Bacila, Irina-Alexandra, Dr

Dr Irina-Alexandra Bacila

PhD, PGDip, MRCPCH

School of Medicine and Population Health

NIHR Academic Clinical Lecturer in Paediatrics

i.bacila@sheffield.ac.uk
+44 114 215 9022

EU10, E Floor, The Medical School

Full contact details

Dr Irina-Alexandra Bacila
School of Medicine and Population Health
EU10, E Floor
The Medical School
Beech Hill Road
91ֱ��
S10 2RX

Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

I joined the University of 91ֱ�� in 2018 when I started a four-year post as Clinical Research Fellow in Paediatrics. This marked the beginning of my research activity within the Department of Oncology and Metabolism at 91ֱ�� and the Endocrine Team at 91ֱ�� Children’s Hospital. During this time, I also completed a PhD in Endocrinology studying metabolic complications in congenital adrenal hyperplasia (CAH). I am dedicated to developing a career as a Clinical Academic, and I am currently working as a Clinical Lecturer in Paediatrics, dividing my time between academic work in the School of Medicine and Population Health, and clinical training in Paediatric Endocrinology at The 91ֱ�� Children’s Hospital.

Qualifications

PhD in Endocrinology, 91ֱ��, 91ֱ�� (2023)
Postgraduate Diploma in Child Health, Leeds University, Leeds (2018)
Membership of the Royal College of Paediatrics and Child Health (MRCPCH) (2015)
Specialty Exam in Paediatrics, Cluj, Romania, Qualification: Specialty Doctor in Paediatrics (2012)
University of Medicine and Pharmacy, Cluj, Romania (2007)

Research interests: My research interests are adrenal disease, disorders of steroid synthesis and disorders of sexual development. I have explored these areas in clinical research involving patients with congenital adrenal hyperplasia (CAH) and also in Basic Science research, using zebrafish models of abnormal steroid synthesis. I am also interested in using bioinformatics in combination with metabolomics and transcriptomics to explore molecular mechanisms involved in the pathophysiology of endocrine and metabolic disease.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Eachus H, Oberski L, Paveley J, Bacila I, Ashton J-P, Esposito U, Seifuddin F, Pirooznia M, Elhaik E, Placzek M , Krone N et al (2023) . Disease Models & Mechanisms, 16(9).
Bacila I, Lawrence NR, Badrinath SG, Balagamage C & Krone NP (2023) . Clinical Endocrinology.
Lawrence NR, Bacila I, Dawson J, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH , Gevers E et al (2023) . The Journal of Clinical Endocrinology & Metabolism, 109(1), e336-e346.
Bacila I, Lawrence NR, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E , Krone RE et al (2022) . European Journal of Endocrinology, 187(4), 543-553.
Lawrence N, Bacila I, Dawson J, Bryce J, Ali SR, van den Akker ELT, Bachega TASS, Baronio F, Birkebæk NH, Bonfig W , Claahsen van der Grinten H et al (2022) . Clinical Endocrinology, 97(5), 551-561.
Bacila I, Cunliffe VT & Krone NP (2021) . Molecular and Cellular Endocrinology, 535, 111372-111372.
Bacila I, Freeman N, Daniel E, Sandrk M, Bryce J, Ali SR, Yavas Abalı Z, Atapattu N, Bachega TA, Balsamo A , Birkebæk N et al (2021) . European Journal of Endocrinology, 184(4), 553-563.
Bacila I, Adaway J, Hawley J, Mahdi S, Krone R, Patel L, Alvi S, Randell T, Gevers E, Dattani M , Cheetham T et al (2019) . The Journal of Clinical Endocrinology & Metabolism, 104(12), 6417-6429.
Bacila I-A, Elder C & Krone N (2019) . Archives of Disease in Childhood, 104(12), 1223-1228.
Balagamage C, Lawrence NR, Krone R, Bacila IA & Krone NP () . Hormone Research in Paediatrics, 1-11.

All publications

Journal articles

Eachus H, Oberski L, Paveley J, Bacila I, Ashton J-P, Esposito U, Seifuddin F, Pirooznia M, Elhaik E, Placzek M , Krone N et al (2023) . Disease Models & Mechanisms, 16(9).
Bacila I, Lawrence NR, Badrinath SG, Balagamage C & Krone NP (2023) . Clinical Endocrinology.
Lawrence NR, Bacila I, Dawson J, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH , Gevers E et al (2023) . The Journal of Clinical Endocrinology & Metabolism, 109(1), e336-e346.
Bacila I, Lawrence NR, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E , Krone RE et al (2022) . European Journal of Endocrinology, 187(4), 543-553.
Lawrence N, Bacila I, Dawson J, Bryce J, Ali SR, van den Akker ELT, Bachega TASS, Baronio F, Birkebæk NH, Bonfig W , Claahsen van der Grinten H et al (2022) . Clinical Endocrinology, 97(5), 551-561.
Bacila I, Cunliffe VT & Krone NP (2021) . Molecular and Cellular Endocrinology, 535, 111372-111372.
Bacila I-A, Lawrence N, Mahdi S, Alvi S, Cheetham T, Crowne E, Das U, Dattani M, Davies JH, Gevers EF , Krone R et al (2021) . Journal of the Endocrine Society, 5(Supplement_1), A717-A717.
Bacila I, Freeman N, Daniel E, Sandrk M, Bryce J, Ali SR, Yavas Abalı Z, Atapattu N, Bachega TA, Balsamo A , Birkebæk N et al (2021) . European Journal of Endocrinology, 184(4), 553-563.
Bacila I, Adaway J, Hawley J, Mahdi S, Krone R, Patel L, Alvi S, Randell T, Gevers E, Dattani M , Cheetham T et al (2019) . The Journal of Clinical Endocrinology & Metabolism, 104(12), 6417-6429.
Bacila I-A, Elder C & Krone N (2019) . Archives of Disease in Childhood, 104(12), 1223-1228.
Ferguson GR, Bacila IA & Swamy M (2016) . BMJ Open, 6(4), e010054-e010054.
Lawrence NR, Bacila IA, Collins GS, Dawson J, Lang Z-Q, Ji X, Ahmed SF, Alvi S, Bath LE, Blair J , Cheetham T et al () . Hormone Research in Paediatrics, 1-11.
Balagamage C, Lawrence NR, Krone R, Bacila IA & Krone NP () . Hormone Research in Paediatrics, 1-11.

