Shah, Karan Mehul, Dr

Dr Karan Mehul Shah

PhD, MSc, B.Tech

Clinical Medicine, School of Medicine and Population Health

Research Associate

k.shah@sheffield.ac.uk
+44 114 215 9025

DU24, D Floor, The Medical School

Full contact details

Dr Karan Mehul Shah
Clinical Medicine, School of Medicine and Population Health
DU24, D Floor
The Medical School
Beech Hill Road
91ֱ��
S10 2RX

Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

I graduated with a B.Tech in Biotechnology at Amity University, Noida, India in 2008, and moved to 91ֱ�� to pursue an MSc in Molecular Medicine (2008-2009). Subsequently, I completed a NIHR Biomedical Research Unit for Musculoskeletal Disease funded PhD (2009-2014) investigating the effects of metal ions and nanoparticles on bone cell physiology under the mentorship of Prof Mark Wilkinson and Prof Alison Gartland.

To build on the findings from my PhD, I secured post-doctoral funding (2014-2016) from Orthopaedic Research UK (Grant Ref: 517) to investigate the molecular mechanisms that regulate the detrimental effects of metal debris on bone cells.

Since September 2016, I have been a post-doctoral researcher with Prof. Alison Gartland on a Breast Cancer Now funded study focussed on understanding the role of lysyl oxidase and purinergic signalling in breast cancer metastasis to bone.

Research interests

Metastatic cancer is the cause of most cancer-related deaths, and my current research interest is to understand how primary tumour facilitates pre-metastatic niche formation in specific distant organs. To that end, I am exploring the role of extracellular vesicles (EV) in metastasis and organotropism. Specifically, I am interested in the mechanisms that regulate EV release from tumour cells, and the effects these EVs have on the cells of the distant metastatic site, especially bone.

Funding and Awards:

Early Career Researcher Prize for Excellence in Outreach/Public Engagement and Excellence in Supervision/Teaching by Faculty of Medicine, Dentistry & Health, University of 91ֱ�� (2016).

Orthopaedic Research UK Post-doctoral Funding Co-applicant ‘Biological effects of tribocorrosion products on the bone microenvironment and prosthesis osseo-integration’ (£93,245.00).

William H. Harris Award for ‘outstanding work in orthopaedic research related to the hip’ awarded at the Orthopaedic Research Society Annual Meeting, New Orleans, USA (2014)

National Institute of Health Research Biomedical Research Fellowship (BRF-2011-013 and BRF-2011-020) for ‘T�� Effect of Metal Ions after Hip Resurfacing on Bone Cell Health’ (£71,187.00)

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Jiang W, Jin Y, Zhang S, Ding Y, Huo K, Yang J, Zhao L, Nian B, Zhong TP, Lu W , Zhang H et al (2022) . Bone Research, 10(1).
Jin Y, Liu Q, Chen P, Zhao S, Jiang W, Wang F, Li P, Zhang Y, Lu W, Zhong TP , Ma X et al (2022) . Cell Discovery, 8(1).
Tattersall L, Shah KM, Lath DL, Singh A, Down JM, De Marchi E, Williamson A, Di Virgilio F, Heymann D, Adinolfi E , Fraser WD et al (2021) . Journal of Bone Oncology, 31.
Shah KM, Dunning MJ, Gartland A & Wilkinson JM (2021) . International Journal of Molecular Sciences, 22(10).
Steinberg J, Southam L, Fontalis A, Clark MJ, Jayasuriya RL, Swift D, Shah KM, Brooks RA, McCaskie AW, Wilkinson JM & Zeggini E (2021) . Annals of the Rheumatic Diseases.
Steinberg J, Southam L, Roumeliotis TI, Clark MJ, Jayasuriya RL, Swift D, Shah KM, Butterfield NC, Brooks RA, McCaskie AW , Bassett JHD et al (2021) . Nature Communications, 12.
Steinberg J, Shah KM, Gartland A, Zeggini E & Wilkinson JM (2017) . Journal of Orthopaedic Research, 35(10), 2323-2328.
Shah KM, Orton P, Mani N, Wilkinson JM & Gartland A (2016) . Journal of Orthopaedic Research.
Shah KM, Wilkinson JM & Gartland A (2015) . Journal of Orthopaedic Research, 33(11), 1663-1670.
Shah KM, Quinn PD, Gartland A & Wilkinson JM (2015) . Journal of Orthopaedic Research, 33(1), 114-121.
Andrews RE, Shah KM, Wilkinson JM & Gartland A (2011) . Bone, 49(4), 717-723.

