Nicklin, Martin, Dr

Dr Martin Nicklin

MA, PhD

Clinical Medicine, School of Medicine and Population Health

Senior Lecturer

m.nicklin@sheffield.ac.uk
+44 114 215 9541

The Medical School

Full contact details

Dr Martin Nicklin
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
91ֱ��
S10 2RX

Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

I joined the University of 91ֱ�� in October 1992 after studying for a PhD from 1980-1983, working on the biochemistry of cystatins (cysteine proteinase inhibitors) with Alan Barrett in Cambridge.

Then from 1984-1987 worked as a post-doctoral Damon Runyon-Walter Winchell fellow at SUNY Stony Brook with Eckard Wimmer on the replication of poliovirus (the connection being the viral cysteine proteinases) and then between 1988 and 1991 as a Junior Scientist at the Institute for Molecular Pathology in Vienna, where I worked on DNA-binding proteins Fos and Jun.

I began work at the University of 91ֱ�� on mapping, discovering and searching for the functions of interleukin-1-like proteins (which we surmised would exist and would also be important!) in mouse and human.

My research pathway has been from protein biochemistry through molecular biology into genetics and immunology.

Research interests

Interleukin-1 is powerful pleiotropic pro-inflammatory signalling protein that has been known since the early 1980s. However, its unique biological activity has really started to be identified in the past five years.

IL-1 has a single known functional receptor and another IL-1-like protein, IL-1 receptor antagonist (IL-1Ra) binds the receptor as a competitive inhibitor.

In collaboration with Austin Smith, we developed IL-1Ra-deficient mice and my group and collaborators have characterised two of the chronic inflammatory phenotypes that these mice develop.

Our mutations are available on BALB/c and C57BL/6 backgrounds. The strains develop different autoimmune conditions including elastic-vessel vasculitis, a psoriasis-like a skin inflammation and rheumatoid arthritis-like disease.

One of the most interesting findings, in collaboration with Leo Joosten and colleagues in Nijmegen, was the demonstration that early onset arthritis in the BALB/c strain is dependent on specific gut colonisation by microbes.

We had long suspected a microbial trigger on the basis of the timing and clustering of disease onset.

My other research interest is in defining the critical biological function of a group of IL-1-like proteins that now are collectively known as IL-36, whose genes we had previously helped identify and map.

We are working to identify essential functions that have led to active IL-1-like genes being present in all sequenced mammalian genomes and yet are specific to mammals.

I have recently been engaged in producing SARS-CoV2 antigens for Clinical Seroconversion assays in collaboration with colleagues in the Department and in the NHS Trust.

Current Projects:

Identifying the connection between IL-1Ra-deficiency and chronic inflammatory diseases.
Finding the essential biological functions of members of the interleukin-1 family of cytokines.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Phillips KLE, Jordan-Mahy N, Nicklin MJH & Le Maitre CL (2013) . Ann Rheum Dis, 72(11), 1860-1867.
Planck SR, Woods A, Clowers JS, Nicklin MJ, Rosenbaum JT & Rosenzweig HL (2012) . Ann Rheum Dis, 71(5), 753-760.
Marriott HM, Gascoyne KA, Gowda R, Geary I, Nicklin MJH, Iannelli F, Pozzi G, Mitchell TJ, Whyte MKB, Sabroe I & Dockrell DH (2012) . Infect Immun, 80(3), 1140-1149.
Nicklin MJH (2011) . Blood, 118(22), 5713-5714.
Mohanty ST, Kottam L, Gambardella A, Nicklin MJ, Coulton L, Hughes D, Wilson AG, Croucher PI & Bellantuono I (2010) . Arthritis Res Ther, 12(4), R149.
Koenders MI, Devesa I, Marijnissen RJ, Abdollahi-Roodsaz S, Boots AMH, Walgreen B, di Padova FE, Nicklin MJH, Joosten LAB & van den Berg WB (2008) . Arthritis Rheum, 58(11), 3461-3470.
Abdollahi-Roodsaz S, Joosten LAB, Koenders MI, Devesa I, Roelofs MF, Radstake TRDJ, Heuvelmans-Jacobs M, Akira S, Nicklin MJH, Ribeiro-Dias F & van den Berg WB (2008) . J Clin Invest, 118(1), 205-216.
Somm E, Henrichot E, Pernin A, Juge-Aubry CE, Muzzin P, Dayer J-M, Nicklin MJH & Meier CA (2005) . Diabetes, 54(12), 3503-3509.
Shepherd J & Nicklin MJH (2005) . Circulation, 111(23), 3135-3140.
Shepherd J, Little MC & Nicklin MJH (2004) . J Invest Dermatol, 122(3), 665-669.
Nicklin MJH, Barton JL, Nguyen M, FitzGerald MG, Duff GW & Kornman K (2002) . Genomics, 79(5), 718-725.

