Diana Papaioannou

BChD, MSc

School of Medicine and Population Health

Senior Research Fellow/Portfolio Lead

CTRU Deputy Director

Diana Papaioannou
Profile picture of Diana Papaioannou
d.papaioannou@sheffield.ac.uk
+44 114 222 0766

Full contact details

Diana Papaioannou
School of Medicine and Population Health
3rd floor
The Innovation Centre
217 Portobello
91Ö±²¥
S1 4DP
Profile

Diana Papaioannou is an Assistant Director of the Clinical Trials Research Unit (CTRU) and a Senior Research Fellow with expertise in trial conduct and methodology and CTIMP trials (Clinical Trials of Investigational Medicinal Products).

Diana has extensive experience in designing and implementing large multi-centre trials, particularly CTIMP trials. Since 2014, she has been co-applicant on 8 NIHR funded trials. Diana also held a Clinical Trials Unit (CTU) Efficient Trials award to develop recommendations for recording harms in behaviour change interventions. Diana was the Quality Assurance Lead for 91Ö±²¥ CTRU between 2014 to 2024.

Diana is CTRU lead, providing senior CTRU oversight, for the following studies: EXPERTS-ALS (NIHR158515), MISSION-EB (NHSE/NIHR EME: 127963), PRAISE (NIHR153170) and MAP (NIHR167171).

Diana previously provided CTRU senior oversight and a co-applicant on the MAGIC trial (NIHR HTA: 16/80/08) and STAR-MS trials (NIHR EME: 16/126/26). I provided CTIMP expertise to the ASTIClite trial (NIHR EME: 15/178/09).

In 2019, Diana became Assistant Director at CTRU, responsible for the CTRU management with the CTRU Director and the CTRU management group and coordinating the CTRU
Diana joined the CTRU in May 2011 as the Trial Co-ordinator for a multi-centre randomised controlled trial, REPOSE (The Relative Effectiveness of Pumps over MDI and Structured Education for Type-1 diabetes).

Prior to joining CTRU, she worked with the ScHARR Technology Assessment Group from July 2006, as an Information Specialist and Systematic Reviewer undertaking health technology assessments for the National Institute for Health and Clinical Excellence (NICE) and the NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC).
 

Research interests
  • Clinical trial design
  • Clinical trials of Investigational Medicinal Products
  • Adverse event recording in behavioural trials
  • Systematic reviews
Publications

Show: Featured publications All publications

Books

  • Booth A, Papaioannou D & Sutton A (2012) Systematic Approaches to a Successful Literature Review. Sage Publications Limited. RIS download Bibtex download

Journal articles

  • Hyslop MC, Papaioannou DE, Bolt R, Wilson MJ, Bradburn M, Clarkson J, Herbert E, Ireland N, Kettle J, Loban A , Norrington AC et al (2025) . BJA Open, 13, 100375-100375. RIS download Bibtex download
  • Kettle J, Bolt R, Deery C, Papaioannou D, Rodd H, Hyslop MC, Totton N & Marshman Z (2024) . Trials, 25(1). RIS download Bibtex download
  • Papaioannou D, Hamer-Kiwacz S, Mooney C, Sprange K, Cooper C & O’Cathain A (2024) . BMJ, 387. RIS download Bibtex download
  • Papaioannou D, Sprange K, Hamer-Kiwacz S, Mooney C, Moody G & Cooper C (2024) . Trials, 25. RIS download Bibtex download
  • Papaioannou D, Brazier J & Paisley S (2013) . Value in Health, 16(4), 686-695. RIS download Bibtex download
  • Papaioannou D, Brazier J & Parry G (2013) . J Pers Disord, 27(3), 383-401. RIS download Bibtex download
  • Papaioannou D, Rafia R, Rathbone J, Stevenson M, Buckley Woods H & Stevens J (2012) . Health Technol Assess, 16(37), 1-iv. RIS download Bibtex download
  • Kaltenthaler E, Papaioannou D, Boland A & Dickson R (2011) . Value Health, 14(8), 1158-1165. RIS download Bibtex download
  • Papaioannou D, Brazier J & Parry G (2011) . Value Health, 14(6), 907-920. RIS download Bibtex download
  • Papaioannou D, Rafia R, Stevenson MD, Stevens JW & Evans P (2011) . Health Technol Assess, 15 Suppl 1, 69-75. RIS download Bibtex download
  • Carroll C, Papaioannou D, Rees A & Kaltenthaler E (2011) . Health Technol Assess, 15(16), iii-62. RIS download Bibtex download
  • Papaioannou D, Cooper KL, Carroll C, Hind D, Squires H, Tappenden P & Logan RF (2011) . Colorectal Dis, 13(10), 1085-1099. RIS download Bibtex download
  • Papaioannou D, Sutton A, Carroll C, Booth A & Wong R (2010) . HEALTH INFO LIBR J, 27(2), 114-122. RIS download Bibtex download
  • Cooper K, Squires H, Carroll C, Papaioannou D, Booth A, Logan RF, Maguire C, Hind D & Tappenden P (2010) . Health Technol Assess, 14(32), 1-206. RIS download Bibtex download
  • Wilkinson A, Papaioannou D, Keen C & Booth A (2009) . Health Info Libr J, 26(2), 118-125. RIS download Bibtex download

