Dr Simon G Danby
BSc (Hon) PhD
Clinical Medicine, School of Medicine and Population Health
Senior Research Fellow
+44 114 215 9563
Full contact details
Clinical Medicine, School of Medicine and Population Health
Room K123
The Medical School
Beech Hill Road
91直播
S10 2RX
- Profile
-
For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
Originally trained in biochemistry and molecular biology I joined the University of 91直播 in 2005 as a post-doctoral scientist in the Academic Unit of Biomedical Genetics. In this position I worked exclusively for York Pharma on the early stage development of novel therapeutics and diagnostics for atopic dermatitis, psoriasis and malignant melanoma. In 2009 I joined 91直播 Dermatology Research as a post-doctoral Research Associate. The focus of my research in this role was improving our understanding of the structure and function of the epidermal (skin) barrier and its role in the development of disorders such as atopic dermatitis (AD). At the beginning of 2012 I was awarded a 3-year unencumbered research fellowship from Johnson & Johnson to continue my research on the skin barrier and set up a dedicated research facility for conducting human skin research. Since then I have continued to conduct and lead translational dermatology research as an independent fellow.
- Research interests
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The skin serves as an important barrier that keeps moisture in the body and prevents the incursion of harmful exogenous agents, such as irritants and allergens, and resists the invasion of pathogens. A growing body of evidence suggests a primary role for the 鈥榮kin barrier鈥 in the pathogenesis of a broad range of inflammatory skin disorders, including contact dermatitis, ichthyosis, psoriasis, rosacea and atopic dermatitis (AD). Repeated barrier disruption for instance induces epidermal hyperplasia and inflammation. Current medicine is based on the reactive treatment of these downstream consequences of skin barrier dysfunction, and includes the use of both anti-inflammatory and anti-proliferative compounds. My research focuses on increasing our understanding of the skin barrier defect and developing treatments to correct it under the following core themes:
- Gene-environment interactions in the development of atopic dermatitis
- Development of treatments for atopic dermatitis
- The improvement of neonatal skincare
- Interaction of topical pharmaceutical and cosmetic agents with the skin barrier
A greater understanding of the underlying skin barrier defect promises to firstly identify susceptible individuals early on, and secondly to deliver novel therapeutic options for targeted skin barrier repair with the potential to prevent the development of clinical disease.
Current Projects:
- Characterisation of the skin barrier defect in atopic dermatitis using ATR-FTIR spectroscopy
- Improving neonatal skincare: the Skin Testing for Atopic eczema Risk (STAR) study
- Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography
- Evaluation of topical emollients and bath/wash emollients
- Effect of topical anti-inflammatory treatments on the structure and function of the skin barrier
- Hygiene and emollient interventions for maintaining skin integrity in older people in hospital and residential care settings
- A Comparison between Optical Coherence Tomography (OCT) determined basal cell carcinoma (BCC) margins against surgeon excision margins and histology 鈥 an observational pilot study
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Journal of Allergy and Clinical Immunology.
- . Journal of the Mechanical Behavior of Biomedical Materials.
- . Journal of Investigative Dermatology, 138(1), 68-77.
- . Journal of Allergy and Clinical Immunology, 138(5), 1715-1719.e4.
- . British Journal of Dermatology, 175(5), 1011-1019.
- . British Journal of Dermatology, 175(4), 713-720.
- . Skin Pharmacology and Physiology, 29(3), 135-147.
- . Current Problems in Dermatology (Switzerland), 49, 47-60.
- . Acta Dermato Venereologica, 96(3), 323-330.
- . Acta Dermato Venereologica, 95(6), 653-658.
- . Cochrane Database of Systematic Reviews, 2014(12), 1-16.
- . Br J Dermatol, 170(4), 914-921.
- . Br J Dermatol, 165(2), 329-334.
- A New Understanding Of Atopic Dermatitis: The Role Of Epidermal Barrier Dysfunction And Subclinical Inflammation. Journal of Clinical Dermatology, 1, 33-46.