All publications

Journal articles

Jarju S, Wenlock RD, Danso M, Jobe D, Jagne YJ, Darboe A, Kumado M, Jallow Y, Touray M, Ceesay EA , Gaye H et al (2024) . Nature Communications, 15(1).
Williams DM, Hornsby HR, Shehata OM, Brown R, Gallis M, Meardon N, Newman TAH, Plowright M, Zafred D, Shun-Shion ASM , Hodder AJ et al (2023) . iScience, 107056-107056.
Colton H, Hodgson D, Hornsby H, Brown R, Mckenzie J, Bradley KL, James C, Lindsey BB, Birch S, Marsh L , Wood S et al (2022) . Wellcome Open Research, 6, 220.
Alsaffar FA, Mujamammi AH, Aldughaim MSK, Nicklin MJH & Barker MD (2022) . Genes and Diseases.
Colton H, Hodgson D, Hornsby H, Brown R, Mckenzie J, Bradley KL, James C, Lindsey BB, Birch S, Marsh L , Wood S et al (2021) . Wellcome Open Research, 6.
Sharaf N, Nicklin MJ & di Giovine FS (2014) . Cytokine, 68(1), 16-22.
Phillips KLE, Jordan-Mahy N, Nicklin MJH & Le Maitre CL (2013) . Ann Rheum Dis, 72(11), 1860-1867.
Vecile E, Dobrina A, Salloum FN, Van Tassell BW, Falcione A, Gustini E, Secchiero S, Crovella S, Sinagra G, Finato N , Nicklin MJ et al (2013) . PLoS One, 8(1), e53265.
Planck SR, Woods A, Clowers JS, Nicklin MJ, Rosenbaum JT & Rosenzweig HL (2012) . Ann Rheum Dis, 71(5), 753-760.
Marriott HM, Gascoyne KA, Gowda R, Geary I, Nicklin MJH, Iannelli F, Pozzi G, Mitchell TJ, Whyte MKB, Sabroe I & Dockrell DH (2012) . Infect Immun, 80(3), 1140-1149.
Nicklin MJH (2011) . Blood, 118(22), 5713-5714.
Mohanty ST, Kottam L, Gambardella A, Nicklin MJ, Coulton L, Hughes D, Wilson AG, Croucher PI & Bellantuono I (2010) . Arthritis Res Ther, 12(4), R149.
Koenders MI, Devesa I, Marijnissen RJ, Abdollahi-Roodsaz S, Boots AMH, Walgreen B, di Padova FE, Nicklin MJH, Joosten LAB & van den Berg WB (2008) . Arthritis Rheum, 58(11), 3461-3470.
Abdollahi-Roodsaz S, Joosten LAB, Koenders MI, Devesa I, Roelofs MF, Radstake TRDJ, Heuvelmans-Jacobs M, Akira S, Nicklin MJH, Ribeiro-Dias F & van den Berg WB (2008) . J Clin Invest, 118(1), 205-216.
Somm E, Cettour-Rose P, Asensio C, Charollais A, Klein M, Theander-Carrillo C, Juge-Aubry CE, Dayer J-M, Nicklin MJH, Meda P , Rohner-Jeanrenaud F et al (2006) . Diabetologia, 49(2), 387-393.
Magne D, Palmer G, Barton JL, Mézin F, Talabot-Ayer D, Bas S, Duffy T, Noger M, Guerne P-A, Nicklin MJH & Gabay C (2006) . Arthritis Res Ther, 8(3), R80.
Somm E, Henrichot E, Pernin A, Juge-Aubry CE, Muzzin P, Dayer J-M, Nicklin MJH & Meier CA (2005) . Diabetes, 54(12), 3503-3509.
Shepherd J & Nicklin MJH (2005) . Circulation, 111(23), 3135-3140.
Shepherd J, Little MC & Nicklin MJH (2004) . J Invest Dermatol, 122(3), 665-669.
Carl VS, Brown-Steinke K, Nicklin MJH & Smith MF (2002) . J Biol Chem, 277(20), 17448-17456.
Nicklin MJH, Barton JL, Nguyen M, FitzGerald MG, Duff GW & Kornman K (2002) . Genomics, 79(5), 718-725.
Tazi-Ahnini R, Cox A, McDonagh AJG, Nicklin MJH, di Giovine FS, Timms JM, Messenger AG, Dimitropoulou P, Duff GW & Cork MJ (2002) . Eur J Immunogenet, 29(1), 25-30.
Dunn E, Sims JE, Nicklin MJ & O'Neill LA (2001) . Trends Immunol, 22(10), 533-536.
Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, Kastelein RA, Kumar S, Lin H, Mulero JJ , Pan J et al (2001) . Trends Immunol, 22(10), 536-537.
Barton JL, Herbst R, Bosisio D, Higgins L & Nicklin MJ (2000) A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities.. Eur J Immunol, 30(11), 3299-3308.
Nicklin MJ, Hughes DE, Barton JL, Ure JM & Duff GW (2000) . J Exp Med, 191(2), 303-312.
Dale M & Nicklin MJ (1999) . Genomics, 57(1), 177-179.
Cox A, Camp NJ, Nicklin MJ, di Giovine FS & Duff GW (1998) . Am J Hum Genet, 62(5), 1180-1188.
Dale M, Hammond DW, Cox A & Nicklin MJ (1998) . Genomics, 47(2), 325-326.
