Dr Freek van Eeden

School of Biosciences

Senior Lecturer

f.j.vaneeden@sheffield.ac.uk
+44 114 222 2348

Full contact details

Dr Freek van Eeden
School of Biosciences
C13
Firth Court
Western Bank
91直播
S10 2TN
Profile
  • 2006- present: Senior Lecturer, University of 91直播
  • 1999 - 2005: Junior Group Leader Hubrecht Laboratory, Utrecht, The Netherlands
  • 1997 - 1999: Post-doctoral worker, D. StJohnston Lab, Wellcome/CRC Inst. Cambridge UK
  • 1992 - 1997: PhD, C. N眉sslein-Volhard Lab. Max Planck Inst. f眉r Entwicklungsbiologie, T眉bingen, Germany
  • 1986 - 1992 MSc. Wageningen Agricultural University, The Netherlands
Research interests

Using the zebrafish as a genetic tool to study development and disease. We are interested in understanding the role of the patched genes in Hedgehog signaling. In addition, we have created a knockout for the von Hippel Lindau disease (VHL) gene and are interested in modeling VHL deficient cancers in zebrafish.

Understanding VHL and hypoxic signalling in Cancer

The zebrafish provides a powerful organism to model human development and disease.  We are exploiting and developing the zebrafish, e.g. by creating such disease models, by using knockout technology like CRISPR, or by looking for chemicals that can modify disease-relevant phenotypes.

One of our current projects, models the human Von Hippel Lindau disease,  caused  by mutation of the VHL gene. VHL is a negative regulator of the Hypoxia Inducible Factor (HIF) signalling pathway, which is vital for development and survival of many tumours. However, this is not the only function of VHL and over the years numerous others have been identified. We found that in zebrafish, the functions of human VHL have been split over two genes, which we named vhl and vhl-like (vll).

Interestingly, we found that the fish vhl gene has an important role in HIF regulation, as mutants we made by reverse genetics show all hallmarks of an inappropriate hypoxic response under normoxic conditions. The role of vll was initially enigmatic, null mutants that we created in this gene were viable and fertile. However, using a unique and novel in vivo reporter for genome stability that we created, we discovered that the vll gene is important for maintaining genome stability, which is a major driver for tumour initiation. This is what we are currently trying to understand better.

Current collaborations: Sherif El-Khamisy (genome stability), Albert Ong (pkd2 model), Jane McKeating (Birmingham), Francesco Argenton (Padua) (both glucocorticoid-HIF interaction).

Publications

Show: Featured publications All publications

Journal articles

  • Baranasic D, H枚rtenhuber M, Balwierz PJ, Zehnder T, Mukarram AK, Nepal C, V谩rnai C, Hadzhiev Y, Jimenez-Gonzalez A, Li N , Wragg J et al (2022) . Nature Genetics, 54(7), 1037-1050. RIS download Bibtex download
  • Leventea E, Zhu Z, Fang X, Nikolaeva Y, Markham E, Hirst RA, Van Eeden F & Malicki J (2021) . Proceedings of the National Academy of Sciences, 118(28). RIS download Bibtex download
  • Fang X, Peden AA, van Eeden FJM & Malicki JJ (2021) . Journal of Cell Science, 134(6). RIS download Bibtex download
  • Zaksauskaite R, Thomas RC, van Eeden F & El-Khamisy SF (2021) . Science Advances, 7(5). RIS download Bibtex download
  • Vettori A, Greenald D, Wilson GK, Peron M, Facchinello N, Markham E, Sinnakaruppan M, Matthews LC, McKeating JA, Argenton F & van Eeden FJM (2017) . Proceedings of the National Academy of Sciences, 114(37), 9948-9953. RIS download Bibtex download
  • Wilkinson RN, Elworthy S, Ingham PW & van Eeden FJM (2017) . BioTechniques, 62(1). RIS download Bibtex download
  • Greenald D, Jeyakani J, Pelster B, Sealy I, Mathavan S & van Eeden FJ (2015) . BMC Genomics, 16(1). RIS download Bibtex download
  • Wilkinson RN, Elworthy S, Ingham PW & van Eeden FJM (2013) . Biotechniques, 55(6), 314-316. RIS download Bibtex download
  • Watson O, Novodvorsky P, Gray C, Rothman AMK, Lawrie A, Crossman DC, Haase A, McMahon K, Gering M, Van Eeden FJM & Chico TJA (2013) . Cardiovasc Res, 100(2), 252-261. RIS download Bibtex download
  • Kettleborough RN, Busch-Nentwich EM, Harvey SA, Dooley CM, de Bruijn E, van Eeden F, Sealy I, White RJ, Herd C, Nijman IJ , F茅nyes F et al (2013) . Nature, 496, 494-497. RIS download Bibtex download
  • Santhakumar K, Judson EC, Elks PM, McKee S, Elworthy S, van Rooijen E, Walmsley SS, Renshaw SA, Cross SS & van Eeden FJM (2012) . Cancer Res, 72(16), 4017-4027. RIS download Bibtex download
  • Elks PM, van Eeden FJ, Dixon G, Wang X, Reyes-Aldasoro CC, Ingham PW, Whyte MKB, Walmsley SR & Renshaw SA (2011) . Blood, 118(3), 712-722. RIS download Bibtex download
  • van Eeden FJ, Granato M, Schach U, Brand M, Furutani-Seiki M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ, Kane DA , Kelsh RN et al (1996) Mutations affecting somite formation and patterning in the zebrafish, Danio rerio.. Development, 123, 153-164. RIS download Bibtex download

