Professor Christopher Newman
MA, PhD, FRCP
Clinical Medicine, School of Medicine and Population Health
Professor of Clinical Cardiology
Honorary Consultant Cardiologist
Full contact details
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
91直播
S10 2RX
- Profile
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For enquiries, contact ClinMed-Operational@sheffield.ac.uk
I joined the University in 1995 following an MRC Clinician Scientist Fellowship spent at the National Institute for Medical Research and Royal Postgraduate Medical School (1989-1992) and the University of Cambridge (1992-1995).
I was appointed as Director of the Clinical Research Facility in 2004, a joint initiative between the University and 91直播 Teaching Hospitals NHS Foundation Trust.
The NIHR 91直播 CRF has units both at the Royal Hallamshire Hospital and Northern General Hospital.
- Research interests
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My main research interest is in non-viral gene delivery, particularly the use of high frequency ultrasound to promote plasmid-mediated vascular gene delivery.
I also have interests in site specific targeting of gene therapy vectors, the vascular biology of pulmonary hypertension, the pathophysiology of sudden death in young diabetics, new approaches to the analysis of gene expression in acute coronary syndromes and links between the pathobiology of osteoporosis and cardiovascular disease.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
All publications
Journal articles
- . Nature Communications, 10(1).
- . Bone, 69, 1-5.
- . J Exp Med, 209(11), 1919-1935.
- . Pulm Circ, 2(1), 21-27.
- . Trends in Endocrinology & Metabolism, 23(4), 163-168.
- . Archives of Biochemistry and Biophysics, 503(1), 78-83.
- . Europace, 12(4), 553-560.
- . J Gene Med, 11(4), 326-334.
- . The American Journal of Pathology, 172(1), 256-264.
- The effects of ultrasound on polymer-mediated gene transfer in vitro. INTERNATIONAL JOURNAL OF CARDIOLOGY, 122, 49-50.
- . Gene Ther, 14(6), 465-475.
- . Heart, 93, 251-252.
- . Eur J Clin Pharmacol, 61(10), 733-742.
- . Gene Ther, 12(14), 1154-1157.
- . J Gene Med, 7(3), 375-385.
- . Diabetes, 53(6), 1535-1542.
- . Ultrasound Med Biol, 29(10), 1453-1461.
- . Expert Reviews in Molecular Medicine, 5(22), 1-15.
- . The Annals of Thoracic Surgery, 76(3), 959-966.
- National audit of myocardial infarction project. Journal of Clinical Excellence, 4(4), 375.
- . Diabetes, 52(6), 1469-1474.
- . Heart, 89(2), 127-131.
- . Clinical Science, 103(s47), 14P-14P.
- . BMJ, 324(7339), 709-709.
- . Clin Endocrinol (Oxf), 56(1), 33-38.
- . Echocardiography, 18(4), 339-347.
- . Gene Ther, 7(23), 2023-2027.
- Small stent, small vessel is not equivalent to standard stent, standard vessel.. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 42I-42I.
- Effects of arterial taper upon in-stent restenosis in very small coronary vessels.. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 117I-117I.
- Are we achieving intended dimensions in stenting very small coronary arteries?. AMERICAN JOURNAL OF CARDIOLOGY, 86(8A), 42I-42I.
- Mammalian suppressor of sgv-1 (MSS1), a putative transcription factor and differentiation related gene, is upregulated in explant derived compared with enzyme dispersed human aortic vascular smooth muscle cells in vitro. J AM COLL CARDIOL, 35(2), 49A-49A.
- . Circulation, 99(20), 2617-2620.
- . Methods Mol Med, 30, 39-46.
- . Heart, 80(5), 509-516.
- Overlapping stents: No alteration in neointima formation.. CIRCULATION, 98(17), 189-189.
- . Circulation, 98(16), 1657-1665.
- Aorto-ostial stent: Procedural, angiographic and histological evaluation in porcine coronary arteries.. AMERICAN JOURNAL OF CARDIOLOGY, 82(7A), 68S-68S.
- Assessment of the safety and efficacy of supersaturated oxygen solution: A novel method of reducing myocardial ischaemia in PTCA.. AMERICAN JOURNAL OF CARDIOLOGY, 82(7A), 100S-100S.
- 1MHz ultrasound enhances transfection of porcine aortic endothelial cells in vitro and oligonucleotide uptake in an organ culture model.. AM J CARDIOL, 82(7A), 29S-29S.
- . Journal of the American College of Cardiology, 31(2), 22A-22A.
- . Journal of the American College of Cardiology, 31(2), 414A-414A.
- Nigh frequency ultrasound enhances transfection of porcine vascular smooth muscle cells in vitro. J AM COLL CARDIOL, 31(2), 25A-25A.
- . Heart, 79(2), 121-127.
- The BioDivYsio(R) stent: Morphometric superiority to the Palmaz-Schatz stent in the porcine coronary model. AMERICAN JOURNAL OF CARDIOLOGY, 80, TCT95-TCT95.
- . Tetrahedron Letters, 38(14), 2569-2572.
- . Circ Res, 80(4), 520-531.
- In-stent restenosis: More metal and more symmetry required?. Heart, 77(SUPPL. 1).
- . Arteriosclerosis, Thrombosis, and Vascular Biology, 15, 2010-2018.
- . Biochemical and Biophysical Research Communications, 192(3), 983-990.
- . Regulatory Peptides, 44(1), 61-69.