Preprints

Shah KM, Tattersall L, Hussain A, Macfarlane SC, Williamson A, Acosta-Martin AE, Erler JT, Ottewell PD & Gartland A () , Cold Spring Harbor Laboratory.

All publications

Journal articles

Gao J, Pei H, Lv F, Niu X, You Y, He L, Hu S, Shah KM, Liu M, Chen Y , Du B et al (2024) . Journal of Orthopaedic Translation, 44, 60-71.
Gao J, Pei H, Lv F, Niu X, You Y, He L, Hu S, Shah KM, Liu M, Chen Y , Du B et al (2024) . Journal of Orthopaedic Translation.
He L, Xu Z, Niu X, Li R, Wang F, You Y, Gao J, Zhao L, Shah KM, Fan J , Liu M et al (2023) . Acta Pharmaceutica Sinica B.
Green D, Singh A, Tippett VL, Tattersall L, Shah KM, Siachisumo C, Ward NJ, Thomas P, Carter S, Jeys L , Sumathi V et al (2023) . Journal of Bone Oncology, 39, 100474-100474.
Tattersall L, Gagui DC, Tippett VL, Latif NBA, Shah KM & Gartland A (2022) . Frontiers in Bioscience-Landmark, 27(4).
Jiang W, Jin Y, Zhang S, Ding Y, Huo K, Yang J, Zhao L, Nian B, Zhong TP, Lu W , Zhang H et al (2022) . Bone Research, 10(1).
Jin Y, Liu Q, Chen P, Zhao S, Jiang W, Wang F, Li P, Zhang Y, Lu W, Zhong TP , Ma X et al (2022) . Cell Discovery, 8(1).
Liu Y, Shah KM & Luo J (2021) . Frontiers in Bioengineering and Biotechnology, 9.
Tattersall L, Shah KM, Lath DL, Singh A, Down JM, De Marchi E, Williamson A, Di Virgilio F, Heymann D, Adinolfi E , Fraser WD et al (2021) . Journal of Bone Oncology, 31.
Shah KM, Dunning MJ, Gartland A & Wilkinson JM (2021) . International Journal of Molecular Sciences, 22(10).
Steinberg J, Southam L, Fontalis A, Clark MJ, Jayasuriya RL, Swift D, Shah KM, Brooks RA, McCaskie AW, Wilkinson JM & Zeggini E (2021) . Annals of the Rheumatic Diseases.
Steinberg J, Southam L, Roumeliotis TI, Clark MJ, Jayasuriya RL, Swift D, Shah KM, Butterfield NC, Brooks RA, McCaskie AW , Bassett JHD et al (2021) . Nature Communications, 12.
Marino S, Carrasco G, Li B, Shah KM, Lath DL, Sophocleous A, Lawson MA & Idris AI (2020) . Calcified Tissue International.
MacInnes SJ, Hatzikotoulas K, Fenstad AM, Shah K, Southam L, Tachmazidou I, Hallan G, Dale H, Panoutsopoulou K, Furnes O , Zeggini E et al (2019) . Clinical Orthopaedics & Related Research, 477(3), 668-668.
MacInnes SJ, Hatzikotoulas K, Fenstad AM, Shah K, Southam L, Tachmazidou I, Hallan G, Dale H, Panoutsopoulou K, Furnes O , Zeggini E et al (2019) . Clinical Orthopaedics and Related Research, 477(2), 297-309.
Hatzikotoulas K, Roposch A, Case Control Consortium DDH, Shah KM, Clark MJ, Bratherton S, Limbani V, Steinberg J, Zengini E, Warsame K , Ratnayake M et al (2018) . Communications Biology, 1.
Steinberg J, Ritchie GRS, Roumeliotis TI, Jayasuriya RL, Clark MJ, Brooks RA, Binch ALA, Shah KM, Coyle R, Pardo M , Le Maitre CL et al (2017) . Scientific Reports, 7(1).
Steinberg J, Shah KM, Gartland A, Zeggini E & Wilkinson JM (2017) . Journal of Orthopaedic Research, 35(10), 2323-2328.
Shah KM, Orton P, Mani N, Wilkinson JM & Gartland A (2016) . Journal of Orthopaedic Research.
Shah KM, Stern MM, Stern AR, Pathak JL, Bravenboer N & Bakker AD (2016) . BoneKEy Reports, 5.
Shah KM, Wilkinson JM & Gartland A (2015) . Journal of Orthopaedic Research, 33(11), 1663-1670.
Shah KM, Quinn PD, Gartland A & Wilkinson JM (2015) . Journal of Orthopaedic Research, 33(1), 114-121.
Andrews RE, Shah KM, Wilkinson JM & Gartland A (2011) . Bone, 49(4), 717-723.
Lawrence SR & Shah KM () . Biology, 13(9), 694-694.
Tippett VL, Tattersall L, Ab Latif NB, Shah KM, Lawson MA & Gartland A () . Oncogene.
Hatzikotoulas K, Roposch A, Shah K, Clark M, Bratherton S, Limbani V, Steinberg J, Zengini E, Warsame K, Ratnayake M , Tselepi M et al () .