All publications

Journal articles

  • Baranasic D, H枚rtenhuber M, Balwierz PJ, Zehnder T, Mukarram AK, Nepal C, V谩rnai C, Hadzhiev Y, Jimenez-Gonzalez A, Li N , Wragg J et al (2022) . Nature Genetics, 54(7), 1037-1050. RIS download Bibtex download
  • Marchi D & Van Eeden F (2021) . Cells, 10(12). RIS download Bibtex download
  • Shafique F, Ali S, Almansouri TS, Eeden FV, Shafi N, Khalid M, Khawaja S, Andleeb S & Hassan M (2021) . Brazilian Journal of Biology, 83. RIS download Bibtex download
  • Leventea E, Zhu Z, Fang X, Nikolaeva Y, Markham E, Hirst RA, Van Eeden F & Malicki J (2021) . Proceedings of the National Academy of Sciences, 118(28). RIS download Bibtex download
  • Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, No毛l ES & Serbanovic鈥怌anic J (2021) . British Journal of Pharmacology. RIS download Bibtex download
  • Fang X, Peden AA, van Eeden FJM & Malicki JJ (2021) . Journal of Cell Science, 134(6). RIS download Bibtex download
  • Zaksauskaite R, Thomas RC, van Eeden F & El-Khamisy SF (2021) . Science Advances, 7(5). RIS download Bibtex download
  • Kim HR, Santhakumar K, Markham E, Baldera D, Greenald D, Bryant HE, El-Khamisy SF & van Eeden FJ (2020) . Oncotarget, 11(13), 1109-1130. RIS download Bibtex download
  • Plant T, Eamsamarng S, Sanchez-Garcia MA, Reyes L, Renshaw SA, Coelho P, Mirchandani AS, Morgan J-M, Ellett FE, Morrison T , Humphries D et al (2020) . Journal of Clinical Investigation. RIS download Bibtex download
  • Metzner A, Griffiths JD, Streets AJ, Markham E, Philippou T, Van Eeden FJM & Ong ACM (2020) . Scientific Reports, 10(1). RIS download Bibtex download
  • Arhatte M, Gunaratne GS, Boustany CE, Kuo IY, Moro C, Duprat F, Plaisant M, Duval H, Li D, Picard N , Couvreux A et al (2019) . Nature Communications, 10(1). RIS download Bibtex download
  • Savage AM, Kurusamy S, Chen Y, Jiang Z, Chhabria K, MacDonald RB, Kim HR, Wilson HL, van Eeden FJM, Armesilla AL , Chico TJA et al (2019) . Nature Communications, 10. RIS download Bibtex download
  • Cayuela ML, B.M. Klaes K, Godinho Ferreira M, Henriques CM, Van Eeden F, Varga M, Vierstraete J & Mione MC (2019) . Frontiers in Cell and Developmental Biology, 6. RIS download Bibtex download
  • van聽Rooijen E, van聽de聽Hoek G, Logister I, Ajzenberg H, Knoers NVAM, van聽Eeden F, Voest EE, Schulte-Merker S & Giles RH (2018) . Nephron, 138(4), 310-323. RIS download Bibtex download
  • Pickering J, Cunliffe VT, Van Eeden F & Borycki A-G (2017) . Matrix Biology, 62, 58-74. RIS download Bibtex download
  • Carre帽o Guti茅rrez H, O鈥橪eary A, Freudenberg F, Fedele G, Wilkinson R, Markham E, van Eeden F, Reif A & Norton WHJ (2017) . European Neuropsychopharmacology. RIS download Bibtex download
  • Vettori A, Greenald D, Wilson GK, Peron M, Facchinello N, Markham E, Sinnakaruppan M, Matthews LC, McKeating JA, Argenton F & van Eeden FJM (2017) . Proceedings of the National Academy of Sciences, 114(37), 9948-9953. RIS download Bibtex download
  • Baxendale S, van Eeden F & Wilkinson R (2017) , 179-197. RIS download Bibtex download
  • Wilkinson RN, Elworthy S, Ingham PW & van Eeden FJM (2017) . BioTechniques, 62(1). RIS download Bibtex download
  • Valentim AM, Eeden FJ, Str盲hle U & Olsson IAS (2016) . EMBO reports, 17(12), 1688-1689. RIS download Bibtex download