- . J Invest Dermatol, 129(8), 1892-1908.
Chapters
- Neonatal Skin Care and Toxicology In Eichenfield LF, Frieden IJ, Zaenglein A & Mathes E (Ed.), Neonatal and Infant Dermatology (pp. 46-56). Saunders
- Current and Future Trends: Skin Diseases and Treatment In Benson HAE & Watkinson AC (Ed.), Topical and Transdermal Drug Delivery Wiley
- The Skin Barrier in Atopic Dermatitis. In Irvine A, Hoeger P & Yan A (Ed.), Textbook of Pediatric Dermatology, UK: Blackwell Publishing Ltd..
- Epidermal Barrier Dysfunction in Atopic Dermatitis In Rawlings L (Ed.), Skin Moisturization USA: Informa Healthcare USA Inc..
Reports
All publications
Journal articles
- . Annales de Dermatologie et de V茅n茅r茅ologie - FMC, 4(8), A205-A206.
- . Journal of the American Academy of Dermatology, 91(3), AB34-AB34.
- . Journal of the American Academy of Dermatology, 91(3), AB34-AB34.
- . Journal of the American Academy of Dermatology, 91(3), AB259-AB259.
- . Skin Pharmacology and Physiology, 37, 49-58.
- . Journal of Investigative Dermatology, 144(8), S48-S48.
- . British Journal of Dermatology, 191(Supplement_1), i30-i30.
- . Drug Design, Development and Therapy, 18, 277-289.
- . Journal of Allergy and Clinical Immunology, 153(2), AB5-AB5.
- . Journal of Allergy and Clinical Immunology.
- . British Journal of Dermatology, 189(1), e24-e24.
- . Frontiers in Virology, 3.
- . The Journal of Allergy and Clinical Immunology: In Practice.
- . Experimental Dermatology.
- . Journal of Investigative Dermatology.
- . Journal of the Mechanical Behavior of Biomedical Materials, 127.
- . Annals of Allergy, Asthma & Immunology.
- . Clinical and Experimental Dermatology.
- . British Journal of Dermatology.
- . JID Innovations, 100011-100011.
- . Biomedical Optics Express.
- . Journal of the American Academy of Dermatology, 83(6), AB71-AB71.
- . Journal of Dermatological Treatment.
- . Dermatology and Therapy.
- . Journal of the Mechanical Behavior of Biomedical Materials.
- . BMJ Open, 9(8).
- . Journal of Investigative Dermatology, 138(11), 2295-2300.e1.
- . Br J Dermatol, 179(2), 246-247.
- . BioMed Research International, 2018.
- . Biomedical Optics Express, 9(4), 2001-2001.
- . Journal of Investigative Dermatology, 138(1), 68-77.
- . British Journal of Dermatology, 177(5), 1164-1164.
- . British Journal of Dermatology, 177(3), 608-609.
- . Royal Society of London. Philosophical Transactions A. Mathematical, Physical and Engineering Sciences, 375(2096).
- Biologic Treatments for Atopic Eczema: Anti IL-4 and IL-13 biologics. Exchange: National Eczema Society Members' Magazine(163), 11-18.
- . Journal of Allergy and Clinical Immunology, 138(5), 1715-1719.e4.
- . British Journal of Dermatology, 175(5), 1011-1019.
- . British Journal of Dermatology, 175(4), 713-720.
- . Skin Pharmacology and Physiology, 29(3), 135-147.
- . Current Problems in Dermatology (Switzerland), 49, 47-60.
- . Acta Dermato Venereologica, 96(3), 323-330.
- . Acta Dermato Venereologica, 95(6), 653-658.
- . Cochrane Database of Systematic Reviews, 2014(12), 1-16.
- . British Journal of Dermatology, 171(4), 688-688.
- . Br J Dermatol, 170(4), 914-921.
- . Br J Dermatol, 168(2), 235-236.
- . Photonic Therapeutics and Diagnostics IX.
- . Pediatr Dermatol, 30(1), 42-50.
