Dr Elizabeth Helen Kemp
BSc (Hons), PhD
Clinical Medicine, School of Medicine and Population Health
Research Fellow in Endocrinology
+44 114 215 9203
Full contact details
Clinical Medicine, School of Medicine and Population Health
EU10
The Medical School
Beech Hill Road
91直播
S10 2RX
- Profile
-
For enquiries, please contact - ClinMed-Operational@sheffield.ac.uk
I joined the University of 91直播 in 1988 after a PhD in Microbiology at the University of Warwick and the Centre for Applied Microbiology and Research, Salisbury. After postdoctoral research in the Department of Molecular Biology and Biotechnology (with Dr Anne Moir), I moved to the Medical School to take up a research position with Professor Tony Weetman. Currently, I am a Research Fellow based in the Department of Oncology and Metabolism in the endocrinology theme.
Current PhD Opportunities:
- Research interests
-
Autoimmune vitiligo: I have a long-standing interest in the autoimmune and genetic aspects of the depigmenting disease vitiligo along with Professor Tony Weetman and Professor David Gawkrodger (University of 91直播). Current collaborators include: Dr Rosalie Luiten (University of Amsterdam, The Netherlands), Dr Vandana Pradhan (National Institute of Immunohaematology, India), and Dr Andrew McDonagh (91直播 Teaching Hospitals) on projects to profile autoantibody responses against melanocytes in melanoma, vitiligo and alopecia areata, respectively. I am a collaborator in The VitGene Consortium, headed by Professor Richard Spritz (University of Colorado, USA) and funded by the National Institutes of Health, which has identified several novel vitiligo-susceptibility genes.
Autoimmune parathyroid disease and autoimmune polyendocrine syndromes: I am interested in characterising autoimmune responses against the calcium-sensing receptor in patients with parathyroid autoimmunity. Current collaborators include: Professor Ed Brown (Harvard Medical School, USA), Professor Kai Krohn (Clinical Research Institute HUCH Ltd., Helsinki, Finland), Professor Eystein Husebye (University of Bergen), and Professor George Kahaly (Johannes Gutenberg University Medical Center, Germany).
Autoimmune thyroid disease: I am interested in the aetiology of autoimmune thyroid disease and, with Professor Tony Weetman and Dr Phil Watson (University of 91直播), have characterised autoantigens, autoantibodies, cytokine gene expression, and genetic susceptibility factors.
Cushing鈥檚 disease: I am interested in the potential of siRNA technology and antisense oligonucleotides as treatments for Cushing鈥檚 disease. Current collaborators are: Professor John Newell-Price and Professor Richard Ross.
Current Projects
- Characterisation of autoantigens and autoantibody responses in vitiligo.
- Genome-wide association study to identify genetic susceptibility factors in vitiligo.
- Characterisation of calcium-sensing receptor autoantibody responses in autoimmune parathyroid disease.
- Identification of autoantibody responses in melanoma patients.
- Identification of melanocyte autoantigens in alopecia areata.
- Investigation of siRNA and antisense oligonucleotides as treatments for Cushing鈥檚 disease.
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- . The Journal of Clinical Endocrinology & Metabolism.
- . Heliyon, 8(8).
- . Journal of Bone and Mineral Research.
- . Clinical and Experimental Immunology.
- . Journal of Investigative Dermatology.
- . Journal of Pediatric Endocrinology and Metabolism.
- . Journal of the European Academy of Dermatology and Venereology.
- . Journal for ImmunoTherapy of Cancer, 8(1).
- . Journal of Clinical Endocrinology and Metabolism.
- . Endocrine, 69(2), 402-409.
- . The Journal of Clinical Endocrinology & Metabolism, 105(7), 2229-2236.
- . The Journal of Clinical Endocrinology & Metabolism, 105(5), 1581-1588.
- . The Journal of Clinical Endocrinology & Metabolism, 104(2), 550-556.
- . Clinical Endocrinology, 90(1), 214-221.
- . The Journal of Immunology, 201(11), 3175-3183.
- . Case Reports in Endocrinology, 2018, 1-4.
- . Clinical Endocrinology, 88(5), 744-751.
- . OncoImmunology, 7(4), e1419113-e1419113.
- . Clinical Endocrinology, 88(1), 139-145.
- . Journal of Immunology Research, 2017, 1-2.
- . Nature Genetics, 48(11), 1418-1424.
- . The Journal of Clinical Endocrinology & Metabolism, 101(8), 3045-3053.
- . Autoimmunity Reviews, 15(4), 379-392.
