Fletcher, Alexander, Dr

Dr Alexander Fletcher

School of Mathematical and Physical Sciences

School Director of Research and Innovation

Professor of Mathematical Biology

a.g.fletcher@sheffield.ac.uk
+44 114 222 3846

G15, Hicks Building

Full contact details

Dr Alexander Fletcher
School of Mathematical and Physical Sciences
G15
Hicks Building
Hounsfield Road
91ֱ��
S3 7RH

Profile

2022 - 2024: Senior Lecturer, School of Mathematics and Statistics, University of 91ֱ��
2019 - 2022: Lecturer, School of Mathematics and Statistics, University of 91ֱ��
2015 - 2019 : Vice-Chancellor's Fellow, School of Mathematics and Statistics, University of 91ֱ��
2011 - 2015 : Research Fellow in Computational Science, Mathematical Institute, University of Oxford
2008 - 2015 : Stipendiary Lecturer in Mathematics, St Hugh's College, University of Oxford
2008 - 2011 : Postdoctoral Research Assistant, Mathematical Institute, University of Oxford
2005 - 2010 : DPhil, Mathematical Institute, University of Oxford

Research interests: I develop and apply mathematical models to study complex biological systems. Techniques range from discrete and continuous models of temporal dynamics to more computationally intensive individual-based and multiscale simulations. Major applications include mechanisms underlying tissue homeostasis and their disruption in cancer formation and progression, and the orchestration of cell-level processes such as proliferation, death, adhesion and migration to give correct tissue-level proportions in embryos.

