Dr Helen Marshall
PhD
Clinical Medicine, School of Medicine and Population Health
Research Staff Scientist
+44 114 215 9145
Full contact details
Clinical Medicine, School of Medicine and Population Health
Polaris
18 Claremont Crescent
91直播
S10 2TA
- Profile
-
For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
I have worked on the development and application of hyperpolarised gas and proton lung MRI at the University of 91直播 since 2009. Previously I was a post-doctoral fellow at the University of Toronto working on dynamic contrast-enhanced breast imaging. I have a PhD in MRI Physics and a BSc in Physics from Imperial College London.
- Research interests
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My research interests are focused on the application of MR imaging techniques in patients with lung disease. Projects that I have worked on include:
- early detection of lung disease in children with cystic fibrosis
- visualisation of collateral and delayed ventilation in patients with advanced chronic obstructive pulmonary disease (COPD)
- imaging of ventilation response to therapies in patients with asthma and COPD
- visualisation of ventilation and perfusion matching in patients with chronic thromboembolic pulmonary hypertension, asthma and COPD
- imaging ventilation and microstructural changes in young adults with congenital diaphragmatic hernia
I am involved in clinical research study design and delivery, devising MR acquisition protocols and image computing workflows, and performing data analysis and interpretation. I helped to establish and am active in maintaining our clinical hyperpolarised gas lung imaging service.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . European Respiratory Journal, 7(3).
- . The British Journal of Radiology, 94.
- . Progress in Nuclear Magnetic Resonance Spectroscopy, 122, 42-62.
- . Journal of Allergy and Clinical Immunology.
- . Journal of Magnetic Resonance Imaging, 49(4), 1195-1197.
- . American Journal of Respiratory and Critical Care Medicine, 197(3).
- . Thorax, 72(8), 760-762.
- . Pediatric Pulmonology, 51(5), 517-524.
- . American Journal of Respiratory and Critical Care Medicine, 190(5), e18-e19.
- . Magn Reson Med, 71(3), 1172-1178.
- . Thorax, 67(7), 613-617.
All publications
Journal articles
- . Magnetic Resonance in Medicine.
- . Magnetic Resonance in Medicine.
- . Radiotherapy and Oncology, 194, S5062-S5066.
- . Scientific Reports, 13.
- . Medical Physics.
- . Chest.
- . ERJ Open Research, 9(1).
- . Journal of Magnetic Resonance Imaging.
- . American Journal of Respiratory and Critical Care Medicine.
- . Scientific Reports, 12(1).
- . Respiratory Research, 23(1).
- . European Respiratory Journal, 7(3).
- . The British Journal of Radiology, 94.
- . Progress in Nuclear Magnetic Resonance Spectroscopy, 122, 42-62.
- . Journal of Allergy and Clinical Immunology.
- , 24-35.
- . Journal of Cystic Fibrosis.
- . Thorax, 74(5), 500-502.
- . Physics in Medicine and Biology.
- . Journal of Magnetic Resonance Imaging, 49(4), 1195-1197.
- . International Journal of Radiation Oncology, Biology, Physics, 102(4), 1276-1286.
- . Journal of Applied Physiology.
- . European Respiratory Journal, 52(5).
- . Annals of the American Thoracic Society, 15(12), 1487-1490.
- . Journal of Magnetic Resonance Imaging, 48(3), 632-642.
- . American Journal of Respiratory and Critical Care Medicine, 197(3).
- . Radiology, 284(3).
- . Journal of Magnetic Resonance Imaging.
- . Thorax, 72(8), 760-762.
- . Cancer Research, 77(4_Supplement).
- . Magnetic Resonance in Medicine.
- . Pediatric Pulmonology, 51(5), 517-524.
- . Radiology, 278(2), 585-592.
- . Current Cardiovascular Imaging Reports, 8(12).
- . Journal of Applied Physiology, 119(9), 1007-1014.
- . Magnetic Resonance in Medicine, 74(1), 196-207.
- . Physics in Medicine and Biology, 59(23), 7267-7277.
- . NMR in Biomedicine, 27(12), 1461-1467.
- . American Journal of Respiratory and Critical Care Medicine, 190(5), e18-e19.
- . Pulm Circ, 4(1), 61-70.
- . J Appl Physiol (1985), 116(2), 129-139.
- . Magn Reson Med, 71(3), 1172-1178.
- Comparison of lung ventilation volume measurements made with single and separate breath-hold hyperpolarized 3-helium and proton MRI. EUROPEAN RESPIRATORY JOURNAL, 42.
- . Radiology, 267(1), 251-255.
- . Magn Reson Med, 67(2), 322-325.
- . Insights Imaging, 3(4), 345-353.
- . NMR in Biomedicine, 25(2), 389-399.
- . Magn Reson Med, 68(6), 1900-1904.
- . Thorax, 67(7), 613-617.
- . Eur Radiol, 22(3), 695-702.
- . NMR Biomed, 25(1), 44-51.
- . Magn Reson Med, 66(6), 1788-1797.
- . NMR Biomed, 24(2), 130-134.