  • Kim HR, Greenald D, Vettori A, Markham E, Santhakumar K, Argenton F & van Eeden F (2016) . Methods in Cell Biology. RIS download Bibtex download
  • Njegic AM, Chico TJA, van Eeden FJ & Watson OJ (2015) . Atherosclerosis, 244, E8-E9. RIS download Bibtex download
  • Greenald D, Jeyakani J, Pelster B, Sealy I, Mathavan S & van Eeden FJ (2015) . BMC Genomics, 16(1). RIS download Bibtex download
  • Elks PM, Renshaw SA, Meijer AH, Walmsley SR & van Eeden FJ (2015) . Disease Models & Mechanisms, 8(11), 1349-1360. RIS download Bibtex download
  • Elks PM, van der Vaart M, Walmsley SR, van Eeden FJ, Spaink HP, Meijer AH & Renshaw SA (2014) Hypoxic signalling modulates neutrophil nitric oxide in a zebrafish tuberculosis model. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 44, 12-12. RIS download Bibtex download
  • Wilkinson RN & van Eeden FJM (2014) . Prog Mol Biol Transl Sci, 124, 93-122. RIS download Bibtex download
  • Wilkinson RN, Jopling C & van Eeden FJM (2014) . Prog Mol Biol Transl Sci, 124, 65-91. RIS download Bibtex download
  • Maurya AK, Ben J, Zhao Z, Lee RTH, Niah W, Ng ASM, Iyu A, Yu W, Elworthy S, van Eeden FJM & Ingham PW (2013) . PLoS Genet, 9(12), e1003955. RIS download Bibtex download
  • Elks PM, Brizee S, van der Vaart M, Walmsley SR, van Eeden FJ, Renshaw SA & Meijer AH (2013) . PLoS Pathog, 9(12), e1003789. RIS download Bibtex download
  • Wilkinson RN, Elworthy S, Ingham PW & van Eeden FJM (2013) . Biotechniques, 55(6), 314-316. RIS download Bibtex download
  • Watson O, Novodvorsky P, Gray C, Rothman AMK, Lawrie A, Crossman DC, Haase A, McMahon K, Gering M, Van Eeden FJM & Chico TJA (2013) . Cardiovasc Res, 100(2), 252-261. RIS download Bibtex download
  • Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian Y-M, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A , Demetriades M et al (2013) . ACS Chem Biol, 8(7), 1488-1496. RIS download Bibtex download
  • Kettleborough RN, Busch-Nentwich EM, Harvey SA, Dooley CM, de Bruijn E, van Eeden F, Sealy I, White RJ, Herd C, Nijman IJ , F茅nyes F et al (2013) . Nature, 496, 494-497. RIS download Bibtex download
  • Basten SG, Davis EE, Gillis AJM, van Rooijen E, Stoop H, Babala N, Logister I, Heath ZG, Jonges TN, Katsanis N , Voest EE et al (2013) . PLoS Genet, 9(4), e1003384. RIS download Bibtex download
  • Thompson AAR, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE , Formenti F et al (2013) . Blood, 123(3), 366-376. RIS download Bibtex download
  • Wilkinson RN, Koudijs MJ, Patient RK, Ingham PW, Schulte-Merker S & van Eeden FJM (2012) . Blood, 120(2), 477-488. RIS download Bibtex download
  • Santhakumar K, Judson EC, Elks PM, McKee S, Elworthy S, van Rooijen E, Walmsley SS, Renshaw SA, Cross SS & van Eeden FJM (2012) . Cancer Res, 72(16), 4017-4027. RIS download Bibtex download
  • Dooley CM, Kettleborough RN, Busch-Nentwich EM, Harvey SA, de Bruijn E, van Eeden F, Sealy I, White RJ, Scahill C, Herd C , Nijman IJ et al (2012) A systematic genome-wide knockout generation and analysis of zebrafish protein-coding gene function.. MOLECULAR BIOLOGY OF THE CELL, 23. RIS download Bibtex download