Publications

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Featured publications

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All publications

Journal articles

Cammarota C, Dawney NS, Bellomio PM, Jüng M, Fletcher AG, Finegan TM & Bergstralh DT (2024) . PLOS Computational Biology, 20(4), e1012001-e1012001.
Strawbridge SE, Kurowski A, Corujo-Simon E, Fletcher AN, Nichols J & Fletcher AG (2023) . Biology Open, 12(9).
Montes-Olivas S, Legge D, Lund A, Fletcher AG, Williams AC, Marucci L & Homer M (2023) . PLOS Computational Biology, 19(8).
Peifer M, Schmidt A, Finegan T, Häring M, Kong D, Fletcher AG, Alam Z, Grosshans J & Wolf F (2023) . Molecular Biology of the Cell, 34(8), ar81.
Cammarota C, Dawney NS, Bellomio PM, Jüng M, Fletcher AG, Finegan TM & Bergstralh DT (2023) .
Johnson CGM, Fletcher AG & Soyer OS (2022) . GigaScience, 11(2022).
Nestor-Bergmann A, Blanchard GB, Hervieux N, Fletcher AG, Étienne J & Sanson B (2022) . PLoS Computational Biology, 18(1).
Niehus R, Oliveira NM, Li A, Fletcher AG & Foster KR (2021) . eLife, 10.
Gonay L, Spourquet C, Baudoin M, Lepers L, Lemoine P, Fletcher AG, Hanert E & Pierreux CE (2021) . Frontiers in Endocrinology, 12.
Fletcher AG & Osborne JM (2021) . WIREs Mechanisms of Disease.
Groves I, Placzek M & Fletcher AG (2020) . Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1809).
Campbell K, Noël ES, Fletcher AG & Bulgakova NA (2020) . Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1809).
Gorochowski TE, Hauert S, Kreft J-U, Marucci L, Stillman NR, Tang T-YD, Bandiera L, Bartoli V, Dixon DOR, Fedorec AJH , Fellermann H et al (2020) . Frontiers in Bioengineering and Biotechnology, 8.
Ruske LJ, Kursawe J, Tsakiridis A, Wilson V, Fletcher A, Blythe RA & Schumacher LJ (2020) . Physical Biology.
Cooper F, Baker R, Bernabeu M, Bordas R, Bowler L, Bueno-Orovio A, Byrne H, Carapella V, Cardone-Noott L, Cooper J , Dutta S et al (2020) . Journal of Open Source Software, 5(47), 1848-1848.
Grimes DR & Fletcher AG (2020) . Bulletin of Mathematical Biology, 82(2).
Ward D, Montes Olivas S, Fletcher A, Homer M & Marucci L (2020) . Computational and Structural Biotechnology Journal, 18, 230-240.
Finegan TM, Hervieux N, Nestor-Bergmann A, Fletcher AG, Blanchard GB & Sanson B (2019) . PLOS Biology, 17(12).
Cooper RL, Lloyd VJ, Di-Poï N, Fletcher AG, Barrett PM & Fraser GJ (2019) . EvoDevo, 10(1).
Scott JG, Maini PK, Anderson ARA & Fletcher AG (2019) . Systematic Biology, 0, 1-41.
Blanchard GB, Fletcher AG & Schumacher LJ (2019) . Seminars in Cell and Developmental Biology, 93, 46-54.
Fisher KH, Strutt D & Fletcher AG (2019) . iScience, 17, 49-66.
Baker A-M, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G, McDonald SAC, Wright NA , Simons BD et al (2019) . Cell Reports, 27(8), 2524-2524.
Scott JG, Dhawan A, Hjelmeland A, Lathia J, Chumakova A, Hitomi M, Fletcher AG, Maini PK & Anderson ARA (2019) . Current Stem Cell Reports, 5(1), 22-30.
Parker A, Vaux L, Patterson AM, Modasia A, Muraro D, Fletcher AG, Byrne HM, Maini PK, Watson AJM & Pin C (2019) . Cell Death & Disease, 10.
Finegan TM, Na D, Cammarota C, Skeeters AV, Nádasi TJ, Dawney NS, Fletcher AG, Oakes PW & Bergstralh DT (2018) . EMBO Journal, 38(3).