Conference proceedings papers

Lawrence NR, Bacila I, Tonge J, Dawson J, Collins GS, Lang Z-Q, Bryce J, Alimussina M, Chen M, Ali SR , Adam S et al (2024) Variation in Blood Pressure in Young Adults with 21a-Hydroxylase Deficiency: Longitudinal Multilevel Modelling of Data from the I-CAH Registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 154-155)
Panchigar K, Tonge J, Bacila I, Bryce J, Alimussina M, Koley S, Ahmed SF, Lawrence NR & Krone N (2024) An exploration of a data visualisation web application for rare disease registries. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 514-514)
Tonge JJ, Bacila I, Lawrence NR, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E , Keevil B et al (2024) Non-invasive biochemical monitoring for Congenital Adrenal Hyperplasia: use of urinary steroid metabolites and salivary 17α-Hydroxyprogesterone. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 209-210)
Lawrence NR, Bacila I, Tonge J, Dawson J, Collins GS, Lang Z-Q, Bryce J, Alimussina M, Chen M, Ali SR , Adam S et al (2024) Impact of Fludrocortisone on Blood Pressure in Young Children Under 5 with CAH in the I-CAH Registry: Autoregressive Causal Inference Analysis. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 153-154)
Oberski L, Bacila I, Cunliffe V & Krone N (2023) The pathophysiologic response of central nervous system due to differently impaired steroidogenesis. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 27-28)
Bacila I, Lawrence NR, Ji X, Ahmed SF, Alvi S, Bath L, Blair J, Cheetham T, Crowne L, Davies JH , Dattani M et al (2023) National service evaluation project analysing the quality of care for children and young people with congenital adrenal hyperplasia in the United Kingdom: Data from patients and clinicians. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 418-419)
Bacila I, Oberski L, Cunliffe V & Krone N (2023) Metabolic effects of cortisol insufficiency are sex-depended in a zebrafish model of 21-hydroxylase deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 135-135)
Baker EL, Ellis J, Jayes S, Kingsley R, Lee A, Mitchell D, Peakman E, Smith DP, Watts W & Bacila IA (2023) York Paediatric Diabetes Team: A rewarding quality improvement project in children with type 1 diabetes. DIABETIC MEDICINE, Vol. 40
Bacila I, Li N, Eachus H, Storbeck K-H, Cunliffe VT & Krone NP (2022) Towards understanding the metabolic phenotype of glucocorticoid deficiency in 21-hydroxylase deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 95(SUPPL 2) (pp 79-79)
Lawrence NR, Bacila I, Dawson J, Ali SR, van den Akker ELT, Sartori Sanchez Bachega TA, Baronio F, Birkebaek NH, Bonfig W, van der Grinten C , Cools M et al (2022) Blood pressure (BP) status in Congenital Adrenal Hyperplasia (CAH) - longitudinal analysis of real world data from the I-CAH registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 95(SUPPL 2) (pp 112-113)
Lawrence NR, Bacila I-A, Mahdi S, Albi S, Cheetham TD, Crowne EC, Das U, Dawson J, Dattani MT, Davies J , Gevers E et al (2021) . Journal of the Endocrine Society, Vol. 5(Supplement_1) (pp A720-A720). Virtual meeting, 20 March 2021 - 20 March 2021.
Bacila I, Lawrence N, Alvi S, Cheetham T, Crowne E, Das U, Dattani M, Davies JH, Gevers E, Krone R , Kyriakou A et al (2021) Re-appraising the use of urinary steroid profiles for assessing therapy control in children with 21-hydroxylase deficiency - results from the CAH-UK cohort study. HORMONE RESEARCH IN PAEDIATRICS, Vol. 94(SUPPL 1) (pp 27-27)
Lawrence N, Bacila I, Dawson J, Bryce J, van den Akker EL, Sartori Sanchez Bachega TA, Baronio F, Birkebaek NH, Bonfig W, Claahsen H , Costa EC et al (2021) Variation of glucocorticoid dose and biomarkers in children with congenital adrenal hyperplasia longitudinal analysis of real world data from the I-CAH registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 94(SUPPL 1) (pp 26-26)
Lawrence N, Bacila I, Dawson J, Bryce J, van den Akker E, Sartori Sanchez Bachega TA, Baronio F, Birkebaek NH, Bonfig W, Claahsen H , Costa EC et al (2021) International practice of therapy monitoring in congenital adrenal hyperplasia - Real World data from the I-CAH registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 94(SUPPL 1) (pp 67-68)

Datasets

Bacila I-A .