- . Journal of Magnetic Resonance Imaging, 31(2), 328-338.
- . Magnetic Resonance Materials in Physics, Biology and Medicine, 22(3), 187-200.
- . American Journal of Roentgenology, 179(1), 187-192.
- . ERJ Open Research, 00442-2024.
- . European Respiratory Journal, 2301010-2301010.
- . Journal of Magnetic Resonance Imaging.
- . Journal of Magnetic Resonance Imaging.
- . Journal of Magnetic Resonance Imaging.
- . Pulmonary Circulation.
- . European Respiratory Journal, 2000441-2000441.
- Quantification of pulmonary perfusion in idiopathic pulmonary fibrosis with first pass dynamic contrast enhanced perfusion MRI. Thorax.
- . Journal of Magnetic Resonance Imaging.
Chapters
Conference proceedings papers
- . 鈥楾he Catcher in the MRI鈥 鈥 Functional imaging in lung disease (pp A8-A8)
- . Imaging (pp PA5251-PA5251)
- . Paediatric respiratory physiology and sleep (pp OA4664-OA4664)
- . Respiratory function technologists/scientists (pp OA4590-OA4590)
- . Physiotherapists (pp PA1430-PA1430)
- . 鈥楽hake it off鈥 鈥 Recovery from COVID-19
- . 鈥榊ou ain鈥檛 seen nothing yet鈥 鈥 Imaging across COPD, nodules and lung cancer screening
- . 鈥榊ou ain鈥檛 seen nothing yet鈥 鈥 Imaging across COPD, nodules and lung cancer screening
- . Imaging
- . Physiotherapists
- . Respiratory function technologists/scientists
- . Respiratory function technologists/scientists
- . Clinical respiratory physiology, exercise and functional imaging
- . Clinical respiratory physiology, exercise and functional imaging
- . 05.02 - Monitoring airway disease
- . 09.01 - Respiratory function technologists/scientists
- . 14.02 - Imaging
- . A99. LOOK AT THAT! NEW FINDINGS FROM LUNG IMAGING (pp a2175-a2175)
- . Imaging
- Hyperpolarized Gas MRI Ventilation Synthesis From CT: Comparison of Conventional and Deep Learning Methods. MEDICAL PHYSICS, Vol. 48(6)
- Comparison of 3D Deep Convolutional Neural Networks and Training Strategies for Ventilated Lung Segmentation Using Multi-Nuclear Hyperpolarized Gas MRI. MEDICAL PHYSICS, Vol. 48(6)
- . Imaging
- . Cystic fibrosis
- . Respiratory function technologists/scient.
- . Imaging
- . Cystic fibrosis
- . Journal of Cystic Fibrosis, Vol. 18 (pp S32-S32)
- . Journal of Cystic Fibrosis, Vol. 18 (pp S117-S117)
- . Journal of Cystic Fibrosis, Vol. 18 (pp S116-S117)
- . Journal of Cystic Fibrosis, Vol. 18 (pp S117-S117)
- . Radiotherapy and Oncology, Vol. 133 (pp S274-S275)
- . Thorax, Vol. 73(Suppl 4) (pp A44-A45). London, UK, 5 December 2018 - 7 December 2018.
- . Imaging
- . Cystic fibrosis
- . Radiotherapy and Oncology, Vol. 127(Supplement 1) (pp S96-S97). Barcelona, Spain, 20 April 2018 - 24 April 2018.
- Hyperpolarised Gas MRI Shows Reversibility of Lung Ventilation Defects at Increased Inspiratory Lung Volumes in Cystic Fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 197
- Dynamic Contrast-Enhanced Magnetic Resonance Imaging for the Evaluation of Perfusion Heterogeneity in Idiopathic Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 197
- Assessment of Suitable Patients and Targets for Lung Volume Reduction with Endobronchial Valves in COPD. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 197
- . Paediatric Respiratory Physiology and Sleep
- . European Respiratory Journal, Vol. 50(Suppl 61). Milan, Italy, 9 September 2017 - 13 September 2017.
- . Imaging
- . Cystic Fibrosis
- . Journal of Thoracic Oncology, Vol. 12(1) (pp S1050-S1050)
- . Pediatric Pulmonology, Vol. 51 (pp 348-348)
- . European Respiratory Journal, Vol. 48(suppl 60), 3 September 2016 - 7 September 2016.
- . 9.1 Respiratory Function Technologists/Scientists
- . 9.1 Respiratory Function Technologists/Scientists
- . European Respiratory Journal, Vol. 48(Suppl 60). Estoril, Portugal, 10 March 2016 - 13 March 2016.
- . Medical Physics, Vol. 43(6) (pp 3795-3796), 31 July 2016 - 4 August 2016.