- . Clinical Endocrinology, 83(5), 726-732.
- . Scandinavian Journal of Rheumatology, 44(5), 425-427.
- . Autoimmunity, 48(8), 532-541.
- . Clinical Case Reports, 3(10), 809-813.
- . Immunity, 42(6), 1185-1196.
- . Journal of Allergy and Clinical Immunology, 135(6), 1578-1588.e5.
- . Autoimmunity Reviews, 14(1), 49-56.
- . Gene, 549(2), 286-294.
- . Clinical Endocrinology, 81(3), 440-444.
- . The Journal of Clinical Endocrinology & Metabolism, 99(3), 1064-1071.
- . Pigment Cell & Melanoma Research, 27(6), 1086-1096.
- . Thyroid, 24(2), 371-382.
- . British Journal of Dermatology, 168(6), 1195-1204.
- . Journal of the European Academy of Dermatology and Venereology, 27(3), 279-286.
- . British Journal of Dermatology, 168(4), 733-738.
- . The Journal of Clinical Endocrinology & Metabolism, 98(2), E309-E313.
- . American Journal of Kidney Diseases, 62(6), 1151-1154.
- . International Journal of Immunopathology and Pharmacology, 26(1), 217-222.
- . Journal of the European Academy of Dermatology and Venereology, 27(9), 1172-1175.
- . British Journal of Dermatology, 167(1), 17-28.
- . Nature Genetics, 44(6), 676-680.
- . British Journal of Dermatology, 165(6), 1236-1243.
- . Rheumatology, 50(6), 1173-1175.
- . The Journal of Clinical Endocrinology & Metabolism, 96(3), 672-680.
- . Journal of Investigative Dermatology, 131(2), 371-381.
- . Journal of Investigative Dermatology, 131(6), 1308-1312.
- . Experimental Dermatology, 20(1), 35-40.
- . Nature Genetics, 42(7), 576-578.
- . New England Journal of Medicine, 362(18), 1686-1697.
- . Journal of Investigative Dermatology, 130(1), 230-240.
- . Journal of Bone and Mineral Research, 25(1), 132-140.
- . The Journal of Clinical Endocrinology & Metabolism, 94(12), 4749-4756.
- . Peptides, 30(11), 2071-2075.
- . Experimental Dermatology, 18(5), 454-463.
- . Nephrology Dialysis and Transplantation, 24(2), 686-688.
- . European Journal of Human Genetics, 16(8), 977-982.
- . Experimental Dermatology, 17(2), 139-160.
- . Experimental Dermatology, 17(2), 139-140.
- Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Commentary 1. Experimental Dermatology, 17(2), 150-151.
- The aetiology and pathogenesis of vitiligo: The role of immunological factors. Current Trends in Immunology, 8, 87-101.
- . Journal of European Academy of Dermatology and Venereology, 21(7), 865-876.
- . Journal of Clinical Endocrinology and Metabolism, 92(6), 2107-2114.
- . Tissue Engineering, 13(5), 1013-1024.
- . Autoimmun Reviews, 6(3), 138-142.
- . Endocrinology, 147(12), 5995-6003.
- . Laboratory Investigation, 86(8), 781-789.
- . Biochemical and Biophysical Research Communications, 345(4), 1586-1591.
- . Human Immunology, 67(7), 535-539.
- . Genes and Immunity, 6(7), 584-587.
- . Arch Dermatol Res, 297(2), 94-98.
- . Pigment Cell Research, 18(1), 55-58.
- . Autoimmunity, 37(4), 287-290.
- . J Clin Endocrinol Metab, 89(7), 3474-3476.
- . Br J Cancer, 90(7), 1457-1463.
- . J Invest Dermatol, 122(4), 1010-1019.
- . Br J Cancer, 89(10), 2004-2015.
- . J Invest Dermatol, 121(4), 765-770.
- . Clin Endocrinol (Oxf), 59(2), 207-213.
- . J Clin Pathol, 56(6), 475-477.
- . Biochem Biophys Res Commun, 298(1), 169-177.
- . Clin Exp Immunol, 129(3), 527-532.
- . J Clin Invest, 109(7), 923-930.
- . J Invest Dermatol, 119(6), 1244-1253.
- . Autoimmunity, 34(1), 65-77.
- . Expert Rev Mol Med, 3(20), 1-22.
- . Clin Exp Immunol, 124(3), 509-515.
- . Clin Exp Immunol, 124(3), 377-385.
- . J Biol Chem, 276(38), 35390-35395.
