Harrity, Joseph P.A., Professor

Professor Joseph P.A. Harrity

School of Mathematical and Physical Sciences

Chemistry Recruitment Lead

Professor of Synthetic Organic Chemistry

j.harrity@sheffield.ac.uk
+44 114 222 9496

Dainton Building

Full contact details

Professor Joseph P.A. Harrity
School of Mathematical and Physical Sciences
Dainton Building
13 Brook Hill
91ֱ��
S3 7HF

Profile

Prof. Harrity obtained his BSc (Hons.) in Chemistry from the University of Strathclyde in 1991, followed by a PhD from the same institution in 1994. He was a Postdoctoral Research Fellow at Boston College, USA from 1994 to 1997, after which he became a Lecturer at the University of 91ֱ��. Here he was promoted to Senior Lecturer and Reader. He was promoted to Professor in 2009.

In October 2012, Prof. Harrity was appointed to a 3 year Royal Society Industry Fellowship to undertake a collaboration with Peakdale Molecular. During this time, he worked with Peakdale to develop novel functionalised intermediates on commercially relevant scales, thereby introducing new scaffolds into their catalogue portfolio.

Awards

Pfizer Discovery Award (2004)
AstraZeneca Research Award (2006)
Royal Society Industry Fellowship (2012-2015)
RSC Bader Award (2018)

Research interests

Synthesis provides the opportunity to design and prepare specific molecules whilst exploring novel processes that further develop the field of organic chemistry. In this context, our programme has concentrated on new and selective carbon-carbon bond forming strategies for the preparation of functionalised synthetic Intermediates. A summary of projects currently under investigation is outlined below:

Synthesis of Heteroaromatic Boronic acid Derivatives: Aromatic boronic acids are extremely useful and versatile substrates in modern organic chemistry. We have developed a strategically novel approach to these compounds through cycloaddition reactions of alkynylboronic esters. To date, this approach has allowed us to generate a range of boronic acids based on benzene, pyridine, pyrazole, thiophene, indoles amongst others.

Natural products Synthesis: We have developed a [3 + 3] annelation approach to functionalised nitrogen and oxygen heterocycles. This chemistry has provided a platform for the synthesis of a range of alkaloid and marine natural products.