- . Journal of Cystic Fibrosis, Vol. 15 (pp S24-S25)
- . Thorax, Vol. 70(Suppl 3) (pp A222-A223)
- . Thorax, Vol. 70(Suppl 3) (pp A223.1-A223)
- . Thorax, Vol. 70(Suppl 3) (pp A220.3-A221)
- . 1.3 Imaging
- . 4.1 Clinical respiratory physiology, exercise and functional imaging
- . 4.1 Clinical respiratory physiology, exercise and functional imaging
- . 1.3 Imaging
- . 9.1 Respiratory Function Technologists/Scientists
- . 4.1 Clinical respiratory physiology, exercise and functional imaging
- . Thorax, Vol. 69(Suppl 2) (pp A192-A193)
- Visualising regional ventilation heterogeneity by linking multiple breath washout to He-3 MRI imaging. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Quantitative lung T-1 mapping and oxygen enhanced MRI in IPF. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Delayed gas filling imaged in asthma patients using hyperpolarised He-3 MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Age-dependent changes in whole-lung septal thickness measured by Xe-129 MRI: A comparison of healthy volunteers and subjects with IPF. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Detection of early-stage lung disease in cystic fibrosis; comparing the sensitivity of He-3 and H-1 MRI, CT and LCI. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Feasibility of high quality lung MRI with naturally abundant hyperpolarised Xe-129. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- Age-dependent changes in whole-lung septal thickness measured by Xe-129 MRI: A comparison of healthy volunteers and subjects with IPF. EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- . Journal of Cystic Fibrosis, Vol. 13 (pp S28-S28)
- Linking Helium-3 Mri Washout Imaging To Multiple Breath Washout - First Steps To Understanding Regional Lung Ventilation Heterogeneity. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Dissolved 129xe Mri - Delayed Gas Uptake Indicates Septal Thickening In Patients With Idiopathic Pulmonary Fibrosis And Systemic Sclerosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Quantitative Mapping Of Treatment Response In The Lungs Of Asthmatics Using Hyperpolarized Ventilation Helium-3 Mri. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Reproducibility Of Lung Ventilation Volume From Helium-3 And Proton Mri In Asthmatics. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Assessment Of Structural And Functional Changes In Early Stage Cf With Helium-3 Mri, CT And Multi-Breath Washout. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Mutli-Nuclear Mr Imaging Of Vq Distribution Response To Bronchodilator In Asthma. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- Mapping The Microscopic Distribution Of Acinar Airway Length Scales Using Fractal Exponential Analysis Of Helium-3 Diffusion Mri. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 189
- . THORAX, Vol. 68 (pp A7-A8)
- Bronchodilator treatment response mapping in COPD using hyperpolarised gas ventilation MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 42
- Quantifying peripheral and central lung response to bronchodilator in asthma with hyperpolarised gas MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 42
- Imaging of bronchodilator effects in COPD with hyperpolarised He-3 and H-1 MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 42
- (HE)-H-3 MRI IN YOUNG ADULTS WITH CONGENITAL DIAPHRAGMATIC HERNIA: ALVEOLAR SIZE DIFFERENCES BETWEEN THE IPSI- AND CONTRALATERAL LUNG. INTENSIVE CARE MEDICINE, Vol. 39 (pp S107-S107)
- Imaging The Effect Of Airway Opening In Asthma Due To Inflation State With 3he Mri. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 187
- Modelling of hyperpolarized gas diffusion in lungs of COPD patients and healthy volunteers using a fractional dynamics approach. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- He-3 MRI in young adults with congenital diaphragmatic hernia: Alveolar size differences between lungs. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- MRI of delayed-ventilation perfusion matching in COPD. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- Quantifying lung function in COPD with hyperpolarised He-3 MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- Simultaneous imaging of lung structure and function with triple nuclear MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- Simultaneous imaging of lung structure and function with triple nuclear MRI. EUROPEAN RESPIRATORY JOURNAL, Vol. 40
- . D100. THE BIG ROLE OF SMALL AIRWAYS
- . B98. NOVEL APPROACHES TO LUNG IMAGING
- . C28. DIAGNOSIS AND TREATMENT OF PULMONARY HYPERTENSION
- . THORAX, Vol. 66 (pp A54-A55)
- AUTOMATIC IMAGE REGISTRATION OF LUNG CT WITH SYNCHRONOUSLY ACQUIRED HYPERPOLARIZED HELIUM-3 MRI AND PROTON MRI FOR PATIENTS WITH NSCLC. J THORAC ONCOL, Vol. 6(6) (pp S1123-S1124)
- . Radiotherapy and Oncology, Vol. 99 (pp S481-S482)
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 4 May 2024 - 9 May 2024.
- . ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
- . ISMRM Annual Meeting, 3 July 2023 - 8 July 2023.
- . ISMRM Annual Meeting, 3 July 2023 - 8 July 2023.
- . ISMRM Annual Meeting, 3 July 2023 - 8 July 2023.
- . ISMRM Annual Meeting, 3 July 2023 - 8 July 2023.
- . ISMRM Annual Meeting, 3 July 2023 - 8 July 2023.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
- . ISMRM Annual Meeting, 7 May 2022 - 12 May 2022.
Other
Preprints
- Current projects
- Imaging a large cohort of patients with asthma and/or COPD with 129Xe MRI as a sub-study of the .
- Comparison of hyperpolarised gas and free-breathing proton ventilation MRI in patients with cystic fibrosis.
- Imaging the effects of mepolizumab in patients with COPD.