  • Sapetto-Rebow B, McLoughlin SC, O'Shea LC, O'Leary O, Willer JR, Alvarez Y, Collery R, O'Sullivan J, Van Eeden F, Hensey C & Kennedy BN (2011) . BMC Dev Biol, 11, 71. RIS download Bibtex download
  • Ben J, Elworthy S, Ng ASM, van Eeden F & Ingham PW (2011) . Development, 138(22), 4969-4978. RIS download Bibtex download
  • Elks PM, van Eeden FJ, Dixon G, Wang X, Reyes-Aldasoro CC, Ingham PW, Whyte MKB, Walmsley SR & Renshaw SA (2011) . Blood, 118(3), 712-722. RIS download Bibtex download
  • Renshaw SA, Elks P, Dixon G, Wang X, Ingham PW, van Eeden FJ, Whyte M & Walmsley SR (2011) . B36. AIRWAY IMMUNE MECHANISMS AND INFLAMMATION: ANIMAL MODELS. RIS download Bibtex download
  • Kettleborough RNW, de Bruijn E, van Eeden F, Cuppen E & Stemple DL (2011) . ZEBRAFISH: GENETICS, GENOMICS AND INFORMATICS, 3RD EDITION, 104, 121-127. RIS download Bibtex download
  • van Rooijen E, Santhakumar K, Logister I, Voest E, Schulte-Merker S, Giles R & van Eeden F (2011) , 105, 163-190. RIS download Bibtex download
  • van Rooijen E, Voest EE, Logister I, Bussmann J, Korving J, van Eeden FJ, Giles RH & Schulte-Merker S (2010) . Development, 137(11), e1106-e1106. RIS download Bibtex download
  • van Rooijen E, Voest EE, Logister I, Bussmann J, Korving J, van Eeden FJ, Giles RH & Schulte-Merker S (2010) . Dis Model Mech, 3(5-6), 343-353. RIS download Bibtex download
  • Hammond KL, van Eeden FJM & Whitfield TT (2010) . Development, 137(8), 1361-1371. RIS download Bibtex download
  • Kim HR, Richardson J, van Eeden F & Ingham PW (2010) . BMC Biol, 8, 65. RIS download Bibtex download
  • van Rooijen E, Voest EE, Logister I, Korving J, Schwerte T, Schulte-Merker S, Giles RH & van Eeden FJ (2009) . Blood, 113(25), 6449-6460. RIS download Bibtex download
  • Thomas NA, Koudijs M, van Eeden FJM, Joyner AL & Yelon D (2008) . Development, 135(22), 3789-3799. RIS download Bibtex download
  • van Rooijen E, Giles RH, Voest EE, van Rooijen C, Schulte-Merker S & van Eeden FJ (2008) . J Am Soc Nephrol, 19(6), 1128-1138. RIS download Bibtex download
  • Koudijs MJ, den Broeder MJ, Groot E & van Eeden FJ (2008) . BMC Dev Biol, 8, 15. RIS download Bibtex download
  • Kno虉ll R, Postel R, Kra虉tzner R, Hennecke G, Vacaru AM, Vakeel P, Kno虉ll G, Scha虉fer K, Bos E, Hertog JD , Peters PJ et al (2007) . Circulation, 116(suppl_16). RIS download Bibtex download
  • Kn枚ll R, Postel R, Wang J, Kr盲tzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK , Kube D et al (2007) . Circulation, 116(5), 515-525. RIS download Bibtex download
  • Guryev V, Koudijs MJ, Berezikov E, Johnson SL, Plasterk RHA, van Eeden FJM & Cuppen E (2006) . Genome Res, 16(4), 491-497. RIS download Bibtex download
  • Koudijs MJ, den Broeder MJ, Keijser A, Wienholds E, Houwing S, van Rooijen EMHC, Geisler R & van Eeden FJM (2005) . PLoS Genet, 1(2), e19. RIS download Bibtex download
  • Kennedy BN, Stearns GW, Smyth VA, Ramamurthy V, van Eeden F, Ankoudinova I, Raible D, Hurley JB & Brockerhoff SE (2004) . Dev Biol, 270(2), 336-349. RIS download Bibtex download
  • Wienholds E, van Eeden F, Kosters M, Mudde J, Plasterk RHA & Cuppen E (2003) . Genome Res, 13(12), 2700-2707. RIS download Bibtex download
  • Wienholds E, Koudijs MJ, van Eeden FJM, Cuppen E & Plasterk RHA (2003) . Nat Genet, 35(3), 217-218. RIS download Bibtex download