Publications

Journal articles

Hoteite L, Allen BDW, Elhajj EA, Meijer AJHM & Harrity JPA (2024) . Chemistry – A European Journal.
Valdez Pérez LF, Bachollet SPJT, Orlov NV, Kopf KPM & Harrity JPA (2022) . Angewandte Chemie International Edition.
Han J, Hoteite L & Harrity JPA (2022) . Chemistry – A European Journal.
García-Vázquez V, Hoteite L, Lakeland CP, Watson DW & Harrity JPA (2021) . Organic Letters, 23(7), 2811-2815.
Harrity JPA, Cousins DL, Fricero P, Kopf KPM, McColl EJ, Czechtizky W & Lim YH (2021) . Angewandte Chemie International Edition.
Harrity JPA, Mora-Radó H, Czechtizky W & Méndez M (2020) . ChemMedChem.
Avgoustou P, Jailani ABA, Zirimwabagabo J-O, Tozer MJ, Gibson KR, Glossop PA, Mills JEJ, Porter RA, Blaney P, Bungay P , WANG N et al (2020) . ACS Pharmacology & Translational Science.
Holmes T, Brown AW, Suggitt M, Shaw LA, Simpson L, Harrity JPA, Tozer GM & Kanthou C (2020) . Scientific Reports, 10(1).
Harrity JPA, Fricero P, Bialy L, Czechtizky W & Mendez M (2020) . ChemMedChem.
Al-Saedy MAE & Harrity JPA (2020) . Synlett.
Harrity JPA, Lakeland CP & Watson DW (2019) . Chemistry – A European Journal.
Ball-Jones MP, Tyler J, Mora-Radó H, Czechtizky W, Méndez M & Harrity JPA (2019) . Organic Letters, 21(17), 6821-6824.
Brown AW, Holmes T, Fisher M, Tozer GM, Harrity JPA & Kanthou C (2018) . ChemMedChem, 13(24), 2600-2600.
Harrity JPA, Brown A, Holmes T, Fisher M, Tozer G & Kanthou C (2018) . ChemMedChem.
Maiden TMM, Mbelesi N, Procopiou PA, Swanson S & Harrity JPA (2018) . Organic and Biomolecular Chemistry.
Mora-Radó H, Sotorríos L, Ball-Jones MP, Bialy L, Czechtizky W, Méndez M, Gómez-Bengoa E & Harrity JPA (2018) . Chemistry - A European Journal, 24(38), 9530-9534.
Fricero P, Bialy L, Czechtizky W, Méndez M & Harrity JPA (2018) . Organic Letters, 20(1), 198-200.
Kakaawla TKK & Harrity JPA (2018) . Organic Letters, 20(1), 201-203.
Al-Saedy MAE, Nassoy ACMA & Harrity JPA (2017) . Synlett.
Allen BDW, Lakeland CP & Harrity JPA (2017) . Chemistry - A European Journal, 23(56).
Allen BDW, Lakeland CP & Harrity JPA (2017) . Chemistry - A European Journal, 23(56), 13830-13857.
Brown AW & Harrity JPA (2017) . Tetrahedron, 73(22), 3160-3172.
Harrity JPA, Brown A & Comas-Barcelo J (2017) . Chemistry - A European Journal.
Wezeman T, Comas-Barceló J, Nieger M, Harrity JP & Bräse S (2017) . Organic and Biomolecular Chemistry, 15(7), 1575-1579.
Fricero P, Bialy L, Brown AW, Czechtizky W, Méndez M & Harrity JPA (2017) . The Journal of Organic Chemistry, 82(3), 1688-1696.
Comas-Barceló J & Harrity JPA (2016) . Synthesis.
Maiden TMM, Swanson S, Procopiou PA & Harrity JPA (2016) . The Journal of Organic Chemistry, 81(22), 10641-10650.
Brown AW, Fisher M, Tozer GM, Kanthou C & Harrity JP (2016) . J Med Chem, 59(20), 9473-9488.
Allen BDW, Connolly MJ & Harrity JPA (2016) . Chemistry - A European Journal, 22(37).
Allen B, Connolly M & Harrity JP (2016) . Chemistry, 22(37), 13000-13003.
Bachollet SPJT, Volz D, Fiser B, Münch S, Rönicke F, Carrillo J, Adams H, Schepers U, Gómez-Bengoa E, Bräse S & Harrity JPA (2016) . Chemistry - A European Journal, 22(35), 12430-12438.
Maiden TMM & Harrity JPA (2016) . Org. Biomol. Chem..
Maiden TM, Swanson S, Procopiou PA & Harrity JP (2016) . Organic Letters, 18(14), 3434-3437.
Mora-Radó H, Bialy L, Czechtizky W, Méndez M & Harrity JPA (2016) . Angewandte Chemie, 128(19), 5928-5930.
Mora‐Radó H, Bialy L, Czechtizky W, Méndez M & Harrity JPA (2016) . Angewandte Chemie International Edition, 55(19), 5834-5836.