Chapters

  • Brazier J, Papaioannou D, Cantrell A, Paisley S & Herrmann K (2010) Identifying and reviewing health state utility values for populating decision models In Shemilt I, Mugford M, Vale L, Donaldson C & Marsh K (Ed.), Evidence-Based Decisions and Economics: Health Care, Social Welfare, Education and Criminal Justice (pp. 93-105). Wiley-Blackwell RIS download Bibtex download

Conference proceedings papers

  • Papaioannou D, Peasgood T, Brazier J & Parry G (2011) . VALUE IN HEALTH, Vol. 14(7) (pp A239-A239) RIS download Bibtex download

All publications

Books

  • Booth A, Sutton A & Papaioannou D (2016) Systematic Approaches to a Successful Literature Review. London: SAGE Publications. RIS download Bibtex download
  • Booth A, Papaioannou D & Sutton A (2012) Systematic Approaches to a Successful Literature Review. Sage Publications Limited. RIS download Bibtex download

Journal articles

  • Hyslop MC, Papaioannou DE, Bolt R, Wilson MJ, Bradburn M, Clarkson J, Herbert E, Ireland N, Kettle J, Loban A , Norrington AC et al (2025) . BJA Open, 13, 100375-100375. RIS download Bibtex download
  • Kettle J, Bolt R, Deery C, Papaioannou D, Rodd H, Hyslop MC, Totton N & Marshman Z (2024) . Trials, 25(1). RIS download Bibtex download
  • Papaioannou D, Hamer-Kiwacz S, Mooney C, Sprange K, Cooper C & O’Cathain A (2024) . BMJ, 387. RIS download Bibtex download
  • Brittain G, Cooper C, Glover R, Loban A, Muraro P, Papaioannou D, Roldan E, Sharrack B & Snowden J (2024) . Neurology, 102(17_supplement_1). RIS download Bibtex download
  • Papaioannou D, Sprange K, Hamer-Kiwacz S, Mooney C, Moody G & Cooper C (2024) . Trials, 25. RIS download Bibtex download
  • Herbert E, Papaioannou D, Loban A, Totton N, Hyslop M, Bolt R & Deery C (2024) . Trials, 25(1). RIS download Bibtex download
  • Lindsay JO, Hind D, Swaby E, Berntsson H, Bradburn M, Bannur U, Byrne J, Clarke C, Desoysa L, Dickins B , Din S et al (2024) . The Lancet Gastroenterology and Hepatology. RIS download Bibtex download
  • Papaioannou D, Hamer-Kiwacz S, Mooney C, Cooper C, O’Cathain A, Sprange K & Moody G (2024) . Journal of Clinical Epidemiology, 111275-111275. RIS download Bibtex download
  • Brittain G, Petrie J, Duffy KEM, Glover R, Hullock K, Papaioannou D, Roldan E, Beecher C, Bursnall M, Ciccarelli O , Coles AJ et al (2024) . BMJ Open, 14(2). RIS download Bibtex download
  • Brittain G, Roldan E, Glover R, Cooper C, Papaioannou D, Muraro P, Sharrack B & Snowden AJ (2023) . Journal of the Neurological Sciences, 455, 121832-121832. RIS download Bibtex download
  • Bolt R, Hyslop MC, Herbert E, Papaioannou DE, Totton N, Wilson MJ, Clarkson J, Evans C, Ireland N, Kettle J , Marshman Z et al (2023) . British Journal of Anaesthesia. RIS download Bibtex download
  • Bageta ML, Balboa PL, Glover R, Cooper C, Papaioannou DE, Julious S, Dimairo M, Biggs K, Petrof G & Martinez AE (2023) . British Journal of Dermatology, 189(3), e42-e43. RIS download Bibtex download
  • Mellor K, Papaioannou D, Thomason A, Bolt R, Evans C, Wilson M & Deery C (2022) . BMC Pediatrics, 22(1). RIS download Bibtex download
  • Kettle J, Deery C, Bolt R, Papaioannou D & Marshman Z (2021) . Trials, 22(1). RIS download Bibtex download
  • Papaioannou D, Cooper C, Mooney C, Glover R & Coates E (2021) . Journal of Clinical Epidemiology. RIS download Bibtex download
  • Biggs K, Hind D, Gossage-Worrall R, Sprange K, White D, Wright J, Chatters R, Berry K, Papaioannou D, Bradburn M , Walters SJ et al (2020) . Trials, 21. RIS download Bibtex download