Cooper R, Thiery A, Fletcher AG, Delbarre D, Rasch L & Fraser G (2018) . Science Advances, 4(11).
Muraro D, Parker A, Vaux L, Filippi S, Almet AA, Fletcher AG, Watson AJM, Pin C, Maini PK & Byrne HM (2018) . Interface, 15(145).
Lambert B, MacLean AL, Fletcher AG, Combes AN, Little MH & Byrne HM (2018) . Journal of Mathematical Biology, 76(7), 1673-1697.
Kursawe J, Baker RE & Fletcher AG (2018) . Journal of Theoretical Biology, 443, 66-81.
Cooper F, Baker RE & Fletcher AG (2017) . SIAM Journal on Scientific Computing, 39(5), B943-B967.
Fisher KH, Strutt D & Fletcher AG (2017) . Current Opinion in Systems Biology, 5, 41-49.
Kursawe J, Baker RE & Fletcher AG (2017) . Journal of Computational Physics, 345, 752-767.
Maclaren OJ, Parker A, Pin C, Carding SR, Watson AJM, Fletcher AG, Byrne HM & Maini PK (2017) . PLoS Computational Biology, 13(7).
Bucksch A, Atta-Boateng A, Azihou AF, Battogtokh D, Baumgartner A, Binder BM, Braybrook SA, Chang C, Coneva V, DeWitt TJ , Fletcher AG et al (2017) . Frontiers in Plant Science, 8.
Fletcher AG, Cooper F & Baker RE (2017) . Philosophical Transactions of the Royal Society B: Biological Sciences, 372(1720).
Osborne JM, Fletcher AG, Pitt-Francis JM, Maini PK & Gavaghan DJ (2017) . PLoS Computational Biology, 13(2).
Godwin S, Ward D, Pedone E, Homer M, Fletcher AG & Marucci L (2017) . npj Systems Biology and Applications, 3(1).
Kursawe J, Bardenet R, Zartman JJ, Baker RE & Fletcher AG (2016) . Interface, 13(124).
Tetley RJ, Blanchard GB, Fletcher AG, Adams RJ & Sanson B (2016) . eLife, 5.
Dhawan A, Graham TA & Fletcher AG (2016) . Cancer Prevention Research, 9(4), 283-295.
Fletcher AG, Murray PJ & Maini PK (2015) . Mathematical Models and Methods in Applied Sciences, 25(13), 2563-2585.
Niehus R, Mitri S, Fletcher AG & Foster KR (2015) . Nature Communications, 6(1).
Nichol D, Jeavons P, Fletcher AG, Bonomo RA, Maini PK, Paul JL, Gatenby RA, Anderson ARA & Scott JG (2015) . PLoS Computational Biology, 11(9).
Harvey DG, Fletcher AG, Osborne JM & Pitt-Francis J (2015) . Computer Physics Communications, 192, 130-137.
Maclaren OJ, Byrne HM, Fletcher AG & Maini PK (2015) . Mathematical Biosciences and Engineering, 12(6), 1321-1340.
Grimes DR, Fletcher AG & Partridge M (2014) . Royal Society Open Science, 1(1), 140080-140080.
Baker A-M, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G, McDonald SAC, Wright NA , Simons BD et al (2014) . Cell Reports, 8(4), 940-947.
Rosser G, Baker RE, Armitage JP & Fletcher AG (2014) . Journal of The Royal Society Interface, 11(97), 20140320-20140320.
Fletcher AG, Osterfield M, Baker RE & Shvartsman SY (2014) . Biophysical Journal, 106(11), 2291-2304.
Bloch K, Smith H, Hamel Parsons V, Gavaghan D, Kelly C, Fletcher A, Maini P & Callaghan R (2014) . Cell Biochemistry and Biophysics, 68(3), 615-628.
Scott JG, Fletcher AG, Maini PK, Anderson ARA & Gerlee P (2014) . European Journal of Cancer, 50(17), 3068-3075.
Fletcher AG, Osborne JM, Maini PK & Gavaghan DJ (2013) . Progress in Biophysics and Molecular Biology, 113(2), 299-326.
Vincent J-P, Fletcher AG & Baena-Lopez LA (2013) . Nature Reviews Molecular Cell Biology, 14(9), 581-591.