  • Hurlstone AFL, Haramis A-PG, Wienholds E, Begthel H, Korving J, Van Eeden F, Cuppen E, Zivkovic D, Plasterk RHA & Clevers H (2003) . Nature, 425(6958), 633-637. RIS download Bibtex download
  • van der Sar AM, Musters RJP, van Eeden FJM, Appelmelk BJ, Vandenbroucke-Grauls CMJE & Bitter W (2003) . Cell Microbiol, 5(9), 601-611. RIS download Bibtex download
  • van Eeden FJ, Palacios IM, Petronczki M, Weston MJ & St Johnston D (2001) . J Cell Biol, 154(3), 511-523. RIS download Bibtex download
  • Odenthal J, van Eeden FJ, Haffter P, Ingham PW & N眉sslein-Volhard C (2000) . Dev Biol, 219(2), 350-363. RIS download Bibtex download
  • van Eeden F & St Johnston D (1999) . Curr Opin Genet Dev, 9(4), 396-404. RIS download Bibtex download
  • van Eeden FJ, Granato M, Odenthal J & Haffter P (1999) . Methods Cell Biol, 60, 21-41. RIS download Bibtex download
  • Chandrasekhar A, Warren JT, Takahashi K, Schauerte HE, van Eeden FJ, Haffter P & Kuwada JY (1998) . Mech Dev, 76(1-2), 101-115. RIS download Bibtex download
  • Schauerte HE, van Eeden FJ, Fricke C, Odenthal J, Str盲hle U & Haffter P (1998) Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish.. Development, 125(15), 2983-2993. RIS download Bibtex download
  • Lauderdale JD, Pasquali SK, Fazel R, van Eeden FJ, Schauerte HE, Haffter P & Kuwada JY (1998) . Mol Cell Neurosci, 11(4), 194-205. RIS download Bibtex download
  • van Eeden FJM, Granato M, Odenthal J & Haffter P (1998) , 21-41. RIS download Bibtex download
  • van Eeden FJ, Holley SA, Haffter P & N眉sslein-Volhard C (1998) Zebrafish segmentation and pair-rule patterning.. Dev Genet, 23(1), 65-76. RIS download Bibtex download
  • Chen JN, van Eeden FJ, Warren KS, Chin A, N眉sslein-Volhard C, Haffter P & Fishman MC (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish.. Development, 124(21), 4373-4382. RIS download Bibtex download
  • Granato M, van Eeden FJ, Schach U, Trowe T, Brand M, Furutani-Seiki M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ , Kane DA et al (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva.. Development, 123, 399-413. RIS download Bibtex download
  • Karlstrom RO, Trowe T, Klostermann S, Baier H, Brand M, Crawford AD, Grunewald B, Haffter P, Hoffmann H, Meyer SU , M眉ller BK et al (1996) Zebrafish mutations affecting retinotectal axon pathfinding.. Development, 123, 427-438. RIS download Bibtex download
  • Schilling TF, Piotrowski T, Grandel H, Brand M, Heisenberg CP, Jiang YJ, Beuchle D, Hammerschmidt M, Kane DA, Mullins MC , van Eeden FJ et al (1996) Jaw and branchial arch mutants in zebrafish I: branchial arches.. Development, 123, 329-344. RIS download Bibtex download
  • Piotrowski T, Schilling TF, Brand M, Jiang YJ, Heisenberg CP, Beuchle D, Grandel H, van Eeden FJ, Furutani-Seiki M, Granato M , Haffter P et al (1996) Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation.. Development, 123, 345-356. RIS download Bibtex download
  • Kelsh RN, Brand M, Jiang YJ, Heisenberg CP, Lin S, Haffter P, Odenthal J, Mullins MC, van Eeden FJ, Furutani-Seiki M , Granato M et al (1996) Zebrafish pigmentation mutations and the processes of neural crest development.. Development, 123, 369-389. RIS download Bibtex download