  • Snowden JA, Hawkey C, Hind D, Swaby L, Mellor K, Emsley R, Mandefield L, Lee E, Badoglio M, Polge E , Labopin M et al (2019) . BMC Gastroenterology, 19(1). RIS download Bibtex download
  • Pollard DJ, Brennan A, Dixon S, Waugh N, Elliott J, Heller S, Lee E, Campbell M, Basarir H & White D (2018) . BMJ Open, 8(4), ---. RIS download Bibtex download
  • Jarvis D, Mooney C, Cohen J, Papaioannou D, Bradburn M, Sutton A & Griffiths PD (2017) . European Radiology, 27(6), 2367-2380. RIS download Bibtex download
  • Heller S, White D, Lee E, Lawton J, Pollard D, Waugh N, Amiel S, Barnard K, Beckwith A, Brennan A , Campbell M et al (2017) . Health Technology Assessment, 21(20), 1-278. RIS download Bibtex download
  • Heller S, Amiel S, Campbell M, Choudhary P, Cooper C, Dimairo M, Elliott J, Hammond P, Lee E, Lindsay R , Waugh N et al (2017) . BMJ, 356. RIS download Bibtex download
  • Lawton J, Kirkham J, Rankin D, White DA, Elliott J, Jaap A, Smithson WH, Heller S, Gianfrancesco C, Gordon V , Greaves L et al (2016) . Diabetic Medicine, 33(2), 243-251. RIS download Bibtex download
  • Lawton J, Kirkham J, Rankin D, Barnard K, Cooper CL, Taylor C, Heller S & Elliott J (2014) . Diabetes Research and Clinical Practice, 106(3), 443-450. RIS download Bibtex download
  • Brazier J, Connell J, Papaioannou D, Mukuria C, Mulhern B, Peasgood T, Lloyd MJ, Paisley S, O’Cathain A, Barkham M , Knapp M et al (2014) . Health Technology Assessment, 18(34). RIS download Bibtex download
  • Holmes M, Carroll C & Papaioannou D (2013) . PharmacoEconomics - Italian Research Articles, 15(2), 83-90. RIS download Bibtex download
  • Papaioannou D, Brazier J & Paisley S (2013) . Value in Health, 16(4), 686-695. RIS download Bibtex download
  • Rafia R, Simpson E, Stevenson M & Papaioannou D (2013) . Pharmacoeconomics, 31(6), 471-478. RIS download Bibtex download
  • Papaioannou D, Brazier J & Parry G (2013) . J Pers Disord, 27(3), 383-401. RIS download Bibtex download
  • Brazier J, Mulhern B, Alonso J, Connell J, Papaioannou D & Vilagut G (2012) Are generic preference-based measures valid in mental health? A mixed methods enquiry. QUALITY OF LIFE RESEARCH, 21, 1-1. RIS download Bibtex download
  • Papaioannou D, Rafia R, Rathbone J, Stevenson M, Buckley Woods H & Stevens J (2012) . Health Technol Assess, 16(37), 1-iv. RIS download Bibtex download
  • Kaltenthaler EC, Dickson R, Boland A, Carroll C, Fitzgerald P, Papaioannou D & Akehurst R (2012) . BMJ Open, 2, e000562. RIS download Bibtex download
  • Holmes M, Carroll C & Papaioannou D (2012) . Pharmacoeconomics, 30(2), 137-146. RIS download Bibtex download
  • Kaltenthaler E, Papaioannou D, Boland A & Dickson R (2011) . Value Health, 14(8), 1158-1165. RIS download Bibtex download
  • Papaioannou D, Brazier J & Parry G (2011) . Value Health, 14(6), 907-920. RIS download Bibtex download
  • Harnan SE, Cooper KL, Meng Y, Ward SE, Fitzgerald P, Papaioannou D, Ingram C, Lorenz E, Wilkinson ID & Wyld L (2011) . Eur J Surg Oncol, 37(11), 928-936. RIS download Bibtex download
  • Papaioannou D, Rafia R, Stevenson MD, Stevens JW & Evans P (2011) . Health Technol Assess, 15 Suppl 1, 69-75. RIS download Bibtex download
  • Jones R, Everson-Hock ES, Papaioannou D, Guillaume L, Goyder E, Chilcott J, Cooke J, Payne N, Duenas A, Sheppard LM & Swann C (2011) . Child Care Health Dev, 37(5), 613-622. RIS download Bibtex download
  • Cooper KL, Harnan S, Meng Y, Ward SE, Fitzgerald P, Papaioannou D, Wyld L, Ingram C, Wilkinson ID & Lorenz E (2011) . Eur J Surg Oncol, 37(3), 187-198. RIS download Bibtex download