Rosser G, Fletcher AG, Maini PK & Baker RE (2013) . Journal of the Royal Society Interface, 10(85).
Lloyd-Lewis B, Fletcher AG, Dale TC & Byrne HM (2013) . Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 5(4), 391-407.
Mirams GR, Fletcher AG, Maini PK & Byrne HM (2012) . Journal of Theoretical Biology, 312, 143-156.
Dello Ioio R, Galinha C, Fletcher AG, Grigg SP, Molnar A, Willemsen V, Scheres B, Sabatini S, Baulcombe D, Maini PK & Tsiantis M (2012) . Current Biology, 22(18), 1699-1704.
Fletcher AG, Breward CJW & Jonathan Chapman S (2012) . Journal of Theoretical Biology, 300, 118-133.
Dunn S-J, Fletcher AG, Chapman SJ, Gavaghan DJ & Osborne JM (2012) . Journal of Theoretical Biology, 298, 82-91.
Murray PJ, Walter A, Fletcher AG, Edwards CM, Tindall MJ & Maini PK (2011) . Physical Biology, 8(2), 026011-026011.
Osborne JM, Walter A, Kershaw SK, Mirams GR, Fletcher AG, Pathmanathan P, Gavaghan D, Jensen OE, Maini PK & Byrne HM (2010) . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 368(1930), 5013-5028.
van Leeuwen IMM, Mirams GR, Walter A, Fletcher A, Murray P, Osborne J, Varma S, Young SJ, Cooper J, Doyle B , Pitt-Francis J et al (2009) . Cell Proliferation, 42(5), 617-636.
Pitt-Francis J, Pathmanathan P, Bernabeu MO, Bordas R, Cooper J, Fletcher AG, Mirams GR, Murray P, Osborne JM, Walter A , Chapman SJ et al (2009) . Computer Physics Communications, 180(12), 2452-2471.
Groves I, Holmshaw J, Furley D, Manning E, Chinnaiya K, Towers M, Evans BD, Placzek M & Fletcher AG () . Development.
Scott JG, Fletcher AG, Anderson ARA & Maini PK () . PLOS Computational Biology, 12(1), e1004712-e1004712.
Kursawe J, Brodskiy PA, Zartman JJ, Baker RE & Fletcher AG () . PLOS Computational Biology, 11(12), e1004679-e1004679.
Narciso C, Wu Q, Brodskiy P, Garston G, Baker R, Fletcher A & Zartman J () . Physical Biology, 12(5), 056005-056005.
Bright S, Fletcher AG, Fell D & Kadhim MA () .
Kursawe J, Brodskiy PA, Zartman JJ, Baker RE & Fletcher AG () .
Knapp B, Bardenet R, Bernabeu MO, Bordas R, Bruna M, Calderhead B, Cooper J, Fletcher AG, Groen D, Kuijper B , Lewis J et al () . PLOS Computational Biology, 11(4), e1004214-e1004214.
Rosser G, Baker RE, Armitage JP & Fletcher AG () .
Osborne JM, Bernabeu MO, Bruna M, Calderhead B, Cooper J, Dalchau N, Dunn S-J, Fletcher AG, Freeman R, Groen D , Knapp B et al () . PLoS Computational Biology, 10(3), e1003506-e1003506.
Rosser G, Fletcher AG, Wilkinson DA, de Beyer JA, Yates CA, Armitage JP, Maini PK & Baker RE () . PLoS Computational Biology, 9(10), e1003276-e1003276.
Mirams GR, Arthurs CJ, Bernabeu MO, Bordas R, Cooper J, Corrias A, Davit Y, Dunn S-J, Fletcher AG, Harvey DG , Marsh ME et al () . PLoS Computational Biology, 9(3), e1002970-e1002970.
Pathmanathan P, Cooper J, Fletcher A, Mirams G, Murray P, Osborne J, Pitt-Francis J, Walter A & Chapman SJ () . Physical Biology, 6(3), 036001-036001.
Friedman SH, Anderson ARA, Bortz DM, Fletcher AG, Frieboes HB, Ghaffarizadeh A, Grimes DR, Hawkins-Daarud A, Hoehme S, Juarez EF , Kesselman C et al () .
Parker A, Maclaren OJ, Fletcher AG, Muraro D, Kreuzaler PA, Byrne HM, Maini PK, Watson AJM & Pin C () . FASEB Journal.

