Wells, Greg, Dr

Dr Greg Wells

BSc (Hons), PhD.

Clinical Medicine, School of Medicine and Population Health

Ex vivo Project Lead

g.wells@sheffield.ac.uk
+44 114 215 9077

+44 114 215 9098

FU03, F Floor, The Medical School

Full contact details

Dr Greg Wells
Clinical Medicine, School of Medicine and Population Health
FU03, F Floor
The Medical School
Beech Hill Road
91ֱ��
S10 2RX

Profile

For enquiries, please contact - SMPH-West-Operational@sheffield.ac.uk

I studied biomedical science at 91ֱ�� Hallam University in 2013 where I was awarded the President’s Prize from the Institute of Biomedical Science, the Undergraduate Prize from the British Society for Immunology, and the Pfizer Global R&D Prize for best performance in Analytical Science.

Following this I worked in industry, designing and validating genetic based assays for clinical trials in a GLP compliant laboratory. I then undertook a PhD between the University of 91ֱ��, 91ֱ�� Diagnostics Genetics Services NHS and AstraZeneca investigating genetics biomarkers and transcriptomic signatures in lung cancer.

In 2020 I established the ex vivo drug screening group at the University of 91ֱ��.

Research interests

My research interests are developing and advancing clinically relevant methods of patient stratification to targeted oncology therapeutics. Genetic biomarkers have dominated personal medicine for the last 20 years, but it is becoming clear that one molecular aberration may not drive the whole neoplastic process, so this approach does not always result in responses to molecular targeted therapy.

At the University of 91ֱ�� alongside collaborators we are developing a phenotypic drug screen which can be used directly on a patient’s biopsy or surgical tissue to generate a pharmacological profile of the patient’s tumour. We are currently testing this methodology in the proof of concept Ex VIvo DEtermiNed cancer Therapy (EVIDENT) trial. Our aim is to develop this into a predictive diagnostic test used to direct cancer patients’ treatment, adding an extra dimension to precision medicine.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Rahman MM, Wells G, Rantala JK, Helleday T, Muthana M & Danson SJ (2024) . Expert Review of Clinical Immunology.
Gagg H, Williams ST, Conroy S, Myers KN, McGarrity-Cottrell C, Jones C, Helleday T, Rantala J, Rominiyi O, Danson SJ , Collis SJ et al (2023) . F1000Research, 12.
Williams ST, Wells G, Conroy S, Gagg H, Allen R, Rominiyi O, Helleday T, Hullock K, Pennington CEW, Rantala J , Collis SJ et al (2022) . Expert Reviews in Molecular Medicine, 24.
Mäkelä R, Härmä V, Fajardo NB, Wells G, Lygerou Z, Sangfelt O, Kononen J & Rantala JK (2021) . Oncotarget.

All publications

Journal articles

Rahman MM, Wells G, Rantala JK, Helleday T, Muthana M & Danson SJ (2024) . Expert Review of Clinical Immunology.
Gagg H, Williams ST, Conroy S, Myers KN, McGarrity-Cottrell C, Jones C, Helleday T, Rantala J, Rominiyi O, Danson SJ , Collis SJ et al (2023) . F1000Research, 12.
Williams ST, Wells G, Conroy S, Gagg H, Allen R, Rominiyi O, Helleday T, Hullock K, Pennington CEW, Rantala J , Collis SJ et al (2022) . Expert Reviews in Molecular Medicine, 24.
Mäkelä R, Härmä V, Fajardo NB, Wells G, Lygerou Z, Sangfelt O, Kononen J & Rantala JK (2021) . Oncotarget.
Silva S, Danson S, Teare MD, Taylor F, Bradford J, McDonagh A, Salawu A, Wells G, Burghel G, Brock I , Connley D et al (2018) . Clinical Chemistry, 64(9), 1338-1346.
Zhao A, Maple L, Jiang J, Myers KN, Jones CG, Gagg H, McGarrity-Cottrell C, Rominiyi O, Collis SJ, Wells G , Rahman M et al () . Cell Death & Disease, 15(12).

Conference proceedings papers

Rahman MM, Wells G, Rantala J, Helleday T, Muthana M & Danson S (2023) . Annals of Oncology, Vol. 34 (pp S1177-S1177)
Gagg H, Williams S, Rominiyi O, Danson S, Collis S & Wells G (2023) . Neuro-Oncology, Vol. 25(Supplement_3) (pp iii5-iii6)
Gagg H, Williams S, Allen R, Conroy S, Rominiyi O, Wells G, Rantala J, Danson S, Helleday T & Collis S (2022) . Brain Tumor Research and Treatment, Vol. 10(Suppl) (pp s240). Seoul, Korea, 24 March 2022 - 24 March 2022.
Wells G, Kohlmann A, Ratcliffe M, Wilson G, Dalton A & Danson S (2018) . European Journal of Surgical Oncology, Vol. 44 (pp S36-S36)
Wells G, Kohlmann A, Ratcliffe M, Wilson G, Dalton A & Danson S (2017) . European Journal of Surgical Oncology, Vol. 43(11) (pp 2233-2233)

Presentations

Wells G Utilising ex vivo imaging to measure drug action at the single cell level using a live biopsy. Nottingham.
Wells G Ex vivo Determined Cancer Therapy. 91ֱ��.

Research group

Prof Sarah Danson (Clinical Lead)
Dr Hannah Gagg (Postdoctoral Research Associate)
Dr Jamie Adams (Postdoctoral Research Associate / Image Specialist)
Dr Nikita Lad (Postdoctoral Research Associate)
Dr Alberto Biancardi (Image Computing Staff Scientist)
Ms Helen Shulver (Senior Research Technician, QA)
Dr Rachel Turner (Research Technician)
Ms Angela Green (Senior Research Nurse)
Ms Vicky Hallworth (Senior Research Nurse)
Ms Sarah Clarke (Clinical Trials Assistant)
Dr Md Marufur Rahman (Clinical PhD Student)
Ms Miriam Arrulo (PhD Student)
Mr Louis Lane (PhD Student)
Mr Callum Blee (PhD Student)

Grants

Yorkshire Cancer Research Programme Award
Western Park Cancer Charity
LifeArc
Medical Research Council

Teaching activities

Msc – Cancer Biology and Therapeutics
MSc - Molecular Medicine