  • Kaltenthaler E, Boland A, Carroll C, Dickson R, Fitzgerald P & Papaioannou D (2011) . Health Technol Assess, 15(22), 1-iv. RIS download Bibtex download
  • Carroll C, Papaioannou D, Rees A & Kaltenthaler E (2011) . Health Technol Assess, 15(16), iii-62. RIS download Bibtex download
  • Cooper KL, Meng Y, Harnan S, Ward SE, Fitzgerald P, Papaioannou D, Wyld L, Ingram C, Wilkinson ID & Lorenz E (2011) . Health Technol Assess, 15(4), iii-134. RIS download Bibtex download
  • Papaioannou D, Cooper KL, Carroll C, Hind D, Squires H, Tappenden P & Logan RF (2011) . Colorectal Dis, 13(10), 1085-1099. RIS download Bibtex download
  • Papaioannou D, Sutton A, Carroll C, Booth A & Wong R (2010) . HEALTH INFO LIBR J, 27(2), 114-122. RIS download Bibtex download
  • Cooper K, Squires H, Carroll C, Papaioannou D, Booth A, Logan RF, Maguire C, Hind D & Tappenden P (2010) . Health Technol Assess, 14(32), 1-206. RIS download Bibtex download
  • Simpson EL, Rafia R, Stevenson MD & Papaioannou D (2010) . Health Technol Assess, 14 Suppl 1, 63-67. RIS download Bibtex download
  • Carroll C, Cooper K, Papaioannou D, Hind D, Pilgrim H & Tappenden P (2010) . CLIN THER, 32(5), 789-803. RIS download Bibtex download
  • Chilcott J, Tappenden P, Rawdin A, Johnson M, Kaltenthaler E, Paisley S, Papaioannou D & Shippam A (2010) . Health Technol Assess, 14(25), iii-107. RIS download Bibtex download
  • Carroll C, Cooper K, Papaioannou D, Hind D, Tappenden P, Pilgrim H & Booth A (2010) . Aliment Pharmacol Ther, 31(7), 708-718. RIS download Bibtex download
  • Stevenson MD, Simpson EL, Rawdin AC & Papaioannou DE (2010) A review of discrete event simulation in National Coordinating Centre for Health Technology Assessment-funded work and a case study exploring the cost-effectiveness of testing for thrombophilia in patients presenting with an initial idiopathic venous thromboembolism.. J. Simulation, 4, 14-23. RIS download Bibtex download
  • Pandor A, Fitzgerald P, Stevenson M & Papaioannou D (2009) . HEALTH TECHNOL ASSES, 13, 55-60. RIS download Bibtex download
  • Stevenson M, Lloyd-Jones M & Papaioannou D (2009) Vitamin K to prevent fractures in older women: systematic review and economic evaluation.. Health technology assessment (Winchester, England), 13(45). RIS download Bibtex download
  • Holmes M, Carroll C & Papaioannou D (2009) . Health Technol Assess, 13 Suppl 2, 55-62. RIS download Bibtex download
  • Stevenson M, Lloyd-Jones M & Papaioannou D (2009) . Health Technol Assess, 13(45), iii-134. RIS download Bibtex download
  • Wilkinson A, Papaioannou D, Keen C & Booth A (2009) . Health Info Libr J, 26(2), 118-125. RIS download Bibtex download
  • Simpson EL, Duenas A, Holmes MW, Papaioannou D & Chilcott J (2009) . Health Technol Assess, 13(17), iii-154. RIS download Bibtex download
  • Booth A, Carroll C, Papaioannou D, Sutton A & Wong R (2009) . Health Info Libr J, 26(1), 4-21. RIS download Bibtex download
  • Simpson EL, Stevenson MD, Rawdin A & Papaioannou D (2009) . Health Technol Assess, 13(2), iii-91. RIS download Bibtex download
  • Carroll C, Booth A, Papaioannou D, Sutton A & Wong R (2009) . J Contin Educ Health Prof, 29(4), 235-241. RIS download Bibtex download
  • Lindsay JO, Hind D, Swaby L, Berntsson H, Bradburn M, Bannur C U, Byrne J, Clarke C, Desoysa L, Din S , Emsley R et al () . Efficacy and Mechanism Evaluation, 1-106. RIS download Bibtex download
  • Dawett B, Deery C, Banerjee A, Papaioannou D & Marshman Z () . British Dental Journal. RIS download Bibtex download