Herbst R, Barton JL & Nicklin MJ (1997) . Genomics, 46(3), 480-482.
Cox A, Camp NJ, Nicklin MJH & Duff GW (1997) An analysis of linkage disequilibrium in the interleukin-1 gene cluster.. AMERICAN JOURNAL OF HUMAN GENETICS, 61(4), A272-A272.
Nothwang HG, Strahm B, Denich D, Kübler M, Schwabe J, Gingrich JC, Jauch A, Cox A, Nicklin MJ, Kurnit DM & Hildebrandt F (1997) . Genomics, 41(3), 370-378.
Herbst R & Nicklin MJ (1997) . Brain Res Mol Brain Res, 44(2), 309-322.
Clay FE, Tarlow JK, Cork MJ, Cox A, Nicklin MJ & Duff GW (1996) . Hum Genet, 97(6), 723-726.
Clay FE, Tarlow JK, Cork MJ, Cox A, Nicklin MJH & Duff GW (1996) . Human Genetics, 97(6), 723-726.
Hildebrandt F, Cybulla M, Strahm B, Nothwang HG, Singh-Sawhney I, Berz K, Nicklin M, Reiner O & Brandis M (1996) . Cytogenetic and Genome Research, 73(3), 235-239.
Cox A, Nicklin MJH, Hildebrand F & Duff GW (1996) Novel microsatellite markers in the interleukin-1 gene cluster. CYTOGENETICS AND CELL GENETICS, 73(4), 3-3.
Nicklin MJ, Weith A & Duff GW (1994) . Genomics, 19(2), 382-384.
Spurr NK, Kruse T & Naylor S (1994) . Cytogenetic and Genome Research, 67(4), 215-244.
NICKLIN MJH, KLENKA T & DUFF GW (1994) ANALYSIS OF THE INTERLEUKIN-1 GENE-CLUSTER. CYTOGENETICS AND CELL GENETICS, 67(4), 243-243.
Nicklin MJ, Zechner D & Kislyakova T (1993) Accumulated helix-destabilizing mutations in the leucine zipper of c-Fos leads to attenuation and temperature sensitivity of function.. Oncogene, 8(7), 1737-1749.
Harris KS, Reddigari SR, Nicklin MJ, Hämmerle T & Wimmer E (1992) . J Virol, 66(12), 7481-7489.
Nicklin MJ & Casari G (1991) A single site mutation in a truncated Fos protein allows it to interact with the TRE in vitro.. Oncogene, 6(1), 173-179.
Pallai PV, Burkhardt F, Skoog M, Schreiner K, Bax P, Cohen KA, Hansen G, Palladino DE, Harris KS & Nicklin MJ (1989) Cleavage of synthetic peptides by purified poliovirus 3C proteinase.. J Biol Chem, 264(17), 9738-9741.
Nicklin MJ, Harris KS, Pallai PV & Wimmer E (1988) . J Virol, 62(12), 4586-4593.
Jang SK, Kräusslich HG, Nicklin MJ, Duke GM, Palmenberg AC & Wimmer E (1988) . J Virol, 62(8), 2636-2643.
Kräusslich HG, Nicklin MJ, Lee CK & Wimmer E (1988) . Biochimie, 70(1), 119-130.
Kräusslich HG, Nicklin MJ, Toyoda H, Etchison D & Wimmer E (1987) . J Virol, 61(9), 2711-2718.
Nicklin MJ, Kräusslich HG, Toyoda H, Dunn JJ & Wimmer E (1987) . Proc Natl Acad Sci U S A, 84(12), 4002-4006.
Paul AV, Yang C-F, Jang S-K, Kuhn RJ, Tada H, Nicklin M, Krausslich H-G, Lee C-K & Wimmer E (1987) . Cold Spring Harbor Symposia on Quantitative Biology, 52(0), 343-352.
Wimmer E, Kuhn RJ, Pincus S, Yang CF, Toyoda H, Nicklin MJ & Takeda N (1987) . J Cell Sci Suppl, 7, 251-276.
Arnold E, Luo M, Vriend G, Rossmann MG, Palmenberg AC, Parks GD, Nicklin MJ & Wimmer E (1987) . Proc Natl Acad Sci U S A, 84(1), 21-25.
Toyoda H, Nicklin MJ, Murray MG, Anderson CW, Dunn JJ, Studier FW & Wimmer E (1986) . Cell, 45(5), 761-770.
Nicklin MJH, Toyoda H, Murray MG & Wimmer E (1986) . Nature Biotechnology, 4(1), 33-42.
Zucker S, Buttle DJ, Nicklin MJ & Barrett AJ (1985) . Biochim Biophys Acta, 828(2), 196-204.
Nicklin MJ & Barrett AJ (1984) . Biochem J, 223(1), 245-253.
Argos P, Kamer G, Nicklin MJ & Wimmer E (1984) . Nucleic Acids Res, 12(18), 7251-7267.
Anastasi A, Brown MA, Kembhavi AA, Nicklin MJ, Sayers CA, Sunter DC & Barrett AJ (1983) . Biochem J, 211(1), 129-138.
Colton H, Hodgson D, Hornsby H, Brown R, Mckenzie J, Bradley KL, James C, Lindsey BB, Birch S, Marsh L , Wood S et al () . Wellcome Open Research, 6, 220-220.
Partridge LJ, Urwin L, Nicklin MJH, James DC, Green LR & Monk PN () . Cells, 10(6), 1419-1419.