  • Odenthal J, Rossnagel K, Haffter P, Kelsh RN, Vogelsang E, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Hammerschmidt M , Heisenberg CP et al (1996) Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio.. Development, 123, 391-398. RIS download Bibtex download
  • van Eeden FJ, Granato M, Schach U, Brand M, Furutani-Seiki M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ, Kane DA , Kelsh RN et al (1996) Genetic analysis of fin formation in the zebrafish, Danio rerio.. Development, 123, 255-262. RIS download Bibtex download
  • Chen JN, Haffter P, Odenthal J, Vogelsang E, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Hammerschmidt M, Heisenberg CP , Jiang YJ et al (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish.. Development, 123, 293-302. RIS download Bibtex download
  • Ransom DG, Haffter P, Odenthal J, Brownlie A, Vogelsang E, Kelsh RN, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M , Hammerschmidt M et al (1996) Characterization of zebrafish mutants with defects in embryonic hematopoiesis.. Development, 123, 311-319. RIS download Bibtex download
  • Jiang YJ, Brand M, Heisenberg CP, Beuchle D, Furutani-Seiki M, Kelsh RN, Warga RM, Granato M, Haffter P, Hammerschmidt M , Kane DA et al (1996) Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio.. Development, 123, 205-216. RIS download Bibtex download
  • Furutani-Seiki M, Jiang YJ, Brand M, Heisenberg CP, Houart C, Beuchle D, van Eeden FJ, Granato M, Haffter P, Hammerschmidt M , Kane DA et al (1996) Neural degeneration mutants in the zebrafish, Danio rerio.. Development, 123, 229-239. RIS download Bibtex download
  • Whitfield TT, Granato M, van Eeden FJ, Schach U, Brand M, Furutani-Seiki M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ , Kane DA et al (1996) Mutations affecting development of the zebrafish inner ear and lateral line.. Development, 123, 241-254. RIS download Bibtex download
  • van Eeden FJ, Granato M, Schach U, Brand M, Furutani-Seiki M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ, Kane DA , Kelsh RN et al (1996) Mutations affecting somite formation and patterning in the zebrafish, Danio rerio.. Development, 123, 153-164. RIS download Bibtex download
  • Brand M, Heisenberg CP, Jiang YJ, Beuchle D, Lun K, Furutani-Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane DA , Kelsh RN et al (1996) Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain.. Development, 123, 179-190. RIS download Bibtex download
  • Heisenberg CP, Brand M, Jiang YJ, Warga RM, Beuchle D, van Eeden FJ, Furutani-Seiki M, Granato M, Haffter P, Hammerschmidt M , Kane DA et al (1996) Genes involved in forebrain development in the zebrafish, Danio rerio.. Development, 123, 191-203. RIS download Bibtex download
  • Odenthal J, Haffter P, Vogelsang E, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Hammerschmidt M, Heisenberg CP, Jiang YJ , Kane DA et al (1996) Mutations affecting the formation of the notochord in the zebrafish, Danio rerio.. Development, 123, 103-115. RIS download Bibtex download
  • Brand M, Heisenberg CP, Warga RM, Pelegri F, Karlstrom RO, Beuchle D, Picker A, Jiang YJ, Furutani-Seiki M, van Eeden FJ , Granato M et al (1996) Mutations affecting development of the midline and general body shape during zebrafish embryogenesis.. Development, 123, 129-142. RIS download Bibtex download