Comas-Barceló J, Blanco-Ania D, van den Broek SAMW, Nieuwland PJ, Harrity JPA & Rutjes FPJT (2016) . Catal. Sci. Technol., 6(13), 4718-4723.
Edeson SJ, Maduli EJM, Swanson S, Procopiou PA & Harrity JPA (2016) . European Journal of Organic Chemistry, 2016(1), 83-86.
Kakaawla TKK, Hartley WC & Harrity JPA (2016) . European Journal of Organic Chemistry, 2016(16), 2789-2792.
Maiden TMM, Swanson S, Procopiou PA & Harrity JP (2015) . Chemistry a European Journal, 21(41), 14342-14346.
Brown AW & Harrity JPA (2015) . The Journal of Organic Chemistry, 80(4), 2467-2472.
Comas-Barceló J, Foster RS, Fiser B, Gomez-Bengoa E & Harrity JPA (2015) . Chemistry - A European Journal, 21(8), 3257-3263.
Maduli EJM, Edeson SJ, Swanson S, Procopiou PA & Harrity JPA (2015) . Organic Letters, 17(2), 390-392.
Stalling T, Harker WRR, Auvinet A-L, Cornel EJ & Harrity JPA (2015) . Chemistry - A European Journal, 21(6), 2701-2704.
Crépin DFP, Harrity JPA, Jiang J, Meijer AJHM, Nassoy A-CMA & Raubo P (2014) . J Am Chem Soc, 136(24), 8642-8653.
Edeson SJ, Jiang J, Swanson S, Procopiou PA, Adams H, Meijer AJHM & Harrity JPA (2014) . Org Biomol Chem, 12(20), 3201-3210.
Mortimer D, Whiting M, Harrity JPA, Jones S & Coldham I (2014) . Tetrahedron Letters, 55(6), 1255-1257.
Bachollet SPJT, Vivat JF, Cocker DC, Adams H & Harrity JPA (2014) . Chemistry - A European Journal, 20(40), 12889-12893.
Zirimwabagabo J-O & Harrity JPA (2014) . Chem Commun (Camb), 50(21), 2735-2737.
Crépin DF & Harrity JPA (2013) . Org Lett, 15(16), 4222-4225.
Foster RS, Adams H, Jakobi H & Harrity JPA (2013) . J Org Chem, 78(8), 4049-4064.
Nassoy A-C, Harrity JPA & Raubo P (2013) . Tetrahedron Letters.
Fraser CJ, Howell GP & Harrity JPA (2012) . Org Biomol Chem, 10(45), 9058-9066.
Kirkham JD, Edeson SJ, Stokes S & Harrity JPA (2012) . Org Lett, 14(20), 5354-5357.
Foster RS, Jakobi H & Harrity JPA (2012) . Org Lett, 14(18), 4858-4861.
Kirkham JD, Butlin RJ & Harrity JPA (2012) . Angewandte Chemie, 124(26), 6508-6511.
Kirkham JD, Butlin RJ & Harrity JPA (2012) . Angew Chem Int Ed Engl, 51(26), 6402-6405.
Harker WRR, Harrity JPA, Delaney PM, Simms M & Tozer MJ (2012) . Tetrahedron.
Kirkham JD, Leach AG, Row EC & Harrity JPA (2012) Investigation of the Origins of Regiochemical Control in [4+2] Cycloadditions of 2-Pyrones and Alkynylboronates. Synthesis, 44.
Mancey NC, Sandon N, Auvinet A-L, Butlin RJ, Czechtizky W & Harrity JPA (2011) . Chem Commun (Camb), 47(35), 9804-9806.
Auvinet A & Harrity JPA (2011) . Angewandte Chemie, 123(12), 2821-2824.
Auvinet A-L & Harrity JPA (2011) . Angew Chem Int Ed Engl, 50(12), 2769-2772.
Foster RS, Jakobi H & Harrity JPA (2011) Regioselectivity studies of sydnone cycloaddition reactions of azine-substituted alkynes. Tetrahedron Letters.
Foster RS, Jakobi H & Harrity JPA (2011) . Tetrahedron Letters, 52(13), 1506-1508.
Huang J, Macdonald SJF & Harrity JPA (2010) . Chem Commun (Camb), 46(46), 8770-8772.
Brioche JCR, Barker TA, Whatrup DJ, Barker MD & Harrity JPA (2010) . Org Lett, 12(21), 4832-4835.
Kirkham JD, Delaney PM, Ellames GJ, Row EC & Harrity JPA (2010) . Chem Commun (Camb), 46(28), 5154-5156.
Auvinet A-L, Harrity JPA & Hilt G (2010) . J Org Chem, 75(11), 3893-3896.
Browne DL, Taylor JB, Plant A & Harrity JPA (2010) . J Org Chem, 75(3), 984-987.
Crossley JA, Kirkham JD, Browne DL & Harrity JPA (2010) On the use of 2-(trimethylsilyl)iodobenzene as a benzyne precursor. Tetrahedron Letters.
Browne DL & Harrity JPA (2010) . Tetrahedron, 66(3), 553-568.
Vivat JF, Adams H & Harrity JPA (2010) . Org Lett, 12(1), 160-163.
Foster RS, Huang J, Vivat JF, Browne DL & Harrity JPA (2009) . Org Biomol Chem, 7(19), 4052-4056.
