Streets, Andrew, Dr

Dr Andrew Streets

BSc MSc PhD

Clinical Medicine, School of Medicine and Population Health

Research Fellow in Nephrology

a.j.streets@sheffield.ac.uk
+44 114 215 9555

The Medical School

Full contact details

Dr Andrew Streets
Clinical Medicine, School of Medicine and Population Health
The Medical School
Beech Hill Road
91ֱ��
S10 2RX

Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

I obtained a BSc (Hons) from the University of Durham in 1993, an MSc from UCL in 1996 and completed my PhD at the University of Leeds in 2000. I joined the University of 91ֱ�� in 1999 working in the Kidney Genetics Group headed by Professor Albert Ong.

After completing a Kidney Research UK Career Development Fellowship I was awarded an RCUK Academic Fellowship in 2006 with support from the 91ֱ�� Kidney Research Foundation. I currently hold the title of Senior Research Fellow in Nephrology.

Research interests

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic disease affecting the kidney (incidence 1 in 1000) and is caused by mutations in two genes, PKD1 (85-90%) or PKD2 (10-15%) which encode the polycystin-1 and 2 proteins respectively.

Around 10% of patients on renal replacement therapy have ADPKD and it is estimated that this treatment costs £40 million per annum to the NHS alone. There are currently no effective drugs for slowing progression in the 50% of ADPKD patients who are destined to develop end-stage renal failure.

The aim of my current research is to test the hypothesis that the biology of the polycystin-1 and 2 complex is regulated by reversible protein phosphorylation under the control of tightly regulated protein kinases and phosphatases. Reversible phosphorylation regulates protein trafficking, protein-protein interactions and protein functions such as cell-cell adhesion, channel activity and cell signalling. Polycystin-1 and 2 can act either as part of a complex, or as individual proteins to carry out these functions.

Understanding this dynamic process will provide important new information which could lead to new treatments to retard cyst formation in ADPKD. My recent work has shown that phosphorylation plays a key role in regulating polycystin-2 function both in vitro and in vivo and that polycystin-1 regulates cell adhesion, both of which are critically important for the maintenance of normal tubular and glomerular morphology.

I also have a keen interest in the role of microRNAs in ADPKD. We and others have shown that alterations in miRNA may contribute to the pathogenesis of ADPKD as well as acting as novel biomarkers. We have carried out microarrays as well as Next Generation Sequencing to identify changes in miRNAs in ADPKD. My work aims to understand the function of these dysregulated miRNAs in ADPKD.

Current projects

My research has been funded by the RCUK, KRUK, SKRF, ERA-EDTA and the Northern General Hospital trustees as well as the Medical School.

My current projects include:

The role of phosphorylation in the regulation of polycystin-2 function.
The role of polycystin 1 and 2 in the regulation of cell adhesion.
The role of microRNAs in the pathogenesis of ADPKD.
Trafficking of the polycystin proteins.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Xu Y, Streets AJ, Hounslow AM, Tran U, Jean-Alphonse F, Needham AJ, Vilardaga J-P, Wessely O, Williamson MP & Ong ACM (2016) . Journal of the American Society of Nephrology, 27(4), 1159-1173.
Cantero MDR, Velázquez IF, Streets AJ, Ong ACM & Cantiello HF (2015) . Journal of Biological Chemistry, 290(39), 23888-23896.
Streets AJ, Wessely O, Peters DJM & Ong ACM (2013) . Hum Mol Genet, 22(10), 1924-1939.
Chou C-Y, Streets AJ, Watson PF, Huang L, Verderio EAM & Johnson TS (2011) . J Biol Chem, 286(31), 27825-27835.
Mao Z, Streets AJ & Ong ACM (2011) . Am J Physiol Renal Physiol, 300(6), F1375-F1384.
Streets AJ, Needham AJ, Gill SK & Ong ACM (2010) . Mol Biol Cell, 21(22), 3853-3865.
Streets AJ, Wagner BE, Harris PC, Ward CJ & Ong ACM (2009) . J Cell Sci, 122(Pt 9), 1410-1417.
Feng S, Okenka GM, Bai C-X, Streets AJ, Newby LJ, DeChant BT, Tsiokas L, Obara T & Ong ACM (2008) . J Biol Chem, 283(42), 28471-28479.
Bai CX, Kim S, Li WP, Streets AJ, Ong AC & Tsiokas L (2008) . EMBO J, 27(9), 1345-1356.
Parker E, Newby LJ, Sharpe CC, Rossetti S, Streets AJ, Harris PC, O'Hare MJ & Ong ACM (2007) . Kidney Int, 72(2), 157-165.
Streets AJ, Moon DJ, Kane ME, Obara T & Ong ACM (2006) . Hum Mol Genet, 15(9), 1465-1473.
Streets AJ, Newby LJ, O'Hare MJ, Bukanov NO, Ibraghimov-Beskrovnaya O & Ong ACM (2003) . J Am Soc Nephrol, 14(7), 1804-1815.
Streets AJ, Ibraghimov-Beskrovnaya O & Ong ACM (2002) Polycystin-1 mediates cell-cell adhesion in PKD1 transgenic and non-transgenic lines. J AM SOC NEPHROL, 13, 46A-46A.
Newby LJ, Streets AJ, Zhao Y, Harris PC, Ward CJ & Ong ACM (2002) . J Biol Chem, 277(23), 20763-20773.