Conference proceedings papers

Hatzikotoulas K, Roposch A, Shah KM, Clark MJ, Bratherton S, Limbani V, Warsame K, Ratnayake M, Tselepi M, Schwartzentruber J , Steinberg J et al (2017) . Osteoarthritis and Cartilage, Vol. 25 (pp S36-S37), 27 April 2017 - 30 April 2017.
Steinberg J, Ritchie G, Roumeliotis T, Jayasuriya R, Brooks R, Binch A, Shah K, Coyle R, Pardo M, Le Maitre C , Ramos Y et al (2017) . Osteoarthritis and Cartilage, Vol. 25 (pp S209-S210)
Shah K, Quinn P, Wilkinson M & Gartland A (2012) SPECIATION AND DISTRIBUTION OF COBALT AND CHROMIUM IN OSTEOBLASTS AND OSTEOCLASTS USING MICROFOCUS X-RAY FLUORESCENCE AND X-RAY ABSORPTION NEAR-EDGE STRUCTURE. OSTEOPOROSIS INTERNATIONAL, Vol. 23 (pp S592-S592)
Shah K, Patel V, Wang N & Gartland A (2010) The Effect of ATP on cancer cell proliferation in vitro -involvement of multiple P2X Receptors. PURINERGIC SIGNALLING, Vol. 6(1) (pp 140-140)

Preprints

Katsoula G, Arruda AL, Tutino M, Kreitmaier P, Shah KM, Swift D, Southam L, Wilkinson JM & Zeggini E (2024) , Cold Spring Harbor Laboratory.
Shah KM, Tattersall L, Hussain A, Macfarlane SC, Williamson A, Acosta-Martin AE, Erler JT, Ottewell PD & Gartland A () , Cold Spring Harbor Laboratory.
Tattersall L, Shah KM, Lath DL, Singh A, Down JM, De Marchi E, Williamson A, Di Virgilio F, Heymann D, Adinolfi E , Fraser WD et al () .
Steinberg J, Southam L, Butterfield NC, Roumeliotis TI, Fontalis A, Clark MJ, Jayasuriya RL, Swift D, Shah KM, Curry KF , Brooks RA et al () , Cold Spring Harbor Laboratory.
Steinberg J, Ritchie GRS, Roumeliotis TI, Jayasuriya RL, Brooks RA, Binch ALA, Shah KM, Coyle R, Pardo M, Le Maitre CL , Ramos YFM et al () , Cold Spring Harbor Laboratory.