- . British Journal of Dermatology, 164(6), 1179-1180.
- . Br J Dermatol, 165(2), 329-334.
- Use of oil for baby skincare: A survey of UK maternity and neonatal units. British Journal of Midwifery, 19(6), 354-362.
- . British Journal of Midwifery, 19(6), 354-362.
- A New Understanding Of Atopic Dermatitis: The Role Of Epidermal Barrier Dysfunction And Subclinical Inflammation. Journal of Clinical Dermatology, 1, 33-46.
- Expression of the multi-drug efflux genes acrAB of 'Escherichia coli'..
- . J Invest Dermatol, 129(8), 1892-1908.
- . British Journal of Nursing, 18(14), 872-877.
- Gene-environment interactions in atopic dermatitis. Drug Discovery Today: Disease Mechanisms, 5, e11-e31.
- . Drug Discovery Today: Disease Mechanisms, 5(1), e11-e31.
- . FEMS Microbiol Lett, 207(1), 91-95.
- . FEMS Microbiology Letters, 207(1), 91-95.
- . Applied Spectroscopy.
- . British Journal of Dermatology.
- . JEADV Clinical Practice.
- . British Journal of Dermatology.
- . Dermatology and Therapy.
- . Clinical and Experimental Dermatology.
- . Biomedical Optics Express.
- . Clinical & Experimental Allergy.
- . Clinical & Experimental Allergy.
- . Cochrane Database of Systematic Reviews.
- . Clinical and Experimental Dermatology.
- . Journal of Dermatological Treatment.
- . Dermatology and Therapy.
Chapters
- , pH of the Skin: Issues and Challenges (pp. 95-107). S. Karger AG
- Neonatal Skin Care and Toxicology In Eichenfield LF, Frieden IJ, Zaenglein A & Mathes E (Ed.), Neonatal and Infant Dermatology (pp. 46-56). Saunders
- Current and Future Trends: Skin Diseases and Treatment In Benson HAE & Watkinson AC (Ed.), Topical and Transdermal Drug Delivery Wiley
- The Skin Barrier in Atopic Dermatitis. In Irvine A, Hoeger P & Yan A (Ed.), Textbook of Pediatric Dermatology, UK: Blackwell Publishing Ltd..
- , Basic and Clinical Dermatology (pp. 211-240). Informa Healthcare
- Epidermal Barrier Dysfunction in Atopic Dermatitis In Rawlings L (Ed.), Skin Moisturization USA: Informa Healthcare USA Inc..
Conference proceedings papers
- . Journal of Investigative Dermatology, Vol. 143(11) (pp S342-S342)
- Dupilumab treatment normalizes skin barrier function and improves patient-reported outcomes in patients aged 6 to 11 years with moderate-to-severe atopic dermatitis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 143(11) (pp S342-S342)
- AN IN VITRO IMMUNOCOMPETENT HUMAN TISSUE-ENGINEERED MODEL OF ATOPIC DERMATITIS FOR DRUG TESTING. TISSUE ENGINEERING PART A, Vol. 29(11-12) (pp 492-492)
- . British Journal of Dermatology, Vol. 187(1) (pp E29-E29). Virtual, 29 March 2021 - 29 March 2021.
- . British Journal of Dermatology, Vol. 187(1) (pp E31-E31). Virtual, 29 March 2021 - 29 March 2021.