- . Br J Cancer, 85(6), 875-880.
- . J Bacteriol, 183(14), 4317-4322.
- . Clin Endocrinol (Oxf), 53(3), 291-299.
- . J Clin Endocrinol Metab, 85(5), 2020-2027.
- . J Clin Endocrinol Metab, 85(2), 688-691.
- . Br J Dermatol, 140(1), 73-78.
- . J Invest Dermatol, 113(2), 267-271.
- . Br J Dermatol, 139(5), 798-805.
- . Clin Exp Immunol, 114(3), 333-338.
- . Clin Endocrinol (Oxf), 49(5), 609-613.
- . Clin Exp Immunol, 109(3), 495-500.
- . J Clin Endocrinol Metab, 82(8), 2639-2644.
- . J Clin Endocrinol Metab, 82(11), 3818-3825.
- . J Invest Dermatol, 109(1), 69-73.
- Cloning and analysis of IgG kappa and IgG lambda anti-thyroglobulin autoantibodies from a patient with Hashimoto's thyroiditis: evidence for in vivo antigen-driven repertoire selection.. J Immunol, 157(2), 927-935.
- . J Bacteriol, 173(15), 4646-4652.
- . Res Microbiol, 142(7-8), 847-850.
- Complete nucleotide sequence and deduced amino acid sequence of the M5 polypeptide gene of Escherichia coli K12. Nucleic Acids Res, 15, 3924-3924.
- . Biotechnology and Bioengineering, 106(5), 794-803.
Chapters
- , Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases (pp. 189-223). Springer Nature Singapore
- Autoimmune hypoparathyroidism In Brandi ML & Brown EM (Ed.), Hypoparathyroidism (pp. 177-188). Milan, Italy: Springer-Verlag Italia.
- In Chatzidionysiou K (Ed.), Autoimmune Diseases - Pathogenesis, Clinical Aspects and Therapy of Specific Autoimmune Diseases (pp. 153-173). Rijeka, Croatia: InTech.
- Autoimmunity in vitiligo In Mavragani C (Ed.), Autoimmune Disorders - Pathogenic Aspects (pp. 271-294). Rijeka, Croatia: InTech.
- Humoral immunity In Picardo M & Ta茂eb A (Ed.), Vitiligo (pp. 248-256). Heidelberg, Germany: Springer.
- Cytotoxic T lymphocyte antigen-4 in autoimmune thyroid disease and vitiligo In Pociot F (Ed.), CTLA-4 in Autoimmune Disease (pp. 45-54). Austin, Texas, USA: Eurekah.Com Inc.
- Orbital autoantigens In Bahn RS (Ed.), Thyroid Eye Disease (pp. 1-20). Dordrecht, The Netherlands: Springer.
All publications
Books
Journal articles
- . The Journal of Clinical Endocrinology & Metabolism.
- Preface. Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases: Volume II: Kidney, Central Nervous System, Eye, Blood, Blood Vessels and Bowel, 2, vii.
- . Heliyon, 8(8).
- . Journal of Bone and Mineral Research.
- . Clinical and Experimental Immunology.
- , xix-xix.
- Preface. Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases: Volume I: Liver, Skin, Thyroid, Rheumatic and Myopathic Diseases, xi.
- . Journal of Investigative Dermatology.
- . Journal of the Endocrine Society, 5(Suppl 1), a532-a533.
- .
- . Journal of Pediatric Endocrinology and Metabolism.
- . Journal of the European Academy of Dermatology and Venereology.
- . Journal for ImmunoTherapy of Cancer, 8(1).
- . Journal of Clinical Endocrinology and Metabolism.
- . Endocrine, 69(2), 402-409.
- . The Journal of Clinical Endocrinology & Metabolism, 105(7), 2229-2236.
- . The Journal of Clinical Endocrinology & Metabolism, 105(5), 1581-1588.
- . Journal of the Endocrine Society, 3(Supplement_1).
- . The Journal of Clinical Endocrinology & Metabolism, 104(2), 550-556.
- . Clinical Endocrinology, 90(1), 214-221.
- . The Journal of Immunology, 201(11), 3175-3183.
- . Case Reports in Endocrinology, 2018, 1-4.
- . Clinical Endocrinology, 88(5), 744-751.
- . OncoImmunology, 7(4), e1419113-e1419113.
- . Clinical Endocrinology, 88(1), 139-145.
- . Journal of Immunology Research, 2017, 1-2.
- . Nature Genetics, 48(11), 1418-1424.