Chapters

  • Brazier J, Papaioannou D, Cantrell A, Paisley S & Herrmann K (2010) Identifying and reviewing health state utility values for populating decision models In Shemilt I, Mugford M, Vale L, Donaldson C & Marsh K (Ed.), Evidence-Based Decisions and Economics: Health Care, Social Welfare, Education and Criminal Justice (pp. 93-105). Wiley-Blackwell RIS download Bibtex download

Conference proceedings papers

  • Brittain G, Glover R, Roldan E, Papaioannou D, Cooper C, Muraro P, Snowden J & Sharrack B (2022) A changing target - adapting ongoing autologous haematopoietic stem cell transplantation clinical trials to evolving clinical practice in the treatment of highly active relapsing remitting multiple sclerosis. MULTIPLE SCLEROSIS JOURNAL, Vol. 28(3_SUPPL) (pp 843-843) RIS download Bibtex download
  • Papaioannou D, Peasgood T, Brazier J & Parry G (2011) . VALUE IN HEALTH, Vol. 14(7) (pp A239-A239) RIS download Bibtex download
  • Rafia R, Papaioannou D, Stevenson M, Rathbone J & Woods HB (2011) . VALUE IN HEALTH, Vol. 14(7) (pp A445-A445) RIS download Bibtex download

Reports

  • Ara R, Keetharuth D, Papaioannou D, Cantrell A & Brazier JE (2011) Evaluating public health interventions for obesity from the perspective of local health authorities. RIS download Bibtex download

Posters

  • Biggs K, Hind D, Gossage-Worrall R, Sprange K, White D, Wright J, Chatters R, Berry K, Papaioannou D, Bradburn M , Walters SJ et al (2019) Challenges in the design, planning and implementation of trials evaluating group interventions. RIS download Bibtex download
  • Rafia R, Papaioannou D, Stevenson M, Rathbone J & Woods H Evaluating the cost-effectiveness of the addition of rituximab to chemotherapy in the first-line treatment of Follicular Lymphoma patients in the UK. RIS download Bibtex download
  • Harnan S, Cooper K, Meng Y, Ward S, Fitzgerald P, Papaioannou D, Wyld L, Ingram C, Wilkinson I & Lorenz E Magnetic resonance imaging (MRI) for assessment of axillary lymph node metastases in breast cancer: systematic review. RIS download Bibtex download
  • Carroll C, Papaioannou D & Harnan S Surgical interventions for the primary prophylaxis of retinal detachment in Stickler Syndrome: a systematic review. RIS download Bibtex download
Research group

CTRU, DTS

Grants

Metformin and Psychosis Weight Prevention Trial (MAP Trial). NIHR HTA.
Coapplicant. £3million

EXPErimental medicine Route To Success in Amyotrophic Lateral Sclerosis
(EXPERTS-ALS) NIHR EME and NIHR BRC. Coapplicant. £4,796,266.62. Start date:
1 Sep 2023.

Recording Harms in Behavioural change Intervention Trials (RHABIT) Project. NIHR CTU support funding for Efficient trials. Principal Investigator. £79,015

MissionEB trial: Double blinded placebo control study of Mesenchymal Intravenous
Stromal cell Infusions in children with recessive dystrophic Epidermolysis Bullosa.
Coapplicant. £2,539,714. Start date Aug 2020

STAR-MS trial: Autologous Stem Cell Transplantation versus Alemtuzumab in
Relapsing Remitting MS. Coapplicant. £2,350,322. Start date Jan 2019

The MAGIC trial: Melatonin for Anxiety prior to General Anaesthesia. HTA 16/80/08,
Coapplicant.£1.65million. Dec 2017 to September 2024.

Autologous Stem Cell Transplantation In refractory Crohns disease - Low Intensity
Therapy Evaluation (ASTIC-LITE). Sep 2017 to 2021

SCRATCH trial (Induced Endometrial Trauma in IVF). HTA 14/08/05, Coapplicant.
£1.25million. Dec 2015 to Sep 2020

Teaching interests

I am interested in supervising research students in areas such as RCT methodology and evaluation of health technologies.