  • Hammerschmidt M, Pelegri F, Mullins MC, Kane DA, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Haffter P, Heisenberg CP , Jiang YJ et al (1996) Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio.. Development, 123, 143-151. RIS download Bibtex download
  • Kane DA, Maischein HM, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ , Kelsh RN et al (1996) The zebrafish early arrest mutants.. Development, 123, 57-66. RIS download Bibtex download
  • Mullins MC, Hammerschmidt M, Kane DA, Odenthal J, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Haffter P, Heisenberg CP , Jiang YJ et al (1996) Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes.. Development, 123, 81-93. RIS download Bibtex download
  • Hammerschmidt M, Pelegri F, Mullins MC, Kane DA, van Eeden FJ, Granato M, Brand M, Furutani-Seiki M, Haffter P, Heisenberg CP , Jiang YJ et al (1996) dino and mercedes, two genes regulating dorsal development in the zebrafish embryo.. Development, 123, 95-102. RIS download Bibtex download
  • Haffter P, Granato M, Brand M, Mullins MC, Hammerschmidt M, Kane DA, Odenthal J, van Eeden FJ, Jiang YJ, Heisenberg CP , Kelsh RN et al (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio.. Development, 123, 1-36. RIS download Bibtex download
  • Kane DA, Hammerschmidt M, Mullins MC, Maischein HM, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Haffter P, Heisenberg CP , Jiang YJ et al (1996) The zebrafish epiboly mutants.. Development, 123, 47-55. RIS download Bibtex download
  • Furutani-Seiki M, Jiang Y-J, Brand M, Heisenberg C-P, Houart C, Beuchle D, van Eeden FJM, Granato M, Haffter P, Hammerschmidt M , Kane DA et al (1996) . International Journal of Developmental Neuroscience, 14, 80-80. RIS download Bibtex download
  • Haffter P, Odenthal J, Mullins MC, Lin S, Farrell MJ, Vogelsang E, Haas F, Brand M, Van Eeden FJM, Furutani-Seiki M , Granato M et al (1996) Mutations affecting pigmentation and shape of the adult zebrafish. Roux's Archives of Developmental Biology, 206(4), 260-276. RIS download Bibtex download
  • Schulte-Merker S, van Eeden FJ, Halpern ME, Kimmel CB & N眉sslein-Volhard C (1994) no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene.. Development, 120(4), 1009-1015. RIS download Bibtex download
  • N枚lling J, van Eeden FJ & de Vos WM (1993) . Mol Gen Genet, 240(1), 81-91. RIS download Bibtex download
  • N枚lling J, van Eeden FJ, Eggen RI & de Vos WM (1992) . Nucleic Acids Res, 20(24), 6501-6507. RIS download Bibtex download
  • 艁ysyganicz PK, Pooranachandran N, Liu X, Adamson KI, Zielonka K, Elworthy S, van Eeden FJ, Grierson AJ & Malicki JJ () . Frontiers in Cell and Developmental Biology, 9. RIS download Bibtex download
  • Jiang Z, Evans T, Savage AM, Loose M, Chico TJA, van Eeden FJM & Wilkinson RN () . RIS download Bibtex download
  • Marchi D, Santhakumar K, Markham E, Li N, Storbeck K-H, Krone N, Cunliffe VT & van Eeden FJM () . PLOS Genetics, 16(5). RIS download Bibtex download
  • Novodvorsky P, Watson O, Gray C, Wilkinson RN, Reeve S, Smythe C, Beniston R, Plant K, Maguire R, M. K. Rothman A , Elworthy S et al () . PLoS ONE, 10(10). RIS download Bibtex download