- . The Journal of Clinical Endocrinology & Metabolism, 101(8), 3045-3053.
- . Autoimmunity Reviews, 15(4), 379-392.
- . Clinical Endocrinology, 83(5), 726-732.
- . Scandinavian Journal of Rheumatology, 44(5), 425-427.
- . Autoimmunity, 48(8), 532-541.
- . Clinical Case Reports, 3(10), 809-813.
- . Immunity, 42(6), 1185-1196.
- . Journal of Allergy and Clinical Immunology, 135(6), 1578-1588.e5.
- . Autoimmunity Reviews, 14(1), 49-56.
- . Gene, 549(2), 286-294.
- . Clinical Endocrinology, 81(3), 440-444.
- . The Journal of Clinical Endocrinology & Metabolism, 99(3), 1064-1071.
- . Pigment Cell & Melanoma Research, 27(6), 1086-1096.
- . Thyroid, 24(2), 371-382.
- . British Journal of Dermatology, 168(6), 1195-1204.
- . Journal of the European Academy of Dermatology and Venereology, 27(3), 279-286.
- . British Journal of Dermatology, 168(4), 733-738.
- . The Journal of Clinical Endocrinology & Metabolism, 98(2), E309-E313.
- . American Journal of Kidney Diseases, 62(6), 1151-1154.
- . International Journal of Immunopathology and Pharmacology, 26(1), 217-222.
- . Journal of the European Academy of Dermatology and Venereology, 27(9), 1172-1175.
- . British Journal of Dermatology, 167(1), 17-28.
- . Nature Genetics, 44(6), 676-680.
- . British Journal of Dermatology, 165(6), 1236-1243.
- . Rheumatology, 50(6), 1173-1175.
- . The Journal of Clinical Endocrinology & Metabolism, 96(3), 672-680.
- . Journal of Investigative Dermatology, 131(2), 371-381.
- . Journal of Investigative Dermatology, 131(6), 1308-1312.
- . Experimental Dermatology, 20(1), 35-40.
- . Nature Genetics, 42(7), 576-578.
- . New England Journal of Medicine, 362(18), 1686-1697.
- . Journal of Investigative Dermatology, 130(1), 230-240.
- . Journal of Bone and Mineral Research, 25(1), 132-140.
- . The Journal of Clinical Endocrinology & Metabolism, 94(12), 4749-4756.
- . Peptides, 30(11), 2071-2075.
- . Experimental Dermatology, 18(5), 454-463.
- . Nephrology Dialysis and Transplantation, 24(2), 686-688.
- . European Journal of Human Genetics, 16(8), 977-982.
- . Experimental Dermatology, 17(2), 139-160.
- . Experimental Dermatology, 17(2), 139-140.
- Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Commentary 1. Experimental Dermatology, 17(2), 150-151.
- . Experimental Dermatology, 17(2), 150-151.
- The aetiology and pathogenesis of vitiligo: The role of immunological factors. Current Trends in Immunology, 8, 87-101.
- . Journal of European Academy of Dermatology and Venereology, 21(7), 865-876.
- . Journal of Clinical Endocrinology and Metabolism, 92(6), 2107-2114.
- . Tissue Engineering, 13(5), 1013-1024.
- . Autoimmun Reviews, 6(3), 138-142.
- . Endocrinology, 147(12), 5995-6003.
- . Laboratory Investigation, 86(8), 781-789.
- . Biochemical and Biophysical Research Communications, 345(4), 1586-1591.
- . Human Immunology, 67(7), 535-539.
- . Genes and Immunity, 6(7), 584-587.
- . Arch Dermatol Res, 297(2), 94-98.
- . Pigment Cell Research, 18(1), 55-58.
- . Autoimmunity, 37(4), 287-290.
- . J Clin Endocrinol Metab, 89(7), 3474-3476.
- . Br J Cancer, 90(7), 1457-1463.
- . J Invest Dermatol, 122(4), 1010-1019.
- . Br J Cancer, 89(10), 2004-2015.
- . J Invest Dermatol, 121(4), 765-770.
- . Clin Endocrinol (Oxf), 59(2), 207-213.
- . J Clin Pathol, 56(6), 475-477.
- . Biochem Biophys Res Commun, 298(1), 169-177.
- . Clin Exp Immunol, 129(3), 527-532.
- . J Clin Invest, 109(7), 923-930.
- . J Invest Dermatol, 119(6), 1244-1253.
- . Autoimmunity, 34(1), 65-77.
- . Expert Rev Mol Med, 3(20), 1-22.