- EFFECTS OF EMOLLIENT CREAMS ON THE SKIN BARRIER OF PATIENTS WITH ATOPIC DERMATITIS. ACTA DERMATO-VENEREOLOGICA, Vol. 102 (pp 35-36)
- SKIN TESTING TO DETERMINE ATOPIC DERMATITIS RISK: AN OBSERVATIONAL BIRTH COHORT STUDY. ACTA DERMATO-VENEREOLOGICA, Vol. 102 (pp 15-15)
- A RANDOMIZED CONTROLLED PHASE 2 TRIAL COMPARING THE EFFECTS OF CRISABOROLE 2% OINTMENT TO BETAMETHASONE VALERATE 0.1% CREAM ON SKIN STRUCTURE IN PARTICIPANTS WITH ATOPIC DERMATITIS. ACTA DERMATO-VENEREOLOGICA, Vol. 102 (pp 56-57)
- Assessing the severity of striae distensae using polarization-sensitive optical coherence tomography. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187(1) (pp E22-E23)
- LOWERING SKIN SURFACE PH WITH A TOPICAL ZINC LACTOBIONATE PREPARATION CONTAINING PHYSIOLOGIC LIPIDS IMPROVES SKIN BARRIER STRUCTURE AND FUNCTION IN ADULTS WITH ATOPIC DERMATITIS. ACTA DERMATO-VENEREOLOGICA, Vol. 101 (pp 51-51)
- An investigation of the skin barrier restoring effects of a cream containing ceramides in a multivesicular emulsion in people with dry, eczema-prone, skin: The RESTORE study phase 2. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 83(6) (pp AB71-AB71)
- Quantification of natural moisturizing factors at the skin surface using a portable infrared spectrometer device: a pilot, calibration model. BRITISH JOURNAL OF DERMATOLOGY, Vol. 179(1) (pp E35-E36)
- . Proceedings of SPIE, Vol. 10037
- The role of domestic water hardness in the development of skin barrier dysfunction and atopic eczema: a systematic review of the literature. BRITISH JOURNAL OF DERMATOLOGY, Vol. 177 (pp 159-159)
- . Journal of Investigative Dermatology, Vol. 136(9) (pp S182-S182)
- A pilot, assessor-blinded, randomized controlled trial of topical oils for neonatal skin. BRITISH JOURNAL OF DERMATOLOGY, Vol. 173 (pp 153-153)
- Noninvasive assessment of the lipid structure and water holding properties of the stratum corneum in vivo by ATR-FTIR using a fibre optic probe in patients with atopic dermatitis and healthy controls. BRITISH JOURNAL OF DERMATOLOGY, Vol. 170(6) (pp E29-E29)
- The effect of a complex emollient cream containing 5% urea, ceramide 3 and lactic acid, compared with a simple emollient, on the skin barrier in older people with dry skin. BRITISH JOURNAL OF DERMATOLOGY, Vol. 171 (pp 57-58)
- Chymotrypsin-like protease activity in the stratum corneum is increased in atopic dermatitis and upon washing with soap. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 68(4) (pp AB172-AB172)
- Vitamin D supplementation improves atopic dermatitis and atopic dermatitis complicated by eczema herpeticum. BRITISH JOURNAL OF DERMATOLOGY, Vol. 167 (pp 127-127)
- A randomized comparison of aqueous cream and Oilatum庐 Junior bath additive on skin barrier function in atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 165 (pp 44-45)
- A randomized comparison of aqueous cream and Oilatum庐 Junior bath additive on skin barrier function in atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 165 (pp 115-115)
- Skin protease inhibitors: a new treatment for atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 161 (pp 30-31)
- . British Journal of Dermatology, Vol. 161 (pp 115-127)
- Skin protease inhibitors: A new treatment for atopic dermatitis. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 60(3) (pp AB67-AB67)
Reports
Posters
- Teaching interests
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- I teach on the undergraduate medical degree course (Common skin conditions and skin pharmacology) and on the Molecular Medicine MSc (Experimental medicine pathway, modules MED6020 & MED6021 Cellular and Molecular Basis of Disease)
- I supervise undergraduate BMedSci and Research Attachment SSC projects conducted within our dedicated skin barrier research suite
- I also deliver external educational presentations to healthcare professionals on topics covering skin physiology, skincare, atopic dermatitis and the mechanisms of topical therapies for atopic dermatitis
- Professional activities and memberships
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- Member of the European Society for Dermatological Research (ESDR)
- Manager of the 鈥淪kin Barrier Research Facility鈥 housing a range of bioinstrumentation for the assessment of human skin in vivo non-invasively
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