Professor Alison Gartland
BSc (Hons), PhD
Clinical Medicine, School of Medicine and Population Health
Professor of Bone and Cancer Biology
+44 114 215 9046
Full contact details
Clinical Medicine, School of Medicine and Population Health
DU34
The Medical School
Beech Hill Road
91直播
S10 2RX
- Profile
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For enquiries, please contact 鈥 ClinMed-Operational@sheffield.ac.uk
I studied Biomedical Technology at 91直播 Hallam University and - following a period in industry - studied for my PhD at The University of Liverpool in Prof Jim Gallagher麓s lab on the "Expression and functional significance of the P2X7 receptor in skeletal tissue".
I then moved to Montpellier, France where I was a Post-Doctoral Researcher at IGMM, CNRS in Bob Hipskind麓s lab. Following this, I was a Senior Post-Doctoral Researcher in the Department of Cell Biology at the University of Massachusetts Medical School USA, in the late Prof Sandy Marks Jnr麓s lab.
I joined the University of 91直播 in 2006 as a Lecturer in Bone Biology.
- Research interests
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My research interests are in P2 receptor signalling in musculoskeletal disease and cancer. The role of P2 purinoreceptor ligands (ATP and other nucleotides) as extracellular messengers is well established and there is now conclusive evidence, from my previous work and that of others, that extracellular nucleotides have a highly influential role in the bone microenvironment. In addition to their roles in bone, nucleotides and P2 receptor signalling have been shown to play a role in cancer.
- Publications
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Featured publications
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All publications
Journal articles
- . iScience, 109288-109288.
- . Journal of Orthopaedic Research.
- . Journal of Bone Oncology, 39, 100474-100474.
- . Frontiers in Endocrinology, 14.
- . Oncogene, 42(4), 259-277.
- . International Journal of Molecular Sciences, 23(16).
- . Frontiers in Endocrinology, 13.
- . Bone Reports, 16, 101209-101209.
- . Frontiers in Bioscience-Landmark, 27(4).
- . Cell Discovery, 8(1).
- . Journal of Bone Oncology, 31.
- . International Journal of Molecular Sciences, 22(10).
- Oral Communications & Poster Abstracts. JBMR PLUS, 5.
- . Cells, 9(11).
- . Cells, 9(11).
- . Scientific Reports, 10(1).
- .
- . Cancer Research, 79(19), 5123-5123.
- . Cancer Research, 78(13_Supplement), 1085-1085.
- . Scientific Reports, 8(1).
- . Journal of Orthopaedic Research, 35(10), 2323-2328.
- . Purinergic Signalling.
- . Cryobiology, 73(3), 416-416.
- . Frontiers in Endocrinology, 7.
- . Journal of Orthopaedic Research.
- . Journal of Bone Oncology.
- . Frontiers in Endocrinology.
- . Purinergic Signalling, 12(1), 103-113.
- . Cancer Research, 76(2), 188-192.
- . Data in Brief, 5, 621-625.
- . NATURE, 522(7554), 106-110.
- . Journal of Orthopaedic Research.
- . Journal of Molecular Endocrinology, 54(2), R75-R88.
- . Journal of Orthopaedic Research, 33(1), 114-121.
- . PLoS ONE, 9(9).
- . Curr Opin Pharmacol, 16, vii-ix.
- . Curr Opin Pharmacol, 16, 122-126.
- . FASEB J, 28(5), 2249-2259.
- . Stem Cells, 31(12), 2747-2758.
- . Purinergic Signalling, 9(3), 281-284.
- . J Bone Miner Res, 28(6), 1446-1456.
- . Genesis, 51(1), 41-49.
- . Journal of Osteoporosis, 2012.
- . Front Endocrinol (Lausanne), 3, 116.
- . BoneKEy Reports, 1(5).
- . Eur J Hum Genet, 20(5), 559-564.
- Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures. European Journal of Human Genetics.
- . Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 1(2), 221-227.
- . Mol Endocrinol, 26(1), 142-152.
- . Front Biosci (Landmark Ed), 17(1), 16-29.
- . J Biomech, 45(3), 549-554.
- . Methods Mol Biol, 816, 3-18.
- . Methods Mol Biol, 806, 357-375.
- . Methods Mol Biol, 806, 337-355.
- . Endocrinology, 152(10), 3706-3716.
- . Bone, 49(4), 717-723.
- Bone phenotypes of P2 receptor knockout mice. Frontiers in Bioscience(S3), 1038-1046.
- . FRONT BIOSCI-LANDMRK, 16, 2572-2585.
- . Cancer Res, 71(5), 1561-1572.
- . PERSPECT PUBLIC HEAL, 131(1), 48-48.
- . Purinergic Signalling, 6(3), 307-315.
- . Purinergic Signalling, 6(1), 125-144.
- The Effect of Different P2X(7) Receptor Antagonists on the Formation and Function of Human Osteoclast in vitro. PURINERG SIGNAL, 6(1), 139-140.
- The role of the P2X鈫7 receptor in bone cell function..