Chapters

Scott JG, Gerlee P, Basanta D, Fletcher AG, Maini PK & Anderson ARA (2013) , Experimental Metastasis: Modeling and Analysis (pp. 189-208). Springer Netherlands
() CRC Press

Conference proceedings papers

Parker A, Maclaren O, Watson A, Byrne H, Fletcher A, Carding S, Maini P & Pin C (2014) A multidisciplinary approach to studying crypt-villus homeostasis and regeneration in the intestinal epithelium. FEBS JOURNAL, Vol. 281 (pp 217-218)

Preprints

Strawbridge SE, Schrattel AK, Humphreys P, Jones KA, Artus J, Hadjantonakis A-K, Fletcher AG & Nichols J (2024) , Cold Spring Harbor Laboratory.
Schmidt A, Finegan T, Häring M, Kong D, Fletcher AG, Alam Z, Grosshans J, Wolf F & Peifer M (2023) , Cold Spring Harbor Laboratory.
Montes-Olivas S, Legge D, Lund A, Fletcher AG, Williams AC, Marucci L & Homer M (2022) , Cold Spring Harbor Laboratory.
Fletcher A & Osborne J (2020) , MDPI AG.
Gorochowski TE, Hauert S, Kreft J-U, Marucci L, Stillman NR, Tang T-YD, Bandiera L, Bartoli V, Dixon DOR, Fedorec AJH , Fellermann H et al (2020) , MDPI AG.
Ruske LJ, Kursawe J, Tsakiridis A, Wilson V, Fletcher AG, Blythe RA & Schumacher LJ (2020) Coupled differentiation and division of embryonic stem cells inferred from clonal snapshots, arXiv.
Fletcher AG, Murray PJ & Maini PK (2015) , arXiv.
Maclaren OJ, Fletcher AG, Byrne HM & Maini PK (2015) , arXiv.
Scott JG, Fletcher AG, Maini PK, Anderson ARA & Gerlee P (2013) , arXiv.
Scott JG, Gerlee P, Basanta D, Fletcher AG, Maini PK & Anderson AR (2013) , arXiv.
Groves I, Holmshaw J, Furley D, Evans BD, Placzek M & Fletcher AG () , Cold Spring Harbor Laboratory.
Strawbridge SE, Kurowski A, Corujo-Simon E, Fletcher AG & Nichols J () , Cold Spring Harbor Laboratory.
Johnson CGM, Fletcher AG & Soyer OS () , Cold Spring Harbor Laboratory.
Cammarota CM, Dawney NS, Jia Q, Jüng MM, Glichowski JA, Bellomio PM, Fletcher AG & Bergstralh DT () , Cold Spring Harbor Laboratory.
Nestor-Bergmann A, Blanchard GB, Hervieux N, Fletcher AG, Étienne J & Sanson B () , Cold Spring Harbor Laboratory.
Finegan TM, Hervieux N, Nestor-Bergmann A, Fletcher AG, Blanchard GB & Sanson B () .
Ward D, Fletcher AG, Homer M & Marucci L () .
Scott JG, Maini PK, Anderson ARA & Fletcher AG () .
Muraro D, Parker A, Vaux L, Filippi S, Fletcher AG, Watson AJ, Pin C, Maini PK & Byrne HM () , Cold Spring Harbor Laboratory.
Fisher KH, Strutt D & Fletcher AG () .
Kursawe J, Baker RE & Fletcher AG () , Cold Spring Harbor Laboratory.
Lambert B, MacLean AL, Fletcher AG, Combes AN, Little MH & Byrne HM () , Cold Spring Harbor Laboratory.
Friedman SH, Anderson ARA, Bortz DM, Fletcher AG, Frieboes HB, Ghaffarizadeh A, Grimes DR, Hawkins-Daarud A, Hoehme S, Juarez EF , Kesselman C et al () .
Kursawe J, Baker RE & Fletcher AG () , Cold Spring Harbor Laboratory.
Mullinax J, O’Farrelly C, Scott JG, Buttenschön A, Elkenawi AE, Moustaid FE, Fletcher AG, Grassberger C, Kim E, Marusyk A , McClelland HLO et al () .
Brodskiy PA, Eberts PM, Narciso C, Kursawe J, Fletcher A & Zartman JJ () .
Bucksch A, Atta-Boateng A, Azihou AF, Balduzzi M, Battogtokh D, Baumgartner A, Binder BM, Braybrook SA, Chang C, Coneva V , DeWitt TJ et al () , Cold Spring Harbor Laboratory.
Osborne JM, Fletcher AG, Pitt-Francis JM, Maini PK & Gavaghan DJ () , Cold Spring Harbor Laboratory.
Maclaren OJ, Parker A, Pin C, Carding SR, Watson AJM, Fletcher AG, Byrne HM & Maini PK () , Cold Spring Harbor Laboratory.
Cooper FR, Baker RE & Fletcher AG () , Cold Spring Harbor Laboratory.
Kursawe J, Bardenet R, Zartman JJ, Baker RE & Fletcher AG () , Cold Spring Harbor Laboratory.
Scott JG, Fletcher AG, Anderson ARA & Maini PK () , Cold Spring Harbor Laboratory.
Dhawan A, Graham TA & Fletcher AG () , Cold Spring Harbor Laboratory.
Nichol D, Jeavons P, Fletcher AG, Bonomo RA, Maini PK, Paul JL, Gatenby RA, Anderson ARA & Scott JG () , Cold Spring Harbor Laboratory.
Scott JG, Fletcher AG, Maini PK, Anderson ARA & Gerlee P () , Cold Spring Harbor Laboratory.

Research group

Grants

Current grants, as Principal Investigator:
Inferring epithelial tissue mechanics through data-efficient multi-fidelity modelling BBSRC
Understanding self-organised tissue patterning across scales EPSRC
Chaste: developing sustainable software for computational biology BBSRC
Current grants, as Coinvestigator:
Hypothalamic development from self-organising progenitors Wellcome Trust
Past grants, as Coinvestigator:
How do the atypical cadherins Fat and Dachsous integrate growth and patterning during development? BBSRC

Teaching activities

MAS116	Mathematical Investigation Skills
MAS2007	Mathematics and Statistics in Action

91ֱ��

School of Mathematical and Physical Sciences

School of Mathematical and Physical Sciences

Dr Alexander Fletcher

Featured publications

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Journal articles

Chapters

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Preprints

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