All publications

Journal articles

Ong A, Valluru M, Streets A & Smith D (2024) . Nephrology Dialysis Transplantation, 39(Supplement_1).
Streets A & Ong A (2020) . Cellular Signalling, 72, 109644-109644.
Lannoy M, Valluru MK, Chang L, Abdela-Ali F, Peters DJM, Streets AJ & Ong ACM (2020) . Kidney International.
Magayr TA, Song X, Streets AJ, Vergoz L, Chang L, Valluru MK, Yap HL, Lannoy M, Haghighi A, Simms RJ , Tam FWK et al (2020) . Kidney International.
Metzner A, Griffiths JD, Streets AJ, Markham E, Philippou T, Van Eeden FJM & Ong ACM (2020) . Scientific Reports, 10(1).
Feng S, Streets AJ, Nesin V, Tran U, Nie H, Onopiuk M, Wessely O, Tsiokas L & Ong A (2017) . Journal of the American Society of Nephrology : JASN, 28(10), 2973-2984.
Streets AJ, Magayr TA, Huang L, Vergoz L, Rossetti S, Simms RJ, Harris PC, Peters DJM & Ong ACM (2017) . American Journal of Physiology - Renal Physiology, 312(4), F577-F588.
Lannoy M, Abdela-ali F, Streets AJ & Ong ACM (2016) . Nephrology Dialysis Transplantation, 31(suppl_1), i22-i23.
Xu Y, Streets AJ, Hounslow AM, Tran U, Jean-Alphonse F, Needham AJ, Vilardaga J-P, Wessely O, Williamson MP & Ong ACM (2016) . Journal of the American Society of Nephrology, 27(4), 1159-1173.
Cantero MDR, Velázquez IF, Streets AJ, Ong ACM & Cantiello HF (2015) . Journal of Biological Chemistry, 290(39), 23888-23896.
Streets AJ, Xu Y & Ong ACM (2015) . Nephrology Dialysis Transplantation, 30(suppl_3), iii63-iii63.
Streets AJ, Wessely O, Peters DJM & Ong ACM (2013) . Hum Mol Genet, 22(10), 1924-1939.
Chou C-Y, Streets AJ, Watson PF, Huang L, Verderio EAM & Johnson TS (2011) . J Biol Chem, 286(31), 27825-27835.
Mao Z, Streets AJ & Ong ACM (2011) . Am J Physiol Renal Physiol, 300(6), F1375-F1384.
Streets AJ, Needham AJ, Gill SK & Ong ACM (2010) . Mol Biol Cell, 21(22), 3853-3865.
Streets AJ, Wagner BE, Harris PC, Ward CJ & Ong ACM (2009) . J Cell Sci, 122(Pt 9), 1410-1417.
Feng S, Okenka GM, Bai C-X, Streets AJ, Newby LJ, DeChant BT, Tsiokas L, Obara T & Ong ACM (2008) . J Biol Chem, 283(42), 28471-28479.
Bai CX, Kim S, Li WP, Streets AJ, Ong AC & Tsiokas L (2008) . EMBO J, 27(9), 1345-1356.
Parker E, Newby LJ, Sharpe CC, Rossetti S, Streets AJ, Harris PC, O'Hare MJ & Ong ACM (2007) . Kidney Int, 72(2), 157-165.
Streets AJ, Moon DJ, Kane ME, Obara T & Ong ACM (2006) . Hum Mol Genet, 15(9), 1465-1473.
Streets AJ, Newby LJ, O'Hare MJ, Bukanov NO, Ibraghimov-Beskrovnaya O & Ong ACM (2003) . J Am Soc Nephrol, 14(7), 1804-1815.
Streets AJ, Ibraghimov-Beskrovnaya O & Ong ACM (2002) Polycystin-1 mediates cell-cell adhesion in PKD1 transgenic and non-transgenic lines. J AM SOC NEPHROL, 13, 46A-46A.
Newby LJ, Streets AJ, Zhao Y, Harris PC, Ward CJ & Ong ACM (2002) . J Biol Chem, 277(23), 20763-20773.
Dwek MV, Ross HA, Streets AJ, Brooks SA, Adam E, Titcomb A, Woodside JV, Schumacher U & Leathem AJ (2001) Helix pomatia agglutinin lectin-binding oligosaccharides of aggressive breast cancer. INT J CANCER, 95(2), 79-85.
Baldwin SA, Barros LF, Griffiths M, Ingram J, Robbins EC, Streets AJ & Saklatvala J (1997) . Biochem Soc Trans, 25(3), 954-958.
Dwek MV, Brooks SA, Streets AJ, Harvey DJ & Leathem AJ (1996) . Anal Biochem, 242(1), 8-14.
Streets AJ, Brooks SA, Dwek MV & Leathem AJ (1996) . Clin Chim Acta, 254(1), 47-61.
Harskamp LR, Perez-Gomez MV, Heida JE, Engels GE, van Goor H, van den Heuvel MC, Streets AJ, Ong ACM, Ortiz A, Gansevoort RT , Drenth JPH et al () . Nephrology Dialysis Transplantation.
Streets AJ, Prosseda PP & Ong ACM () . JCI Insight.