Browne DL, Vivat JF, Plant A, Gomez-Bengoa E & Harrity JPA (2009) . J Am Chem Soc, 131(22), 7762-7769.
Huang J, Macdonald SJF & Harrity JPA (2009) . Chem Commun (Camb)(4), 436-438.
Browne DL, Taylor JB, Plant A & Harrity JPA (2009) . J Org Chem, 74(1), 396-400.
Jamookeeah CE, Beadle CD & Harrity JPA (2009) . Synthesis(1), 133-137.
Huang J, Macdonald SJF, Cooper AWJ, Fisher G & Harrity JPA (2009) . Tetrahedron Letters, 50(39), 5539-5541.
Brioche JCR, Goodenough KM, Whatrup DJ & Harrity JPA (2008) . J Org Chem, 73(5), 1946-1953.
Delaney PM, Huang J, Macdonald SJF & Harrity JPA (2008) . Org Lett, 10(5), 781-783.
Jamookeeah CE, Beadle CD, Jackson RFW & Harrity JPA (2008) . J Org Chem, 73(3), 1128-1130.
Pattenden LC, Adams H, Smith SA & Harrity JPA (2008) . Tetrahedron, 64(13), 2951-2961.
Mancey NC, Butlin RJ & Harrity JPA (2008) . Synlett(17), 2647-2650.
Harrity JPA (2008) . Tetrahedron, 64(5), 767.
Delaney PM, Browne DL, Adams H, Plant A & Harrity JPA (2008) . Tetrahedron, 64(5), 866-873.
Browne DL, Helm MD, Plant A & Harrity JPA (2007) . Angewandte Chemie, 119(45), 8810-8812.
Brioche JCR, Goodenough KM, Whatrup DJ & Harrity JPA (2007) . Org Lett, 9(20), 3941-3943.
Meek SJ, Pradaux F, Demont EH & Harrity JPA (2007) . J Org Chem, 72(9), 3467-3477.
Gomez-Bengoa E, Helm MD, Plant A & Harrity JPA (2007) . J Am Chem Soc, 129(9), 2691-2699.
Meek SJ, Demont EH & Harrity JPA (2007) . Tetrahedron Letters, 48(24), 4165-4168.
Helm MD, Plant A & Harrity JPA (2007) . Synlett(18), 2885-2887.
Meek SJ & Harrity JPA (2007) . Tetrahedron, 63(15), 3081-3092.
Browne DL, Helm MD, Plant A & Harrity JPA (2007) . Angew Chem Int Ed Engl, 46(45), 8656-8658.
Provoost OY, Hazelwood AJ & Harrity JPA (2007) . Beilstein J Org Chem, 3, 8.
Helm MD, Plant A & Harrity JPA (2006) . Org Biomol Chem, 4(23), 4278-4280.
Meek SJ, Pradaux F, Demont EH & Harrity JPA (2006) . Org Lett, 8(24), 5597-5600.
Delaney PM, Moore JE & Harrity JPA (2006) . Chem Commun (Camb)(31), 3323-3325.
Pattenden LC, Wybrow RAJ, Smith SA & Harrity JPA (2006) . Org Lett, 8(14), 3089-3091.
Harrity JPA (2006) Highly substituted pyridazines (Angew. Chem. Int. Ed 2005, 44, 3889). LETT ORG CHEM, 3(2), 78-78.
Stevenson NG, De Savi C & Harrity JPA (2006) . Synlett(14), 2272-2274.
Provoost OY, Hedley SJ, Hazelwood AJ & Harrity JPA (2006) . Tetrahedron Letters, 47(3), 331-333.
Meek SJ, Pradaux F, Carbery DR, Demont EH & Harrity JPA (2005) . J Org Chem, 70(24), 10046-10056.
Goodenough KM, Raubo P & Harrity JPA (2005) . Org Lett, 7(14), 2993-2996.
Helm MD, Moore JE, Plant A & Harrity JPA (2005) . Angewandte Chemie, 117(25), 3957-3960.
Helm MD, Moore JE, Plant A & Harrity JPA (2005) . Angew Chem Int Ed Engl, 44(25), 3889-3892.
Harrity JPA & Provoost O (2005) . Org Biomol Chem, 3(8), 1349-1358.
Goodenough KM, Moran WJ, Raubo P & Harrity JPA (2005) . J Org Chem, 70(1), 207-213.
Moore JE, Davies MW, Goodenough KM, Wybrow RAJ, York M, Johnson CN & Harrity JPA (2005) . Tetrahedron, 61(28), 6707-6714.
Moore JE, York M & Harrity JPA (2005) . Synlett(5), 860-862.
Hoveyda AH, Gillingham DG, Van Veldhuizen JJ, Kataoka O, Garber SB, Kingsbury JS & Harrity JPA (2004) . Org Biomol Chem, 2(1), 8-23.
Wybrow RAJ, Edwards AS, Stevenson NG, Adams H, Johnstone C & Harrity JPA (2004) . Tetrahedron, 60(40), 8869-8880.
Wybrow RAJ, Stevenson NG & Harrity JPA (2004) . Synlett(1), 140-142.
Moore JE, Spinks D & Harrity JPA (2004) . Tetrahedron Letters, 45(16), 3189-3191.
Moran WJ, Goodenough KM, Raubo P & Harrity JPA (2003) . Org Lett, 5(19), 3427-3429.
Hedley SJ, Moran WJ, Price DA & Harrity JPA (2003) . J Org Chem, 68(11), 4286-4292.