- A novel N-terminal motif for palmitoylation of G-protein alpha subunits. Biochem J, 291 ( Pt 2), 349-353.
- Post-translational processing of Schizosaccharomyces pombe YPT5 protein. In vitro and in vivo analysis of processing mutants. Journal of Biological Chemistry, 268, 24467-24474.
- Inhibition in the rat of nitric oxide synthesis in vivo does not attenuate the hypotensive action of acetylcholine, ATP or bradykinin. Experimental Physiology, 77, 285-292.
- Post-translational processing of Schizosaccharomyces pombe YPT proteins. Journal of Biological Chemistry, 267, 11329-11336.
- Response of angiographically normal and atherosclerotic left anterior descending coronary arteries to acetylcholine. Am J Cardiol, 66, 1070-1076.
- Rapid tolerance to the hypotensive effects of glyceryl trinitrate in the rat: prevention by N-acetyl-L- but not N-acetyl-D-cysteine. Br J Pharmacol, 99, 825-829.
- Cardiac catheterization as an outpatient procedure. BMJ, 298, 1310.
- Enalapril for severe heart failure in infancy. Arch Dis Child, 64, 219-223.
- The importance of bradykinin and histamine in the skin response to antigen. Br J Clin Pharmacol, 26, 803-805.
Conference proceedings papers
- . The Lancet, Vol. 381 (pp S47-S47)
- . Heart, Vol. 98(Suppl 3) (pp A1.3-A1)
- TYPE I COLLAGEN DEGRADATION DURING TISSUE REPAIR: COMPARISON OF MECHANISMS FOLLOWING FRACTURE AND MYOCARDIAL INFARCTION. OSTEOPOROSIS INTERNATIONAL, Vol. 23 (pp S580-S581)
- . Bone, Vol. 50 (pp S119-S119)
- . D97. PULMONARY HYPERTENSION: NEW INSIGHTS INTO CAUSES AND TREATMENTS?
- . Thorax, Vol. 66(Suppl 4) (pp A34-A34)
- . Thorax, Vol. 66(Suppl 4) (pp A3-A3)
- . B61. PULMONARY HYPERTENSION: EXPERIMENTAL MODELS I
- . Thorax, Vol. 65(Suppl 4) (pp A68-A68)
- . THORAX, Vol. 64 (pp A8-A8)
- . THORAX, Vol. 64 (pp A58-A59)
- . THORAX, Vol. 64 (pp A9-A9)
- . THORAX, Vol. 64 (pp A9-A9)
- OPG:TRAIL Ratio as a Potential Biomarker for Pulmonary Arterial Hypertension. CIRCULATION, Vol. 120(18) (pp S806-S806)
- Investigating Cardiac Autonomic Neuropathy and Sudden Death. The Effect of Neuropathy on Abnormal Cardiac Repolarisation during Sympatho-Adrenal Activation in Type 1 Diabetes. DIABETES, Vol. 58 (pp A170-A170)
- THE OSTEOPROTEGERIN-TNF-RELATED APOPTOSIS-INDUCING LIGAND AXIS IN PULMONARY ARTERIAL HYPERTENSION. THORAX, Vol. 63 (pp A28-A28)
- A potential role for TRAIL in the pathogenesis of pulmonary arterial hypertension. CIRCULATION, Vol. 116(16) (pp 59-59)
- A potential role for osteoprotegerin in idiopathic pulmonary arterial hypertension. HEART, Vol. 93 (pp A23-A24)
- . Vascular Pharmacology, Vol. 45(3) (pp e106-e106)
- The impact of a policy of selective drug eluting stent implantation upon clinical resteosis: A 'real world' registry. HEART, Vol. 92 (pp A98-A98)
- Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model. CIRCULATION, Vol. 110(17) (pp 161-161)
- Adjunctive ultrasound exposure enhances gene delivery to vascular smooth muscle cells in vitro and to ex vivo and in vivo porcine saphenous vein grafts. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 92(6A) (pp 100L-100L)
- Modulation of non-viral vascular gene delivery by VP22-mediated intercellular protein transport. ATHEROSCLEROSIS, Vol. 169(1) (pp 200-201)
- Enhancing the effective efficiency of non-viral vascular gene transfer by intercellular trafficking of VP22 fusion proteins. HEART, Vol. 89 (pp A16-A16)
- Highly efficient bystander effect and intercellular trafficking of VP22-tghymidine kinase fusion proteins following non-viral transfection in vascular cells. CIRCULATION, Vol. 106(19) (pp 269-269)
- Drug-eluting stents: Maximizing benefit and minimizing costs.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 71H-71H)
- Endoluminal ultrasound enhances nonviral gene delivery from plasmid-coated stents.. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 90(6A) (pp 118H-119H)
- Modulation of MSS1, a component of the 26S proteasome, in vascular smooth muscle cells in vitro and following experimental PTCA. EUROPEAN HEART JOURNAL, Vol. 22 (pp 3-3)
- Ultrasound-enhanced reporter gene expression following naked DNA transfection is markedly enhanced by the presence of microbubble contrast agents.. AM J CARDIOL, Vol. 84(6A) (pp 64P-65P)
- . Journal of the American College of Cardiology, Vol. 31 (pp 25-25)
- Is local drug delivery truly a low efficiency procedure?. AMERICAN JOURNAL OF CARDIOLOGY, Vol. 80 (pp TC240-TC240)
- Teaching activities
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I organise and deliver teaching within modules of the undergraduate medical student curriculum. I teach on courses related to the ethics and governance of clinical research.