- . American Journal of Pathology, 175(6), 2668-2675.
- . BONE, 40(1), 149-159.
- . Bone, 37(4), 530-544.
- . Connective Tissue Research, 45(1), 1-10.
- . Critical Reviews in Eukaryotic Gene Expression, 13(2-4), 8-8.
- Multinucleated osteoclast formation in vivo and in vitro by P2X(7) receptor-deficient mice. CRIT REV EUKAR GENE, 13(2-4), 243-253.
- P2 receptors in bone - Modulation of osteoclast formation and activity via P2X(7) activation. CRIT REV EUKAR GENE, 13(2-4), 237-242.
- . Calcif Tissue Int, 73(4), 361-369.
- Perspective osteoclastogenesis and growth plate chondrocyte differentiation: Emergence of convergence. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 13(2-4), 181-193.
- Expression of vascular endothelial growth factor in the dental follicle.. Crit Rev Eukaryot Gene Expr, 13(2-4), 173-180.
- . Bone, 31(5), 582-590.
- . J Bone Miner Res, 16(5), 846-856.
- . Bone, 28(5), 507-512.
- . Purinergic Signalling.
- . Cancer Communications.
- . Journal of Clinical Investigation.
- . IBMS BoneKEy, 10.
Chapters
- , Encyclopedia of Bone Biology (pp. 362-378). Elsevier
- The role of purinergic signaling in the interactions between skeletal cells, Nucleotides and Regulation of Bone Cell Function (pp. 61-74).
- (pp. 29-54).
Conference proceedings papers
- . Cancer Research, Vol. 81(13_Supplement) (pp 2904-2904)
- Primordial signalling in prehistoric cancer. JOURNAL OF ANATOMY, Vol. 238(1) (pp 191-191)
- Mechanical loading induced osteogenic response does not interfere with the colonization of breast cancer in bone.. CANCER RESEARCH, Vol. 81(13)
- Longitudinal Effects of Combined Bone Anabolic Interventions on Ovariectomised Mice. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 34 (pp 258-259)
- P2X7R in primary bone cancer. PURINERGIC SIGNALLING, Vol. 14 (pp S13-S14)
- The P2X7 Antagonist AFC-5261 rescues Ovariectomy-induced Bone Loss in Mice.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 29 (pp S402-S403)
- A Novel Factor Derived From Resorbing Bone In Vitro Potently Stimulates C-Fos Expression In Breast Cancer Cells. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28
- P2X7 Receptor Polymorphisms Modulate Osteoblast Cell Functions. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28
- TIBIAL PLATEAU BONE SURFACE ROUGHNESS - A POTENTIAL NEW EARLY MARKER TO DETECT ARTHRITIS?. OSTEOPOROSIS INTERNATIONAL, Vol. 23 (pp S574-S574)
- SPECIATION AND DISTRIBUTION OF COBALT AND CHROMIUM IN OSTEOBLASTS AND OSTEOCLASTS USING MICROFOCUS X-RAY FLUORESCENCE AND X-RAY ABSORPTION NEAR-EDGE STRUCTURE. OSTEOPOROSIS INTERNATIONAL, Vol. 23 (pp S592-S592)
- . BONE, Vol. 50 (pp S85-S86)
- . BONE, Vol. 50 (pp S67-S67)
- . BONE, Vol. 50 (pp S108-S108)
- . BONE, Vol. 48 (pp S126-S126)
- . BONE, Vol. 48 (pp S227-S227)
- . BONE, Vol. 48(1) (pp S21-S21)
- Bone status of P2X7 knockout mice in two different strains. PURINERG SIGNAL, Vol. 6 (pp 158-158)
- The Effect of ATP on cancer cell proliferation in vitro -involvement of multiple P2X Receptors. PURINERG SIGNAL, Vol. 6(1) (pp 140-140)
- Bone Phenotype of P2Y13 Receptor Knock-Out Mice. PURINERG SIGNAL, Vol. 6(1) (pp 144-144)
- The role of P2X(7) receptors in ATP release from osteoblasts. PURINERG SIGNAL, Vol. 6(1) (pp 129-129)
- . BONE, Vol. 46 (pp S71-S71)
- . BONE, Vol. 44 (pp S154-S154)
- Loss of Function Polymorphisms in The P2X(7) Receptor Gene Are Associated with Accelerated Lumbar Spine Bone Loss in Postmenopausal Women.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S296-S296)
- A Novel Selective P2X(7) Receptor Antagonist Inhibits Human Osteoclast Formation in vitro.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S403-S403)
- Microct analysis of P2Y1 and P2Y2 receptor knockout mice demonstrates significant changes in bone phenotype. CALCIFIED TISSUE INT, Vol. 83(1) (pp 2-3)
- ATP release from osteoblasts is increased in response to mechanical loading by different amounts when grown in standard monolayer and novel 3D scaffolds. CALCIFIED TISSUE INT, Vol. 83(1) (pp 16-16)
- The effect of ATP, alone and in combination with EGF, on breast cancer cell survival. PURINERG SIGNAL, Vol. 4 (pp S205-S206)
- A polymorphism in the P2X7 receptor gene is associated with loss of lumbar spine bone mineral density in postmenopausal women. PURINERG SIGNAL, Vol. 4 (pp S172-S173)
- MicroCT analysis of P2Y1 and P2Y2 receptor knockout mice demonstrates significant changes in bone phenotype. PURINERG SIGNAL, Vol. 4 (pp S176-S176)
- Regulation and mechanisms of ATP release from osteoblasts. PURINERG SIGNAL, Vol. 4 (pp S161-S161)