Carbery DR, Reignier S, Miller ND, Adams H & Harrity JPA (2003) . J Org Chem, 68(11), 4392-4399.
Edwards AS, Wybrow RAJ, Johnstone C, Adams H & Harrity JPA (2002) . Chem Commun (Camb)(14), 1542-1543.
Carbery DR, Miller ND & Harrity JPA (2002) . Chem Commun (Camb)(14), 1546-1547.
Carbery DR, Reignier S, Myatt JW, Miller ND & Harrity JPA (2002) . Angewandte Chemie, 114(14), 2696-2699.
Carbery DR, Reignier S, Myatt JW, Miller ND & Harrity JPA (2002) . Angew Chem Int Ed Engl, 41(14), 2584-2587.
Harrity JPA, Adams H, Davies MW, Wybrow RAJ & Johnson CN (2002) . Acta Crystallogr C, 58(Pt 3), o168-o169.
Moore JE, Goodenough KM, Spinks D & Harrity JPA (2002) . Synlett(12), 2071-2073.
Wybrow RAJ, Johnson LA, Auffray B, Moran WJ, Adams H & Harrity JPA (2002) . Tetrahedron Letters, 43(44), 7851-7854.
Davies MW, Wybrow RA, Johnson CN & Harrity JP (2001) . Chem Commun (Camb)(17), 1558-1559.
Davies MW, Johnson CN & Harrity JP (2001) . J Org Chem, 66(10), 3525-3532.
Hedley SJ, Moran WJ, Prenzel AHGP, Price DA & Harrity JPA (2001) . Synlett(10), 1596-1598.
Bassindale MJ, Hamley P & Harrity JPA (2001) . Tetrahedron Letters, 42(51), 9055-9057.
Bassindale MJ, Edwards AS, Hamley P, Adams H & Harrity JPA (2000) . Chemical Communications(12), 1035-1036.
Caldwell JJ, Harrity JPA, Heron NM, Kerr WJ, McKendry S & Middlemiss D (1999) . Tetrahedron Letters, 40(17), 3481-3484.
Bassindale MJ, Hamley P, Leitner A & Harrity JPA (1999) . Tetrahedron Letters, 40(16), 3247-3250.
Davies MW, Johnson CN & Harrity JPA (1999) . Chemical Communications(20), 2107-2108.
Kingsbury JS, Harrity JPA, Bonitatebus PJ & Hoveyda AH (1999) . Journal of the American Chemical Society, 121(4), 791-799.
Kingsbury JS, Harrity JPA & Hoveyda AH (1998) Preparation, characterization, and metathesis activity of a novel, recyclable ruthenium alkylidene complex.. ABSTR PAP AM CHEM S, 216, U393-U393.
Harrity JPA, La DS, Cefalo DR, Visser MS & Hoveyda AH (1998) . Journal of the American Chemical Society, 120(10), 2343-2351.
Harrity JPA, Kerr WJ, Middlemiss D & Scott JS (1997) . Journal of Organometallic Chemistry, 532(1-2), 219-227.
Harrity JPA, Visser MS, Gleason JD & Hoveyda AH (1997) . Journal of the American Chemical Society, 119(6), 1488-1489.
Visser MS, Harrity JPA & Hoveyda AH (1996) . Journal of the American Chemical Society, 118(15), 3779-3780.
Cole BM, Shimizu KD, Krueger CA, Harrity JPA, Snapper ML & Hoveyda AH (1996) . Angewandte Chemie (International Edition in English), 35(15), 1668-1671.
Harrity JPA, Heron NM, Kerr WJ, McKendry S, Middlemiss D & Scott JS (1996) . Synlett, 1996(12), 1184-1186.
Harrity JPA, Kerr WJ & Middlemiss D (1993) . Tetrahedron Letters, 34(18), 2995-2998.
Harrity JPA, Kerr WJ & Middlemiss D (1993) . Tetrahedron, 49(25), 5565-5576.
Han J, Gao W & Harrity JPA () . The Journal of Organic Chemistry.
Gao W, Han J, Greaves S & Harrity JPA () . Organic Letters.
Valdez Pérez LF, Bachollet SPJT, Orlov NV, Kopf KPM & Harrity JPA () . Angewandte Chemie.
Cousins DL, Lim YH & Harrity JPA () . The Journal of Organic Chemistry.
Zirimwabagabo J-O, Jailani ABA, Avgoustou P, Tozer MJ, Gibson KR, Glossop PA, Mills JEJ, Porter RA, Blaney P, Wang N , Skerry TM et al () . Journal of Medicinal Chemistry.
Harrity JPA, Cousins DL, Fricero P, Kopf KPM, McColl EJ, Czechtizky W & Lim YH () . Angewandte Chemie.
Harrity J & Al-Saedy M () . Synlett, 27(11), 1674-1676.
Nassoy A-CMA, Raubo P & Harrity JPA () . Chemical Communications, 51(27), 5914-5916.
Vivat J, Bachollet S, Adams H & Harrity J () . Molecules, 19(12), 21324-21334.