Chapters

Streets A & Ong A (2014) , Pathologies of Calcium Channels (pp. 491-522). Springer Berlin Heidelberg

Conference proceedings papers

Magayr T, Streets A & Ong A (2020) . Kidney International Reports, Vol. 5(3) (pp S185-S185). Abu Dhabi, United Arab Emirates, 26 March 2020 - 29 March 2020.
Magayr T, Streets A & Ong A (2019) GLOBAL MICRORNA PROFILING IN HUMAN URINARY EXOSOMES REVEALS NEW DISEASE BIOMARKERS AND CELLULAR PATHWAYS FOR AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD). NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 34
Lannoy M, Abdela-ali F, Streets AJ & Ong ACM (2016) SELECTIVE PROSTAGLANDIN E2 RECEPTOR BLOCKADE FOR THE TREATMENT OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 31 (pp 22-23)
Rocío Cantero MD, Velázquez IF, Streets AJ, Ong ACM & Cantiello HF (2016) . Biophysical Journal, Vol. 110(3) (pp 611a-612a)
Streets AJ, Xu Y & Ong ACM (2015) . NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 30
Streets AJ, Ibraghimov-Beskrovnaya O & Ong ACM (2003) Regulation of polycystin-1 mediated intercellular adhesion by phosphorylation in renal epithelia cells. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol. 14 (pp 575A-575A)

Preprints

Tran U, Streets AJ, Smith D, Decker E, Kirschfink A, Izem L, Hassey JM, Rutland B, Valluru MK, Bräsen JH , Ott E et al (2024) , Cold Spring Harbor Laboratory.

Research group

PhD Students

Fatima Abdeli-Ali
Debo Adekewola
Tajdida Mayer
Paolo Prosseda
Siavash Rostami Ravi
Devon Smith
Laura Vergoz

Teaching activities

I teach on the following courses:

Molecular Biology and Biochemistry undergraduate module MBB334
MSc Molecular Medicine modules MED6002, 6003 and 6005