- Different types of mechanical loading induce differentitial ATP release from osteoblasts grown on 3-dimensional scaffolds. PURINERG SIGNAL, Vol. 4 (pp S164-S165)
- Cyclical compressive loading induces changes in cellular behaviour and ATP release from osteoblasts grown on 3-dimensional scaffolds. CALCIFIED TISSUE INT, Vol. 82 (pp S115-S116)
- Novel association between a polymorphism in the P2X7 receptor gene and loss of lumbar spine bone mineral density in postmenopausal women. CALCIFIED TISSUE INT, Vol. 82 (pp S43-S43)
- ATP is released from human osteoblasts by multiple mechanisms.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22 (pp S146-S146)
- . BONE, Vol. 38(3) (pp S11-S11)
- . BONE, Vol. 38(3) (pp S35-S35)
- . BONE, Vol. 38(3) (pp S10-S11)
- Regulation of ATP release from human osteoblasts: A calcium dependant, exocytotic vesicular mechanism. CALCIFIED TISSUE INTERNATIONAL, Vol. 78 (pp S49-S49)
- Differential effect of PPAR agonists on human recombinant RANKL generated osteoclast culture in vitro. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(7) (pp 1303-1303)
- A biphasic pattern of osteoblast gene expression by differing concentrations of PTH 1-34. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(7) (pp 1308-1308)
- ATP release and P2 receptor expression by human chondrocytes.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(7) (pp 1301-1301)
- Effect of PPAR agonists, on human osteoclast formation and activity in vitro. BONE, Vol. 36 (pp S300-S301)
- Cellular and molecular characterization of primary rat chondrocytes differentiated in culture. BONE, Vol. 36 (pp S173-S173)
- The effects of extracellular nucleotides on EGF-induced c-fos gene expression. BONE, Vol. 36 (pp S256-S256)
- Differential effect of PPAR agonists on generation of human osteoclasts in vitro. CLINICA CHIMICA ACTA, Vol. 355 (pp S32-S32)
- Differential effect of PPAR agonists on generation of human osteoclasts in vitro. CLINICA CHIMICA ACTA, Vol. 355 (pp S255-S255)
- Abnormal septoclasts at the chondroosseous junction in the TL rat are normalised following CSF-1 treatment. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(6) (pp 1049-1049)
- Osteopetrotic chondrodysplasia in the toothless (CSF-1null) rat: A paradigm for the role of osteoclastogenic factors as integrators of endochondral ossification. BONE, Vol. 34 (pp S38-S38)
- CSF-1 treatment corrects septoclast abnormalities at the chondroosseous junction in the Toothless rat.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18 (pp S111-S111)
- Chondrocytes from the osteopetrotic mutation toothless (TL)/Csf-1 null rat differentiate in vitro. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18(7) (pp 1370-1370)
- Chondrocytes, growth plates, and RANKL-induced signalling: Observations and implications of osteopetrotic mutations. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 17(7) (pp 1339-1339)
- P2X(7) receptor-deficient mice maintain the ability to form multinucleated) osteoclasts in vivo and in vitro. J BONE MINER RES, Vol. 17(7) (pp 1338-1338)
- Blockade of P2X(7) receptors inhibits osteoclast fusion in vitro. BONE, Vol. 28(5) (pp S166-S167)
- ATP released into the extracellular environment by osteoblasts regulates differentiation and apoptosis of bone cells.. J BONE MINER RES, Vol. 15 (pp S476-S476)
- Expression of the pore forming P2X(7) receptor by human rank ligand-generated osteoclasts and human osteoclastic cells in situ.. J BONE MINER RES, Vol. 15(6) (pp 1227-1227)
- The Effect of ATP on cancer cell proliferation in vitro -involvement of multiple P2X Receptors. Purinergic Signalling, Vol. 6(1) (pp 140). 91直播
Preprints
- Research group
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Current Collaborators
- Professor Mark Wilkinson
- Dr Dawn Teare
- Dr Gaynor Miller
- Dr Shelly Lawson
Postgraduate Students
- Mr Luke Tattersall
- Teaching interests
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I am Chair of the Medical School Graduate Research Committee, I lecture on the undergraduate Medical Course as well as being the academic lead for the research Attachment SSC, I also run the Doctoral Development Programme module "Effective Presentation and Seminar Participation" MED605.
- Professional activities and memberships
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I am the Founder and President of the UK Purine Club, and member of the Bone Research Society, European Calcified Tissue Society, the International Bone and Mineral Society and the American Society for Bone and Mineral Research.