Chapters

Shepherd J & Nicklin MJH (2003) IL-1 Receptor Antagonist-Deficient Mice In Fantuzzi G (Ed.), Cytokine Knockouts (pp. 111-134). Humana Press
TOYODA H, NICKLIN MJH, MURRAY MG & WIMMER E (1973) , Protein Engineering (pp. 319-337). Elsevier

Conference proceedings papers

Rosenzweig HL, Planck SR, Woods AL, Clowers JS, Nicklin MJ & Rosenbaum JT (2011) The Discordant Impact of IL-1 Signaling on Experimental Uveitis and Arthritis.. ARTHRITIS AND RHEUMATISM, Vol. 63(10) (pp S26-S26)
Magne D, Palmer G, Barton JL, Mezin F, Talabot-Ayer D, Bas S, Duffy T, Gueme PA, Nicklin MJH & Gabay C (2006) The new IL-1 family member IL-1F8 stimulates the production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. ANNALS OF THE RHEUMATIC DISEASES, Vol. 65 (pp 77-78)
Shepherd J, Isles MM, Hughes DE & Nicklin MJH (2000) Inflammatory diseases in interleukin-1 receptor antagonist-deficient mice.. European Cytokine Network(11) (pp 200-200)

Preprints

Williams DM, Hornsby H, Shehata OM, Brown R, Zafred D, Shun-Shion ASM, Hodder AJ, Bliss D, Metcalfe A, Edgar JR , Gordon DE et al () , Cold Spring Harbor Laboratory.
Hodgson D, Colton H, Hornsby H, Brown R, Mckenzie J, Bradley KL, James C, Lindsey BB, Birch S, Marsh L , Wood S et al () .
Tee KL, Jackson PJ, Scarrott JM, Jaffe SRP, Johnson AO, Johari Y, Pohle TH, Mozzanino T, Price J, Grinham J , Brown A et al () .
Partridge LJ, Urwin L, Nicklin MJH, James DC, Green LR & Monk PN () .

Teaching interests

Currently my major teaching interest is in leading, developing and teaching the MSc in Molecular Medicine.

In 2010 our team (François Guesdon, Jon Shaw, Helen Marriott, Ilaria Bellantuono, Janine Kirby, Jane Shields and myself) won the Senate Award for 'Excellence in Collaboration in Teaching'.

We teach students up-to-date knowledge and technology. We also see the course as a means to develop students' skills in reading, thinking and writing like scientists.

This is an intense one-year masters course, featuring six months of taught modules and five months of lab work on an individual (selected) project.

The course is designed to train appropriate graduates in the reality of doing novel scientific research. We have taken on 420 students over the six years that I have led the course.

The course currently has pathways in "Genetic Mechanisms", "Experimental Medicine", "Neuroscience", "Cancer", "Cardovascular" and "Microbes and Infection".

Students can chose pathways after they have been with us for 10 weeks. I personally run modules entitled "From Genome to Gene Function" (MED6002) and "Genome and Sequence Analysis" (MED6005) which will also be available as Doctoral development modules, and I teach on two other modules as well as regularly supervising laboratory projects.

Professional activities and memberships

I am a long standing and active member of the University's Local Genetic Modification Committee and I sit on the School and Faculty Postgraduate Taught Programmes Committees.

I am Chair of the University of 91ֱ�� Biosafety Sub-committee.

91ֱ��

School of Medicine and Population Health

School of Medicine and Population Health

Dr Martin Nicklin

Current Projects:

Featured publications

Journal articles

All publications

Journal articles

Chapters

Conference proceedings papers

Preprints

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