26 (pp 212A-212A)
- Decreased cervicovaginal fluid glutamate improves the predictive value of acetate for risk of preterm delivery within two weeks of presentation with threatened preterm labour. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol. 124 (pp 127-127)
- Prognostic Microbiomial and Metabolite Markers of Preterm Birth in Second Trimester Cervicovaginal Fluid from Women at Risk.. REPRODUCTIVE SCIENCES, Vol. 23 (pp 128A-128A)
- The Association of Cervicovaginal Fluid Metabolites at 20-22 Weeks Gestation with Quantitative Fetal Fibronectin, Ultrasound Cervical Length and Gestational Age at Delivery in Asymptomatic Pregnant Women.. REPRODUCTIVE SCIENCES, Vol. 23 (pp 190A-191A)
- Elucidating Potential Metabolite Markers of Preterm Birth in Cervicovaginal Secretions By Nuclear Magnetic Resonance Spectroscopy. REPRODUCTIVE SCIENCES, Vol. 22 (pp 130A-130A)
Preprints
- Research group
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PhD students
- Evie Gruszyk
- Teaching interests
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I deliver the MRI component of the FRCR (Radiology) programme to the Medical school Undergraduate course. I also contribute to the Student Selected Components on Phase 1b (Research Methods). I supervise Master students on the Reproductive and Developmental medicine course. Outside of the Medical school I provide research experiences for the University鈥檚 SURE scheme and .
- Professional activities and memberships
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- Member of the Royal Society of Chemistry.
- Member of the Institute for Physics.
Links