- . Clin Exp Immunol, 124(3), 509-515.
- . Clin Exp Immunol, 124(3), 377-385.
- . J Biol Chem, 276(38), 35390-35395.
- . Br J Cancer, 85(6), 875-880.
- . J Bacteriol, 183(14), 4317-4322.
- . Clin Endocrinol (Oxf), 53(3), 291-299.
- . J Clin Endocrinol Metab, 85(5), 2020-2027.
- . J Clin Endocrinol Metab, 85(2), 688-691.
- . Br J Dermatol, 140(1), 73-78.
- . J Invest Dermatol, 113(2), 267-271.
- . Br J Dermatol, 139(5), 798-805.
- . Clin Exp Immunol, 114(3), 333-338.
- . Clin Endocrinol (Oxf), 49(5), 609-613.
- . Clin Exp Immunol, 109(3), 495-500.
- . J Clin Endocrinol Metab, 82(8), 2639-2644.
- . J Clin Endocrinol Metab, 82(11), 3818-3825.
- . J Invest Dermatol, 109(1), 69-73.
- Cloning and analysis of IgG kappa and IgG lambda anti-thyroglobulin autoantibodies from a patient with Hashimoto's thyroiditis: evidence for in vivo antigen-driven repertoire selection.. J Immunol, 157(2), 927-935.
- . J Bacteriol, 173(15), 4646-4652.
- . Res Microbiol, 142(7-8), 847-850.
- Complete nucleotide sequence and deduced amino acid sequence of the M5 polypeptide gene of Escherichia coli K12. Nucleic Acids Res, 15, 3924-3924.
- . Biotechnology and Bioengineering, 106(5), 794-803.
Chapters
- , Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases (pp. 189-223). Springer Nature Singapore
- , Probiotics in the Prevention and Management of Human Diseases (pp. xix). Elsevier
- Autoimmune hypoparathyroidism In Brandi ML & Brown EM (Ed.), Hypoparathyroidism (pp. 177-188). Milan, Italy: Springer-Verlag Italia.
- In Chatzidionysiou K (Ed.), Autoimmune Diseases - Pathogenesis, Clinical Aspects and Therapy of Specific Autoimmune Diseases (pp. 153-173). Rijeka, Croatia: InTech.
- Autoimmunity in vitiligo In Mavragani C (Ed.), Autoimmune Disorders - Pathogenic Aspects (pp. 271-294). Rijeka, Croatia: InTech.
- Humoral immunity In Picardo M & Ta茂eb A (Ed.), Vitiligo (pp. 248-256). Heidelberg, Germany: Springer.
- Cytotoxic T lymphocyte antigen-4 in autoimmune thyroid disease and vitiligo In Pociot F (Ed.), CTLA-4 in Autoimmune Disease (pp. 45-54). Austin, Texas, USA: Eurekah.Com Inc.
- Orbital autoantigens In Bahn RS (Ed.), Thyroid Eye Disease (pp. 1-20). Dordrecht, The Netherlands: Springer.
Conference proceedings papers
- Immunophenotypic analysis reveals differences in circulating immune cells in peripheral blood of segmental and non-segmental vitiligo patients. EUROPEAN JOURNAL OF IMMUNOLOGY, Vol. 51 (pp 355-355)
- The genetic analysis of bacterial spore germination.. J Appl Bacteriol, Vol. 77(3) (pp 9S-16S). England
Reports
- Teaching activities
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I am primary supervisor of MD, PhD, and intercalating students. I contribute to the MSc in Molecular Medicine and the MBChB degree course
- Professional activities and memberships
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British Journal of Dermatology, Section Editor, 2007-2014.
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Dermatology Research and Practice, Editorial Board, 2010-2021.
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Journal of Dermatological Research, Editorial Board, 2016-present.
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Antibodies, Editorial Board, 2020-present.
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Vitiligo Society Scientific and Medical Advisory Board Member, 2018-2021.
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UK Translational Research Network in Dermatology (UK TREND), Member, 2014-present.
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British Skin Foundation Large Grants Advisory Committee, 2010-2014.
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British Skin Foundation Small Grants Advisory Committee, 2020-2022.
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European Cooperation in Science and Technology (COST) Grants, External Expert Panel Member, 2012.
Member of Learned Societies:
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British Society for Immunology
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British Society for Investigative Dermatology
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European Society for Dermatological Research
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Society for Endocrinology
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European Society for Pigment Cell Research
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Royal Society of Biology
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European Society of Endocrinology
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Endocrine Society
-