Patents

Richards G, Skerry T, Harrity J, Zirimwabagabo J-O, Tozer M, Porter R, Gibson K, Glossop P & Blaney P (2018) Compounds. WO2018/211275Al Appl. 16 May 2018.
Harrity J, Tazi-Ahnini R, Ward S, Cork M, Duff G & Bavik C () Aminoalkylimidazole Derivatives and their use in Medicine. Appl. 01 Jan 1970.

Teaching interests: Organic Chemistry

Teaching activities

Undergraduate and postgraduate taught modules

Introduction to organic synthesis 2 (Level 2)
This lecture course will discuss the α-functionalisation of carbonyl derivatives and related compounds. Specifically, alkylation and acylation reactions will be introduced and their applications in synthesis described. Simple examples highlighting chemoselective oxidation and reduction processes will also be discussed.
Aromatics in Synthesis (Level 3)
This course explores the react
Stereoselective Synthesis (Level 4)
This module gives a broad overview on current methods for controlling stereochemistry in organic synthesis. Key concepts in controlling relative and absolute stereochemistry will be introduced and illustrated.

Support Teaching:

Tutorials: Level 1 General Chemistry.

Laboratory Teaching:

Level 2 Organic Laboratories
Level 3 Organic Laboratories
Level 4 Research Project