Chapters

  • Allen C, Argenton F, Van Eeden FJ & Tiso N (2022) , Laboratory Fish in Biomedical Research (pp. 139-155). Elsevier RIS download Bibtex download

Conference proceedings papers

  • Elks P, van der Vaart M, van Eeden F, Spaink H, Walmsley S, Meijer A & Renshaw S (2014) Hypoxia signaling modulates neutrophil nitric oxide in a zebrafish tuberculosis model. EUROPEAN RESPIRATORY JOURNAL, Vol. 44 RIS download Bibtex download
  • Chico T, Watson O & van Eeden F (2013) . HEART, Vol. 99 RIS download Bibtex download
  • Thompson AAR, Elks PM, Marriott HM, Higgins KR, Parmar S, Shaw G, Eamsamarng S, McGrath EE, Formenti F, Van Eeden FJ , Kinnula VL et al (2012) . THORAX, Vol. 67 (pp A1-A1) RIS download Bibtex download
  • Judson E, Santhakumar K & van Eeden F (2012) . VASCULAR PHARMACOLOGY, Vol. 56(5-6) (pp 355-356) RIS download Bibtex download
  • Holden BJ, van Eeden FJ, Ong ACM & Chico TJ (2011) . HEART, Vol. 97(20) (pp 12-12) RIS download Bibtex download
  • Watson OJ, van Eeden FJ, Gray C & Chico TJA (2011) . HEART, Vol. 97 (pp A43-A43) RIS download Bibtex download
  • Hammond K, van Eeden F & Whitfield T (2009) . MECHANISMS OF DEVELOPMENT, Vol. 126 (pp S155-S155) RIS download Bibtex download
  • Santhakumar K, van Rooijen E, McKee S, Voest E, Giles R & van Eeden F (2009) . MECHANISMS OF DEVELOPMENT, Vol. 126 (pp S60-S61) RIS download Bibtex download
  • Yelon D, Thomas NA, Koudijs M, Van Eeden F & Joyner AL (2008) . DEVELOPMENTAL BIOLOGY, Vol. 319(2) (pp 603-604) RIS download Bibtex download
  • Knoll R, Postel R, Kratzner R, Hennecke G, Vacaru AM, Vakeel P, Knoll G, Schafer K, Bos E, Den Hertog J , Peters PJ et al (2007) Integrin-linked kinase and laminin alpha 4 mutations cause human cardiomyopathy. CIRCULATION, Vol. 116(16) (pp 221-221) RIS download Bibtex download
  • Van Rooijen E, Van Rooijen C, Voest EE, Giles RH & Van Eeden F (2006) Proper vascular development and heart morphogenesis require tumor suppressor VHL in zebrafish development.. CANCER RESEARCH, Vol. 66(8) RIS download Bibtex download

Preprints

  • Baranasic D, H枚rtenhuber M, Balwierz P, Zehnder T, Mukarram AK, Nepal C, Varnai C, Hadzhiev Y, Jimenez-Gonzalez A, Li N , Wragg J et al (2021) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Derrick CJ, S谩nchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & No毛l ES (2019) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Kim HR, Santhakumar K, Markham E, Baldera D, Bryant HE, El-Khamisy SF & van Eeden FJ (2019) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Marchi D, Santhakumar K, Markham E, Li N, Storbeck K-H, Krone N, Cunliffe VT & van Eeden FJM (2019) , Cold Spring Harbor Laboratory. RIS download Bibtex download
Grants
  • EU FP7
  • EU Trancyst
  • HEFCE
Teaching activities

Undergraduate:

  • BMS109 Lab Skills & Skills Sessions
  • BMS110 Research Topics in Biomedicine
  • BMS242/243 Principles of Developmental Biology
  • BMS243/247 Stem Cells
  • BMS336 Modelling Human Disease and Dysfunction
  • Level 3 Practical and Dissertation Modules

Masters (MSc):

  • BMS6083 Practical Developmental Genetics (Co-ordinator)
Professional activities and memberships
  • Invited teacher at regular EMBO courses at the MPI in T眉bingen (recently also 91直播)
  • Presenter at open science days and public lectures in Utrecht/Wageningen
  • International collaboration on TILLING with Hubrecht Laboratory Utrecht/Sanger Inst. Cambridge
  • Invited speaker at: ZDM8, Boston,  Aug 2015; Zebrafish PI Meeting Ein gedi 2014; BSDB meeting 2013; European zebrafish meeting Barcelona 2013
  • Reviewer for: BBSRC, Development, FNRS, Swiss research council, Singapore, Hong-Kong and many others